Cancer Clinical Trials and Subject Use of Natural Herbal Products

Natural Products Modulate the Multifactorial Multidrug Resistance of Cancer

“…For many of these patients, the use of natural compounds is an essential part of the complementary approach. For example, two studies in the United States have reported that roughly 40% -60% of cancer patients who use some combination of complementary medicine including herbs, vitamins, and/or antioxidants [103] [104]. Most of these patients are using natural compounds without the guidance of their oncologist, or any real guidance from scientific studies.…”

Prostate-Specific Natural Health Products (Dietary Supplements) Radiosensitize Normal Prostate Cells

“…Patients' perception has been that nutritional supplements prevent disease progression, reduce normal tissues toxicities, and/or boost immune system function (11,(19)(20)(21)(22). Reports have attributed high rates of supplement use by cancer patients to the perceived limitations of conventional therapies, abundant media advertising, and a desire for more holistic or natural therapies (23).…”

Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer

“…In the past decades, multiple studies demonstrated that natural herbal products could be promising novel chemotherapeutics for the treatment of human cancers. Various herbal products were found to exhibit anticancer activity by suppressing cell proliferation and metastasis and inducing cell apoptosis and autophagy (23)(24)(25). Previous studies reported that polyphyllin could suppress the progression of multiple human cancers, including lung (26), gastric (27), breast (28) and prostate (29) cancer.…”