Cancer Cytosensing Approaches in Miniaturized Settings Based on Advanced Nanomaterials and Biosensors

Purohit, Buddhadev; Kumar, Ashutosh; Mahato, Kuldeep; Roy, Sharmili; Chandra, Pranjal

doi:10.1016/b978-0-12-818823-1.00009-0

Cited by 30 publications

(8 citation statements)

References 99 publications

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“…Other required characteristics are accuracy, selectivity, and sensitivity. To elevate the sensitivity of electrochemical wearable sensors, nanomaterials [64, 65] have been integrated and modified with biorecognition elements such as antibodies [66], DNA, aptamers [67], and enzymes [68]. Capture antibody immobilization on a suitably fabricated surface has been accomplished using a variety of approaches based on target molecules and working electrode materials [69].…”

Section: Sensing Mechanismmentioning

confidence: 99%

Engineering Design, Implementation, and Sensing Mechanisms of Wearable Bioelectronic Sensors in Clinical Settings

et al. 2022

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Wearable sensing devices have transformed the hourly analysis of events such as body signals and environmental risks into real‐time monitoring in minutes or seconds. Wearable sensors have facilitated the ability to obtain useful data by monitoring the physiological parameters and activities of an aided and a healthy individual. Wearable devices employ detectable biomarkers in the human body, such as in tears, saliva, interstitial fluid, sweat, and so on. These can deliver relevant information on human health, online activity monitoring, and therapeutic treatments. This section outlines the significance of sample types and associated biomarkers as indicators in the development and manufacturing of wearable biosensors. We have emphasized the most recent advances of wearables based on skin‐like and textile, giving attention to personalized health monitoring to record signals of motion and physiological and body fluid investigation. Furthermore, this review categorizes wearable biosensors based on the sensing mechanism, electrochemical, optical, and mechanical. Additionally, the recent wearables related to the detection of the newly havoc‐causing pandemic, COVID‐19, and the future perspective for the development of much more advanced and potent wearable biosensors have been highlighted. The final section highlights unmet difficulties and gaps in wearable sensors in personalized therapy.

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Section: Sensing Mechanismmentioning

confidence: 99%

Engineering Design, Implementation, and Sensing Mechanisms of Wearable Bioelectronic Sensors in Clinical Settings

et al. 2022

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“…Therefore, nanotechnology and nanobiosenors can play a major role in producing scalable and inexpensive detection methods (Roy, Malode et al, Purohit, Kumar et al 2019 , Mahapatra, Baranwal et al 2020 , Shetti, Malode et al 2020 ). Nano-biosensors can be used as a challenging point of care diagnostic tools even before symptoms have been shown in patients with very low viral loads (Abdul et al 2020 ).…”

Section: Diagnosis and Treatment Of Sars-cov-2mentioning

confidence: 99%

COVID-19 transmission, vulnerability, persistence and nanotherapy: a review

et al. 2021

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End 2019, the zoonotic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), named COVID-19 for coronavirus disease 2019, is the third adaptation of a contagious virus following the severe acute respiratory syndrome coronavirus in 2002, SARS-CoV, and the Middle East respiratory syndrome virus in 2012, MERS-CoV. COVID-19 is highly infectious and virulent compared to previous outbreaks. We review sources, contagious routes, preventive measures, pandemic, outbreak, epidemiology of SARS-CoV, MERS-CoV and SARS-CoV-2 from 2002 to 2020 using a Medline search. We discuss the chronology of the three coronaviruses, the vulnerability of healthcare workers, coronaviruses on surface and in wastewater, diagnostics and cures, and measures to prevent spreading.

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“…Nowadays, cytosensing is also extensively used for the detection of multiple types of cancer cells [ 106 , 107 ]. There are various surface biomarkers such as MUC-1 (Mucin 1), carcino embryonic antigen (CEA), BRCA1, BRCA2, HERS, folic acid receptors, sialic-acid associated glycoprotein, and many other protein/glycoprotein biomarkers [ 108 ] that are recognized by aptamers [ 109 ], antibodies, and nano-enzymes immobilized on cellulose matrix [ 110 ]. More emphasis has been given on whole cell-system-based biosensing and a microfluidic system for targeting different antigens expressed by cancer cells at the onset of the disease.…”

Section: Biosensors For Detection Of Cellsmentioning

confidence: 99%

Nanobioengineered Sensing Technologies Based on Cellulose Matrices for Detection of Small Molecules, Macromolecules, and Cells

et al. 2021

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Recent advancement has been accomplished in the field of biosensors through the modification of cellulose as a nano-engineered matrix material. To date, various techniques have been reported to develop cellulose-based matrices for fabricating different types of biosensors. Trends of involving cellulosic materials in paper-based multiplexing devices and microfluidic analytical technologies have increased because of their disposable, portable, biodegradable properties and cost-effectiveness. Cellulose also has potential in the development of cytosensors because of its various unique properties including biocompatibility. Such cellulose-based sensing devices are also being commercialized for various biomedical diagnostics in recent years and have also been considered as a method of choice in clinical laboratories and personalized diagnosis. In this paper, we have discussed the engineering aspects of cellulose-based sensors that have been reported where such matrices have been used to develop various analytical modules for the detection of small molecules, metal ions, macromolecules, and cells present in a diverse range of samples. Additionally, the developed cellulose-based biosensors and related analytical devices have been comprehensively described in tables with details of the sensing molecule, readout system, sensor configuration, response time, real sample, and their analytical performances.

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Cancer Cytosensing Approaches in Miniaturized Settings Based on Advanced Nanomaterials and Biosensors

Cited by 30 publications

References 99 publications

Engineering Design, Implementation, and Sensing Mechanisms of Wearable Bioelectronic Sensors in Clinical Settings

Engineering Design, Implementation, and Sensing Mechanisms of Wearable Bioelectronic Sensors in Clinical Settings

COVID-19 transmission, vulnerability, persistence and nanotherapy: a review

Nanobioengineered Sensing Technologies Based on Cellulose Matrices for Detection of Small Molecules, Macromolecules, and Cells

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