Cancer de l’endomètre : place de la chimiothérapie adjuvante

Lheureux, S; Joly, Florence

doi:10.1684/bdc.2011.1518

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…Endometrial cancer, the most common gynaecological cancer in developed nations, has an incidence second only to that of cervical cancer [1,2]. The number of cases in Taiwan is increasing steadily [3].…”

Section: Introductionmentioning

confidence: 99%

“…The number of cases in Taiwan is increasing steadily [3]. Obesity, diabetes mellitus, endogenous hormones, chronic hyperinsulinemia, late menopause, unopposed estrogen exposure, tamoxifen, the oral contraceptive pill, the reproductive factors parity, and age at birth are considered the primary risk factors [2,4,5,6]. The worldwide increase in obesity and decrease in fertility suggest that the incidence of endometrial cancer will continue to rise, such that endometrial cancer will become a serious public health problem in the future [7].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Proliferative Effects of Siegesbeckia orientalis Ethanol Extract on Human Endometrial RL-95 Cancer Cells

et al. 2014

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Endometrial cancer is a common malignancy of the female genital tract. This study demonstrates that Siegesbeckia orientalis ethanol extract (SOE) significantly inhibited the proliferation of RL95-2 human endometrial cancer cells. Treating RL95-2 cells with SOE caused cell arrest in the G2/M phase and induced apoptosis of RL95-2 cells by up-regulating Bad, Bak and Bax protein expression and down-regulation of Bcl-2 and Bcl-xL protein expression. Treatment with SOE increased protein expression of caspase-3, -8 and -9 dose-dependently, indicating that apoptosis was through the intrinsic and extrinsic apoptotic pathways. Moreover, SOE was also effective against A549 (lung cancer), Hep G2 (hepatoma), FaDu (pharynx squamous cancer), MDA-MB-231 (breast cancer), and especially on LNCaP (prostate cancer) cell lines. In total, 10 constituents of SOE were identified by Gas chromatography-mass analysis. Caryophyllene oxide and caryophyllene OPEN ACCESSMolecules 2014, 19 19981 are largely responsible for most cytotoxic activity of SOE against RL95-2 cells. Overall, this study suggests that SOE is a promising anticancer agent for treating endometrial cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Proliferative Effects of Siegesbeckia orientalis Ethanol Extract on Human Endometrial RL-95 Cancer Cells

et al. 2014

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“…According to Sobel et al [4], for stage I, chemotherapy was rarely used, either pre-or post-operatively, in our study. According to Lheureux et al [15], adjuvant chemotherapy can give promising results after surgery. After a mean follow-up of 15 months, 84.5% of operated patients were alive.…”

Section: Discussionmentioning

confidence: 99%

Endometrial Cancer: Epidemiological, Histological and Therapeutic Aspects in the Gynecology-Obstetrics Department of the Donka National Hospital, CHU of Conakry

Diallo,

Balde,

Sylla

et al. 2023

OJOG

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Objective: To study the epidemiological, histological and therapeutic characteristics of endometrial cancer in the Gynecology-Obstetrics department of the Donka National Hospital, CHU of Conakry. Methods: We conducted a retrospective descriptive study of 86 patients with endometrial cancer treated in the Gynecology-Obstetrics department of the Donka National Hospital from January 1, 2011, to December 31, 2021, based on their medical records. We analysed the epidemiological, histological and therapeutic aspects of the disease. Results: Endometrial cancer accounted for 3.1% of the 2793 gynecological pathology cases registered in the department during the study period, ranking third. The mean age of the patients was 63 ± 5 years. Most of them were uneducated (59.3%), postmenopausal (91.9%), nulliparous (30.2%), obese (65.1%) and hypertensive (77.1%). More than half of the patients (53.4%) were diagnosed at stage I. Endometrioid adenocarcinoma was the predominant histological type (68.6%). Surgery was performed in 96.6% of the patients, and chemotherapy in 14.0%. After a mean follow-up of 15 months, 84.5% of the patients were alive. Conclusion: Endometrial cancer is a common gynecological malignancy in our department. Endometrioid adenocarcinoma is the most frequent histological subtype. Surgery is the main treatment modality.

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“…En dehors des stades I à faible risque de récidive (IA de type I et de grade histologique 1 et 2) qui ne nécessitent pas de traitement adjuvant, la radiothérapie post-opératoire est le traitement standard. Elle réduit de façon significative le risque de rechute locorégionale, elle n'améliore cependant pas la survie globale [10,11]. Quoique la radio-chimiothérapie semble faire, de plus en plus, ses preuves en situation néoadjuvante pour les cancers localement avancés [12].…”

Section: Discussionunclassified

“…Les taux de survie à 5 ans varient en fonction du stade de la maladie. Ils varient de 80% pour les stades I à 10% pour les stades IV [10,14]. Les faibles taux de survie sont liés dans nos conditions aux stades avancés et à la difficulté d'accès à la radiothérapie et à la chimiothérapie [15].…”

Section: Discussionunclassified

Traitement des cancers de l’endomètre à l’institut Joliot Curie de Dakar : à propos de 30 cas

Thiam¹,

Kahatwa²,

Ka³

et al. 2021

Af J Oncol

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AIM: To study the therapeutic aspects of endometrial cancer at the Joliot Curie Institute in Dakar. MATERIALS AND METHODS: This is a retrospective study conducted at the Joliot Curie Institute in Dakar including all cases of endometrial cancer confirmed by histology between January 2012 and December 2016. RESULTS: There were 30 cases of endometrial cancer over a period of five years. Endometrioid adenocarcinoma was the most common type of histology and was found in 25 patients, or 84% of cases. The patients were classified as stages I and II of FIGO in 43% of cases, stage III in 24% of cases and stage IV in 33% of cases. Colpo-hysterectomy with pelvic lymphadenectomy (CHL) was the main surgical procedure performed. External radiotherapy was performed in three patients or 10%. A case of radiation cystitis and radiodermatitis were recorded as a radiotherapy complication. No patient received brachytherapy. Chemotherapy was performed in 17 patients, ie 56.6%. She was adjuvant in 10 patients, or 34% of cases. Pelvic recurrences were noted in three patients who underwent 10% surgery. After 13 months of follow-up, survival was 50%. CONCLUSION: The most effective treatment modality for endometrial cancer at the Joliot Curie Institute was surgery followed by chemotherapy and Radiation therapy.

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Cancer de l’endomètre : place de la chimiothérapie adjuvante

Cited by 5 publications

References 12 publications

Anti-Proliferative Effects of Siegesbeckia orientalis Ethanol Extract on Human Endometrial RL-95 Cancer Cells

Anti-Proliferative Effects of Siegesbeckia orientalis Ethanol Extract on Human Endometrial RL-95 Cancer Cells

Endometrial Cancer: Epidemiological, Histological and Therapeutic Aspects in the Gynecology-Obstetrics Department of the Donka National Hospital, CHU of Conakry

Traitement des cancers de l’endomètre à l’institut Joliot Curie de Dakar : à propos de 30 cas

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