Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling

Kluz, Paige; Kolb, Ryan; Xie, Qing; Borcherding, Nicholas; Liu, Qi; Luo, Yuewan; Kim, Myungchul; Wang, Linna; Zhang, Yinan; Li, Wei; Stipp, Christopher S.; Gibson‐Corley, Katherine N.; Zhao, Chen; Qi, Hank H.; Bellizzi, Andrew M.; Tao, Andy; Sugg, Sonia L.; Weigel, Ronald J.; Zhou, Daohong; Shen, Xian; Zhang, Weizhou

doi:10.1038/s41388-020-1203-x

Cited by 12 publications

(7 citation statements)

References 60 publications

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“…Beyond neutrophils, the presence of CD177 on epithelial cells, in cervical cancer, prostate cancer and ovarian cancer has been documented. Analysis of CD177 in mammary epithelial cells revealed a strong CD177 expression on epithelial cells that was significantly reduced in paired cancer specimens [73]. These data suggest CD177 molecule as a cancer cell-intrinsic tumor suppressor and introduced this molecule as a potential good prognostic factor in different cancer types [73].…”

Section: Nb Antigenmentioning

confidence: 87%

“…Analysis of CD177 in mammary epithelial cells revealed a strong CD177 expression on epithelial cells that was significantly reduced in paired cancer specimens [73]. These data suggest CD177 molecule as a cancer cell-intrinsic tumor suppressor and introduced this molecule as a potential good prognostic factor in different cancer types [73]. A recent study documented TRALI induction in a CD177 pre-immunized recipient after transfusion with packed red blood cells (PRBC) from CD177 positive donors, but not CD177 negative donors.…”

Section: Nb Antigenmentioning

confidence: 99%

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Neutrophil-Specific Antigens: Immunobiology, Genetics and Roles in Clinical Disorders

Lalezari¹,

Bayat²

2022

Blood Groups - More Than Inheritance of Antigenic Substances

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Neutrophils are the most abundant nucleated cells in blood circulation and play important roles in the innate and adaptive immune responses. Neutrophil-specific antigens, only expressed on neutrophils, are glycoproteins originally identified in studies on neonatal neutropenia due to fetal-maternal incompatibility and autoimmune neutropenia of infancy. The most investigated neutrophil–specific antigens are the NA and NB antigens that their incompatibilities also cause transfusion-induced febrile reactions and acute lung injury, a potentially fatal reaction, and in bone marrow transplantation, causing graft rejection. NA antigens are members of the immunoglobulin superfamily and are low-affinity Fc-receptors FcγRIIIb (CD16b). Fc receptors connect the F(ab), the antigen-binding fragment of the antibody molecules, to neutrophils and lead them to recognize and phagocytize the targeted antigens. The NB (CD177) antigen belongs to the urokinase-type Plasminogen Activator Receptor Superfamily (uPAR, CD59, Ly6), but its specific functions have not been fully determined. It is known, however, that NB antigen binds proteinase-3 (PR3 to the neutrophil membrane), a serine protease. In clinical studies, it was also demonstrated that NB expression is highly elevated in Polycythemia Vera and is unexpectedly expressed in some cancer tissues. Neutrophil-specific antigens are examples of antigens that have important biological and clinical activities beyond antigenicity.

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Section: Nb Antigenmentioning

confidence: 87%

Section: Nb Antigenmentioning

confidence: 99%

Neutrophil-Specific Antigens: Immunobiology, Genetics and Roles in Clinical Disorders

Lalezari¹,

Bayat²

2022

Blood Groups - More Than Inheritance of Antigenic Substances

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“…In a recent publication, the high CD177 levels discriminated against non‐survivors patients with COVID‐19 [32]. Also, in ovarian cancer, CD177 expression on tumour tissue is related to tumour malignancy and a bad prognosis [33], while in breast and cervical cancers, it is related to shorter overall survival [34, 35].…”

Section: Discussionmentioning

confidence: 99%

Dysregulated neutrophil extracellular traps formation in sepsis

Mulet,

Osuna‐Gómez,

Zamora

et al. 2023

Immunology

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The migration and antimicrobial functions of neutrophils seem to be impaired during sepsis and contribute to the dysregulation of immune responses and disease pathogenesis. However, the role of neutrophil extracellular traps (NETs) remains to be clarified. The study aimed to analyse sequential phenotypic and functional changes of neutrophils during the time following the diagnosis of sepsis. We prospectively enrolled 49 septic and 18 non‐septic patients from the intensive care unit (ICU) and emergency room (ER) and 20 healthy volunteers (HV). Baseline blood samples from septic and non‐septic patients were collected within 12 h of admission to the hospital. Additional septic samples were drawn at 24, 48 and 72 h after baseline. Neutrophil phenotype and degranulation capacity were assessed by flow cytometry and NET formation was quantified by fluorescence. Neutrophils from septic patients exhibited increased CD66b, CD11b and CD177 expression but displayed reduced NET formation at baseline compared with non‐septic patients and HV controls. Neutrophils expressing CD177 interacted less with platelets, were related to reduced NETosis and tended to indicate a worse sepsis outcome. In vitro experiments revealed that neutrophil function is compromised by the origin of sepsis, including the pathogen type and the affected organ. Assessing a decision tree model, our study showed that CD11b expression and NETosis values are useful variables to discriminate septic from non‐septic patients. We conclude that sepsis induces changes in neutrophil phenotype and function that may compromise the effective capacity of the host to eliminate pathogens.

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“…Therefore, the specific mechanism of action of MMP3 and MMP1 in colorectal cancer needs to be further studied. CD177 is a glycosylphosphatidylinositol-linked cell surface protein that is heterogeneously expressed by neutrophils, and its expression is associated with good prognosis in breast, prostate, cervical, and lung cancers (47). Studies have shown that CD177 + neutrophils inhibit epithelial tumorigenesis and serve as independent predictors of prognosis in patients with CRC (48).…”

Section: Discussionmentioning

confidence: 99%

A novel prognostic model based on urea cycle-related gene signature for colorectal cancer

et al. 2022

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BackgroundColorectal cancer (CRC) is the second leading cause of cancer-related deaths in the world. This study aimed to develop a urea cycle (UC)-related gene signature that provides a theoretical foundation for the prognosis and treatment of patients with CRC.MethodsDifferentially expressed UC-related genes in CRC were confirmed using differential analysis and Venn diagrams. Univariate Cox and least absolute shrinkage and selection operator regression analyses were performed to identify UC-related prognostic genes. A UC-related signature was created and confirmed using distinct datasets. Independent prognostic predictors were authenticated using Cox analysis. The Cell-type Identification by Estimating Relative Subsets of RNA Transcripts algorithm and Spearman method were applied to probe the linkage between UC-related prognostic genes and tumor immune-infiltrating cells. The Human Protein Atlas database was used to determine the protein expression levels of prognostic genes in CRC and normal tissues. Verification of the expression levels of UC-related prognostic genes in clinical tissue samples was performed using real-time quantitative polymerase chain reaction (qPCR).ResultsA total of 49 DEUCRGs in CRC were mined. Eight prognostic genes (TIMP1, FABP4, MMP3, MMP1, CD177, CA2, S100P, and SPP1) were identified to construct a UC-related gene signature. The signature was then affirmed using an external validation set. The risk score was demonstrated to be a credible independent prognostic predictor using Cox regression analysis. Functional enrichment analysis revealed that focal adhesion, ECM-receptor interaction, IL-17 signaling pathway, and nitrogen metabolism were associated with the UC-related gene signature. Immune infiltration and correlation analyses revealed a significant correlation between UC-related prognostic genes and differential immune cells between the two risk subgroups. Finally, the qPCR results of clinical samples further confirmed the results of the public database.ConclusionTaken together, this study authenticated UC-related prognostic genes and developed a gene signature for the prognosis of CRC, which will be of great significance in the identification of prognostic molecular biomarkers, clinical prognosis prediction, and development of treatment strategies for patients with CRC.

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Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling

Cited by 12 publications

References 60 publications

Neutrophil-Specific Antigens: Immunobiology, Genetics and Roles in Clinical Disorders

Neutrophil-Specific Antigens: Immunobiology, Genetics and Roles in Clinical Disorders

Dysregulated neutrophil extracellular traps formation in sepsis

A novel prognostic model based on urea cycle-related gene signature for colorectal cancer

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