Cancer chemotherapy reduces plasma total polyphenols and total antioxidants capacity in colorectal cancer patients

Santiago-Arteche, R.; Muñiz, Pilar; Cavia-Sáiz, Mónica; García-Girón, Carlos; Garcı́a-González, Maria Asunción; Llorente-Ayala, Beatriz; Corral, María Jesús

doi:10.1007/s11033-012-1760-3

Cited by 23 publications

(15 citation statements)

References 25 publications

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“…Radiotherapy and chemotherapy can inhibit or kill cancer, which results in the production of a large number of free radicals, reduced antioxidant activity, increased oxidative stress, interferences with data measurement, and experimental errors. Santiago-Arteche et al[25] also confirmed that total antioxidant capacity (TAC) was significantly lower in patients with CRC who received chemotherapy than in patients who did not receive chemotherapy. Therefore, in the present study we excluded the effects of radiotherapy and chemotherapy.…”

Section: Discussionmentioning

confidence: 95%

Significance of Serum Total Oxidant/Antioxidant Status in Patients with Colorectal Cancer

Feng

Yang

et al. 2017

PLoS ONE

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Oxidative stress is involved in a variety of diseases. Prospective studies investigating the relationship between oxidative stress biomarkers and the status and development of colorectal cancer (CRC) are scarce; previous studies have failed to establish a relationship between the serum total oxidant/antioxidant status and CRC. Therefore, we compared the total serum oxidant/antioxidant levels of CRC patients and healthy subjects, and analyzed their clinical significance in the CRC. Fasting blood samples from 132 CRC patients and 64 healthy subjects were collected. Oxidative stress parameters, including total oxidant status (TOS) and total antioxidant status (TAS), were measured, and the oxidative stress index (OSI) was calculated. The TOS and OSI levels increased significantly (P<0.001) and the TAS level significantly decreased (P<0.001) in the CRC group compared to those in the healthy control group. Oxidative stress parameters differed significantly depending on the patient’s smoking and drinking status (P<0.05). The preoperative and postoperative levels of TOS, TAS, and OSI did not differ significantly between primary sites (colon/rectum) and clinical stages (P>0.05).However, the levels of TOS, TAS, and OSI were significantly different between patients with no metastasis and those with metastases to two organs (P<0.05) Finally, the parameters are affected by smoking and drinking, and subsequent research should be conducted excluding the relevant influencing factors.

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Section: Discussionmentioning

confidence: 95%

Significance of Serum Total Oxidant/Antioxidant Status in Patients with Colorectal Cancer

Feng

Yang

et al. 2017

PLoS ONE

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“…Plasma samples were also subjected to the determination of total polyphenols, using the Folin-Ciocalteu method [26], after extraction according to Serafini et al [33], of free polyphenols with the Folin-Ciocalteu method and after protein precipitation according to the method described by Santiago-Arteche et al [34], of conjugated polyphenols by difference between the previous two classes.…”

Section: Methodsmentioning

confidence: 99%

Improvement of Oxidative Status, Milk and Cheese Production, and Food Sustainability Indexes by Addition of Durum Wheat Bran to Dairy Cows’ Diet

Bonanno

Grigoli

Todaro

et al. 2019

Animals

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Simple SummaryIn the near future, the expected increase in world population will enhance feed versus food competition between animals and humans to face the increasing demand by humans. For this reason, it is of paramount importance to feed ruminants with sources alternative to those representing themselves foods for humans. Durum wheat bran (DWB), similar to other by-products of the agri-food industry, can meet this need, its fiber content is high and represents also a remarkable source of phenolic acids, especially ferulic acid. This compound exerts antioxidant properties improving the health status of animals, and allows the production of functional foods more and more requested by consumers. Accordingly, this experiment demonstrated the suitability of using DWB for dairy cows feeding, because it led to clear advantages in terms of oxidative status of animals, quality of dairy products, and feeding costs. Furthermore, DWB improved the human-edible feed conversion efficiency reducing the use of human-edible feed.AbstractDurum wheat bran (DWB) is a by-product mostly used in feeding ruminants, contributing to decrease in the utilization of feeds suitable as foods for human consumption, thus improving the sustainability of livestock production. However, the potential benefits of DWB, due to its content in phenolic acids, mainly consisting of ferulic acid with antioxidant properties, have not been well clarified yet. Accordingly, in this experiment, 36 lactating cows divided into three groups received, over a period of 100 days, one of three concentrates including DWB at 0% (DWB0), 10% (DWB10), or 20% (DWB20). The concentrates were formulated to be isoproteic and isoenergetic and, to balance the higher fiber content of the concentrates with DWB, the hay in the diets was slightly reduced. During the trial, the group feed intake and the individual milk production were monitored, and cheese was made with bulk milk from each group. Milk yield and microbiological characteristics of milk and cheese were similar among groups, indicating no DWB effect on cows performance and fermentation process. Milk from DWB20 group resulted slightly higher in casein and curd firmness (a2r). In cows fed DWB, the higher polyphenol intake was responsible for higher blood contents of these bioactive compounds, that seemed to have contributed in reducing the level of reactive oxygen metabolites (ROMs), which were higher in DWB0 cows. DWB20 cheeses showed a higher polyphenol content, lower number of peroxides, and higher antioxidant capacity than DWB0 cheeses. DWB20 and DWB10 diets resulted less expensive. In addition, the DWB20 group showed the best indexes heFCE (human edible feed conversion efficiency = milk/human edible feed) and NFP (net food production = milk − human edible food), expressed as crude protein or gross energy. In conclusion, the DWB fed to dairy cows at 12% of diet dry matter (DM) can lead to benefits, such as the improvement of oxidative status of cows, milk quality, shelf-life, and functional properties of cheese, and mig...

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“…In light of the evidence obtained in preclinical models, a clinical trial evaluation is mandatory for translation into humans and to further validate the feasibility and efficacy of such natural product formulations for their use in a clinical setting. Of note, a de-creased total antioxidant capacity associated with a progressive reduction in polyphenol plasma levels has been described in stage II–IV CRC patients, with significantly lower values in subjects undergoing therapy with cytostatic drugs, alone or in combination with monoclonal antibodies [ 104 ].…”

Section: Dietary Polyphenols As Adjuvants In Colorectal Cancer Therapymentioning

confidence: 99%

Dietary Polyphenols: Promising Adjuvants for Colorectal Cancer Therapies

Bracci

Fabbri

Cornò

et al. 2021

Cancers

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Colorectal cancer (CRC) is a major cancer type and a leading cause of death worldwide. Despite advances in therapeutic management, the current medical treatments are not sufficient to control metastatic disease. Treatment-related adverse effects and drug resistance strongly contribute to therapy failure and tumor recurrence. Combination therapy, involving cytotoxic treatments and non-toxic natural compounds, is arousing great interest as a promising more effective and safer alternative. Polyphenols, a heterogeneous group of bioactive dietary compounds mainly found in fruit and vegetables, have received great attention for their capacity to modulate various molecular pathways active in cancer cells and to affect host anticancer response. This review provides a summary of the most recent (i.e., since 2016) preclinical and clinical studies using polyphenols as adjuvants for CRC therapies. These studies highlight the beneficial effects of dietary polyphenols in combination with cytotoxic drugs or irradiation on both therapy outcome and drug resistance. Despite substantial preclinical evidence, data from a few pilot clinical trials are available to date with promising but still inconclusive results. Larger randomized controlled studies and polyphenol formulations with improved bioavailability are needed to translate the research progress into clinical applications and definitively prove the added value of these molecules in CRC management.

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Cancer chemotherapy reduces plasma total polyphenols and total antioxidants capacity in colorectal cancer patients

Cited by 23 publications

References 25 publications

Significance of Serum Total Oxidant/Antioxidant Status in Patients with Colorectal Cancer

Significance of Serum Total Oxidant/Antioxidant Status in Patients with Colorectal Cancer

Improvement of Oxidative Status, Milk and Cheese Production, and Food Sustainability Indexes by Addition of Durum Wheat Bran to Dairy Cows’ Diet

Dietary Polyphenols: Promising Adjuvants for Colorectal Cancer Therapies

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