Significance of Serum Total Oxidant/Antioxidant Status in Patients with Colorectal Cancer

Abstract

Oxidative stress is involved in a variety of diseases. Prospective studies investigating the relationship between oxidative stress biomarkers and the status and development of colorectal cancer (CRC) are scarce; previous studies have failed to establish a relationship between the serum total oxidant/antioxidant status and CRC. Therefore, we compared the total serum oxidant/antioxidant levels of CRC patients and healthy subjects, and analyzed their clinical significance in the CRC. Fasting blood samples from 132 CRC patients and 64 healthy subjects were collected. Oxidative stress parameters, including total oxidant status (TOS) and total antioxidant status (TAS), were measured, and the oxidative stress index (OSI) was calculated. The TOS and OSI levels increased significantly (P<0.001) and the TAS level significantly decreased (P<0.001) in the CRC group compared to those in the healthy control group. Oxidative stress parameters differed significantly depending on the patient’s smoking and drinking status (P<0.05). The preoperative and postoperative levels of TOS, TAS, and OSI did not differ significantly between primary sites (colon/rectum) and clinical stages (P>0.05).However, the levels of TOS, TAS, and OSI were significantly different between patients with no metastasis and those with metastases to two organs (P<0.05) Finally, the parameters are affected by smoking and drinking, and subsequent research should be conducted excluding the relevant influencing factors.

Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research

“…Similar results have been reported by Wu et al concerning plasma TOS and TAS levels. These authors did not observe any statistically significant differences between TOS and TAS levels and primary tumor location in the colon and rectum (p > 0.05), but they did not include the division into right-and left-sided colons [15].…”

“…Its blood serum level is a measure of lipid peroxidation. Total oxidant status (TOS) and total antioxidant status (TAS) are parameters used to measure the general oxidative and antioxidant status of the body, respectively [15].…”

Foeniculum vulgare (Fennel) promotes functional recovery and ameliorates oxidative stress following a lesion to the sciatic nerve in mouse model

“…It is considered as one of the reasons for neural damage after PNI. Total oxidant status (TOS) is used to estimate the oxidative status of a living system (Wu et al, ). It is expressed in µmol H 2 O 2 equiv/L.…”

Peer Review #3 of "Association of CYBA gene (-930 A/G and 242 C/T) polymorphisms with oxidative stress in breast cancer: a case-control study (v0.1)"

“…Oxidative stress induces uncontrolled lipid peroxidation that produces aldehyde end-products, such as free fatty acids, malondialdehyde (MDA) might cause cell injury and death. In addition, cancer initiation and progression have also been shown to be associated with oxidative stress by causing DNA mutations or inducing DNA damage, genome instability, and cell proliferation (Srivastava et al, 2009;Visconti & Grieco, 2009;Wang et al, 2011;Wu et al, 2017).…”