Cancer de la vulve : stades diagnostiques, traitement et survie dans un pays aux ressources limitées (Burkina Faso)

Zongo, Nayi; Somé, N. Korsaga; Ouédraogo, Smaïla; Ouedraogo, Aimé Sosthène; Zamané, Hyacinthe; Zida, Maurice; Ouangré, Edgar; Sanou, A; Niampa, Pascal; Lompo, Olga Mélanie; Traoré, Adama; Dem, Ahmadou

doi:10.1016/j.bulcan.2019.07.008

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…A Z-plasty was performed in 42 cases, being 58.3% of the patients (Figs. 1,2,3,4). The indication was a wide resection with an impossibility of direct suture.…”

Section: Resultsmentioning

confidence: 99%

“…They include basal cell carcinomas, squamous cell carcinomas, melanomas and cutaneous sarcomas [3][4][5]. Surgery plays an important role in the management of skin cancers [3,6,7]. The modalities of surgical treatment depend on the location, histological type, size of the lesion and the patient's condition [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…One in three new cancers in Switzerland is a skin cancer [2]. They include basal cell carcinomas, squamous cell carcinomas, melanomas and cutaneous sarcomas [3][4][5]. Surgery plays an important role in the management of skin cancers [3,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…In the West, the diagnosis of skin tumours is made at an early stage, with small lesions allowing resection and suturing in majority of cases [8][9][10]. The situation is quite different in developing countries, particularly in Burkina Faso [3,7]. Indeed, the long delays in consultation lead to a delay in diagnosis and management [7].…”

Section: Introductionmentioning

confidence: 99%

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Skin Oncoplasties: Is Z-Plasty A Technique of Choice In Situation of Limited Resources? Case of Burkina Faso.

Zongo

Ouédraogo

Mamadou³

et al. 2021

Preprint

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Background: In developing countries, the long delays in consultation lead to a delay in diagnosis and management of the skin tumours. The lesions are often large and brings the problem of skin coverage after their resections. Several reconstruction techniques allow skin coverage. The objective of this study is to describe the place of Z-plasty in the surgical treatment of skin cancers in Ouagadougou.Patients and methods: It was a two-centre, retrospective, descriptive study on Z-plasty in skin cancers. It included patients who underwent surgery between January 1st, 2013 and March 30th, 2021 in Ouagadougou. Scar quality and healing time in Z-plasty were compared with those of secondary healing. Results: In 8 years and 3 months, 171 skin cancers were identified. The mean time to consultation was 13.6 months. The average size of the tumours was 9 cm. A Z-plasty was performed in 42 cases, being 58.3% of the patients operated on. The average healing time was 15 days. It was four and a half times shorter in Z-plasty than in secondary healing. Ischaemic necrosis of the Z-corner was noted in 7 cases. The recurrence rate in Z-plasty and secondary healing was 7.1% and 9.1% respectively. Hypertrophic or keloidal scars were noticed in 7 cases and hypochromia in 2 cases.Conclusion: Z-plasty is a technique of choice for skin coverage after large resections in surgical oncology. It reduces the healing time and the cost of postoperative care without increasing the risk of tumour recurrence.

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“…A Z-plasty was performed in 42 cases, being 58.3% of the patients (Figs. 1,2,3,4). The indication was a wide resection with an impossibility of direct suture.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Skin Oncoplasties: Is Z-Plasty A Technique of Choice In Situation of Limited Resources? Case of Burkina Faso.

Zongo

Ouédraogo

Mamadou³

et al. 2021

Preprint

Self Cite

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Skin oncoplasties: O-to-Z technique a technique of choice in situation of limited resources? Case of Burkina Faso

Zongo

Ouédraogo²,

Windsouri³

et al. 2022

World J Surg Onc

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Background In developing countries, the long delays in consultation lead to a delay in diagnosis and management of the skin tumors. The lesions are often large and bring the problem of skin coverage after their resections. Several reconstruction techniques allow skin coverage. The objective of this study is to describe the place of O-to-Z technique in the surgical treatment of skin cancers in Ouagadougou. We hypothesized that O-to-Z technique reduces healing times and the number of dressings compared with directed wound healing. Patients and methods It was a two-center, retrospective, descriptive study on O-to-Z technique in skin cancers. It included patients who underwent surgery between January 1st, 2013 and March 30th, 2021 in Ouagadougou. Scar quality and healing time in Z-plasty were compared with those of secondary healing. We used the Student’s t test. Results In 8 years and 3 months, 171 skin cancers were identified. The mean time to consultation was 13.6 months. The average size of the tumors was 9 cm. An O-to-Z technique was performed in 42 cases, being 58.3% of the patients operated on. The average healing time was 15 days. It was four and a half times shorter in O-to-Z technique than in secondary healing. Ischemic necrosis of the Z-corner was noted in 7 cases. The recurrence rate in O-to-Z technique and secondary healing was 7.1% and 9.1% respectively. Hypertrophic or keloidal scars were noticed in 7 cases and hypochromia in 2 cases. Conclusion O-to-Z technique is a technique of choice for skin coverage after large resections in surgical oncology. It reduces the healing time and the cost of postoperative care without increasing the risk of tumor recurrence.

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Evaluation of PD-L1 expression in vulvar cancer

Sahraoui

Manai²,

Yaïche³

et al. 2022

F1000Res

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Background: The PD-1/PD-L1 inhibitory immune checkpoint seems to have a significant prognostic impact in the evolution of certain cancers such as bronchopulmonary cancer, breast cancer, lymphomas etc. Indeed, it has been suggested that PD-L1 expression was associated with a worse prognosis due to its immunosuppressive activity within tumor tissue. Currently, the evaluation of the expression of these biomarkers is of increasing interest in gynecological cancers. Hence, we proposed to study the expression of PDL1 in vulvar cancer. Our aims were to study the expression profile of PD-L1 in vulvar cancer by immunohistochemistry and to correlate its expression with overall and relapse-free survival rates. Methods: This is a retrospective study conducted at the pathological anatomy and cytology department of the Saleh Azaiez Institute, Tunis, Tunisia involving 55 patients followed for vulvar cancer over a period of 13 years from 2008 to 2021. Clinicopathologic data was collected from medical records and pathology reports. Results: PD-L1 expression in vulvar squamous cell carcinoma was observed in 44% of cases. This expression was noted in 33% of cases in tumor cells and in 11% of cases in lymphocytes. The median follow-up period was 40 months. During this period, 30% of patients relapsed. For all recurrence cases, 77% were during the first two years. The overall survival rate was 68.4% at two years and 50.3% at five years. The recurrence-free survival rate was 63.8% at five years. Overall survival as well as recurrence-free survival were more reduced in the case of PD-L1 expression. However, this difference was not significant (p=0.07). Conclusions: These results, although insufficient, emphasize the prognostic value that PDL1 could play in vulvar cancer as described in the literature. Despite the low numbers and the unavailability of data for some cases, our results encourage carrying out this work on larger populations.

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Cancer de la vulve : stades diagnostiques, traitement et survie dans un pays aux ressources limitées (Burkina Faso)

Cited by 3 publications

References 15 publications

Skin Oncoplasties: Is Z-Plasty A Technique of Choice In Situation of Limited Resources? Case of Burkina Faso.

Skin Oncoplasties: Is Z-Plasty A Technique of Choice In Situation of Limited Resources? Case of Burkina Faso.

Skin oncoplasties: O-to-Z technique a technique of choice in situation of limited resources? Case of Burkina Faso

Evaluation of PD-L1 expression in vulvar cancer

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