Cancer cell specific targeting of nanogels from acetylated hyaluronic acid with low molecular weight

Park, Wooram; Kim, Kyoung Sub; Bae, Byoung-chan; Kim, Young-Heui; Na, Kun

doi:10.1016/j.ejps.2010.04.008

Cited by 65 publications

(33 citation statements)

References 32 publications

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“…They confirmed that an increase in the DS of acetyl groups produced a reduction of the critical aggregation concentration values and the size of the nanogels due to the increase in hydrophobicity, which in turn increased the drug--loading efficiency and capacity, and prolonged the half--maximal DOX release time [82]. Similar tendencies were observed for other systems described below [84,90].…”

Section: Drug--loaded Self--assembled Systems Based On Hasupporting

confidence: 65%

“…In fact, increased levels of HA in tissues and body fluids have been observed in many cancers [258], suggesting its use as prognostic marker of various types of tumors [259,260]. This accumulation has been related to the overexpression of HA--binding receptors such as the cluster determinant 44 (CD44), which is implicated in the regulation of tumor growth and metastasis [261], the receptor for HA--mediated motility (RAHMM) or the lymphatic vessel endothelial receptor--1 (LYVE--1) in cancer cells [82]. Indeed, Choi et al [262] [188].…”

Section: 6--self--assemblies Based On Poly(2--oxazolines) (Pox)mentioning

confidence: 99%

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Self-assembling polymer systems for advanced treatment of cancer and inflammation

Palao-Suay

Gómez‐Mascaraque

Aguilar

et al. 2016

Progress in Polymer Science

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Section: Drug--loaded Self--assembled Systems Based On Hasupporting

confidence: 65%

Section: 6--self--assemblies Based On Poly(2--oxazolines) (Pox)mentioning

confidence: 99%

Self-assembling polymer systems for advanced treatment of cancer and inflammation

Palao-Suay

Gómez‐Mascaraque

Aguilar

et al. 2016

Progress in Polymer Science

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“…7b). These results suggest that the His-HA nanoparticles prepared in this study selectively bind to CD44 and internalize into the cancer cells via receptormediated endocytosis [4,22,33].…”

Section: In Vitro Cellular Uptake Of Hh-npsmentioning

confidence: 87%

“…Figure 6 shows the fluorescent microscopic images of cells incubated with FITC-labeled nanoparticles or DOX-loaded nanoparticles. HA can bind to CD44 receptor, which is overexpressed in various kinds of cancer cells such as MCF-7 cells lines [21,22]. To confirm receptor-mediated endocytosis of HHNPs, the competition study was carried out.…”

Section: In Vitro Cellular Uptake Of Hh-npsmentioning

confidence: 99%

“…Thus HA, as a targeting moiety, is potent in pharmaceutical applications for anti-cancer therapeutics. In the recent studies, HA conjugates encapsulating anticancer agents such as paclitaxel [19][20][21], doxorubicin [22], and siRNA [23], have exhibited enhanced targeting ability to the tumor and higher therapeutic efficacy compared with free anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of nanoparticles based on histidine–hyaluronic acid conjugates as doxorubicin carriers

Liu

Wang

et al. 2012

J Mater Sci: Mater Med

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Histidine-hyaluronic acid (His-HA) conjugates were synthesized using hyaluronic acid (HA) as a hydrophilic segment and histidine (His) as hydrophobic segment by 1-ethyl-3(3-dimethylaminopropyl)carbodiimide (EDC) mediated coupling reactions. The structural characteristics of the His-HA conjugates were investigated using (1)H NMR. His-HA nanoparticles (HH-NPs) were prepared based on His-HA conjugates, and the characteristics of HH-NPs were investigated using dynamic light scattering, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and fluorescence spectroscopy. The particles were between 342 and 732 nm in size, depending on the degree of substitution (DS) of the His. TEM and SEM images indicated that the morphology of HH-NPs was spherical in shape. The critical aggregation concentrations of HH-NPs ranged from 0.034 to 0.125 mg/ml, which decreased with an increase in the DS of the His. Images of fluorescence microscopy indicate that HH-NPs were taken up by the cancer cell line (MCF-7), and significantly decreased by competition inhibition of free HA. From the cytotoxicity test, it was found that DOX-loaded HH-NPs exhibited similar dose and time-dependent cytotoxicity against MCF-7 cells with free DOX.

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Vitamin B_c-Bearing Hydrophilic Photosensitizer Conjugate for Photodynamic Cancer Theranostics

Kim

Park

et al. 2015

Macromol. Biosci.

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The accurate diagnosis and proper therapy for cancer are essential to improve the success rate of cancer treatment. Here, we demonstrated that the vitamin Bc -bearing hydrophilic photosensitizer conjugate folic acid-polyethylene glycol-pheophorbideA (FA-PEG-PheoA) has been synthesized for the intracellular diagnosis and photodynamic therapy of a tumor. The synthesized vitamin Bc -bearing hydrophilic photosensitizer conjugate has been characterized for the folic acid receptor expressing the ability to target tumor cells, which is facilitated by the chemical conjugation with folic acid. The vitamin Bc -bearing hydrophilic photosensitizer conjugate internalization mechanism was identified through a competitive inhibition test with free folic acid. We optimized the laser-sensitive, cytotoxicity changeable, vitamin Bc -bearing hydrophilic photosensitizer conjugate concentration, which is non-cytotoxic under normal conditions and specifically cytotoxic toward cancer cells (maximum 69.15%) under laser irradiation conditions used for theranostic agents. The cancer therapeutic and diagnosis effects of synthesized conjugate were confirmed in MDA-MB-231 cells and MDA-MB-231-bearing mice. As a result, the vitamin Bc -bearing hydrophilic photosensitizer conjugate exhibited a highly photodynamic therapeutic effect, which enabled the selective detection of a folic acid receptor expressing cancer using optical imaging.

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Cancer cell specific targeting of nanogels from acetylated hyaluronic acid with low molecular weight

Cited by 65 publications

References 32 publications

Self-assembling polymer systems for advanced treatment of cancer and inflammation

Self-assembling polymer systems for advanced treatment of cancer and inflammation

Preparation and characterization of nanoparticles based on histidine–hyaluronic acid conjugates as doxorubicin carriers

Vitamin B_c-Bearing Hydrophilic Photosensitizer Conjugate for Photodynamic Cancer Theranostics

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Cancer cell specific targeting of nanogels from acetylated hyaluronic acid with low molecular weight

Cited by 65 publications

References 32 publications

Self-assembling polymer systems for advanced treatment of cancer and inflammation

Self-assembling polymer systems for advanced treatment of cancer and inflammation

Preparation and characterization of nanoparticles based on histidine–hyaluronic acid conjugates as doxorubicin carriers

Vitamin Bc-Bearing Hydrophilic Photosensitizer Conjugate for Photodynamic Cancer Theranostics

Contact Info

Product

Resources

About

Vitamin B_c-Bearing Hydrophilic Photosensitizer Conjugate for Photodynamic Cancer Theranostics