Liquid Biopsies in Cancer Diagnosis, Monitoring and Prognosis

Ulivi, Paola; Indraccolo, Stefano

doi:10.3390/biomedicines10112748

Cited by 2 publications

(2 citation statements)

References 8 publications

(8 reference statements)

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“…However, the density gradient centrifugation can maximize the removal of interference caused by proteins. sEV samples prepared by differential ultracentrifugation often have low purity compared to density gradient ultracentrifugation [ 28 ]. Density gradient ultracentrifugation separates particles by layering them on different densities of biocompatible media (such as sucrose).…”

Section: Sev Isolation and Characterizationmentioning

confidence: 99%

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Prostate cancer-derived small extracellular vesicle proteins: the hope in diagnosis, prognosis, and therapeutics

Chen,

Pang,

Zhou

et al. 2023

J Nanobiotechnol

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Current diagnostic tools for prostate cancer (PCa) diagnosis and risk stratification are insufficient. The hidden onset and poor efficacy of traditional therapies against metastatic PCa make this disease a heavy burden in global men’s health. Prostate cancer-derived extracellular vesicles (PCDEVs) have garnered attention in recent years due to their important role in communications in tumor microenvironment. Recent advancements have demonstrated PCDEVs proteins play an important role in PCa invasion, progression, metastasis, therapeutic resistance, and immune escape. In this review, we briefly discuss the applications of sEV proteins in PCa diagnosis and prognosis in liquid biopsy, focus on the roles of the PCa-derived small EVs (sEVs) proteins in tumor microenvironment associated with cancer progression, and explore the therapeutic potential of sEV proteins applied for future metastatic PCa therapy. Graphical Abstract

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Section: Sev Isolation and Characterizationmentioning

confidence: 99%

“…This results in a high level of purity and selectivity. However, the high cost, low yield, and the need for additional elution steps limit their application [ 28 ]. The reliability of immunoaffinity technology has been substantiated in a PCa study.…”

Section: Sev Isolation and Characterizationmentioning

confidence: 99%