Cancer bronchique primitif et risques professionnels dans une population Nord-Africaine

Ketfi, A.; Zanoun, N.; Laouedj, I.; Gharnaout, M.; Fraga, S.

doi:10.11604/pamj.2020.37.120.21755

Cited by 5 publications

(5 citation statements)

References 26 publications

(13 reference statements)

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“…Our ndings indicate that the male smoking rate was over 79.1%. This rate is close to the previous Algerian study conducted by Kefti et al [11], while other studies in the Maghreb region have reported higher rates varying between 90% and 94%. Concerning female smoking, all females in our study were non-smokers, similar ndings were obtained in studies conducted in our region with rates of 0-4% [8, 10,[13][14][15].…”

Section: Discussionsupporting

confidence: 91%

“…We found that lung cancer mainly affects patients older than 50 years at the moment of diagnosis, with a median age of 61 years, which is similar to that reported in other Algerian studies [8][9][10][11]. These ndings are also close to those found in studies carried out in Maghreb countries [12-15, 17, 19].…”

Section: Discussionsupporting

confidence: 90%

“…Regarding lung cancer incidence by histological subtypes, our ndings indicate that ADC was the most common subtype, followed by SQCC. Recent studies from the region of Maghreb have reported a similar proportion of ADC compared with SQCC [10,11,[13][14][15]. Although comparable to previous studies in our region, the SQCC subtype predominantly occurred [8,12].…”

Section: Discussionsupporting

confidence: 87%

“…The low incidence of lung cancer in women in the region of North Africa largely re ects differences in tobacco consumption which represents about 2-5.6% among women versus 27-55% among men [18]. Besides, women have less access to professions with high occupational exposure to pulmonary carcinogens [11].…”

Section: Discussionmentioning

confidence: 99%

“…Other risk factors such as occupational exposure, air pollution, respiratory diseases, diet, and genetic susceptibility, may be responsible for the development of lung cancer [6]. According to the study by Kefti et al approximately 50% of Algerian patients with lung cancer had occupational exposure to a carcinogen in their workplace, such as diesel exhaust gases, silica, PAHs, welding fumes, and asbestos [11]. In our study, exposure to occupational carcinogens was observed at a low rate, mostly related to the welding, tobacco industry, and fuel/gas.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological and clinicopathological features of lung cancer in Algeria

Lahmadi

Beddar

Ketit

et al. 2022

Preprint

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Purpose: Lung cancer is the most commonly diagnosed cancer in men and the leading cause of cancer-related death in Algeria. We investigated the clinicopathological characteristics of a group of patients with lung cancer in Eastern Algeria, that might reflect a national landscape. Methods: This retrospective study was performed on 173 histologically proven cases of lung cancer at Benbadis university hospital of Constantine from January 2015 to February 2021. Clinical and pathological variables were investigated based on the available data found in the patient's medical records. Results: Lung cancer showed a male predominance with a sex ratio of 6.5. Majority of our patients (86%) aged greater than 50 years with a median age of 61 years. Histologically, adenocarcinoma was found in over 56.6% of the cases, followed by squamous cell carcinoma with 22.5%, whereas 12.8% were non-NSCLC subtypes. Tobacco smoking was estimated at 79.1% in men. Non-smokers represented over 32.5% of patients, of which 45.1% were female. Most of our patients (79%) have an advanced stage at diagnosis, including 57.3% with metastatic disease. Around 60% of patients underwent chemotherapy, of which 81% was first-line treatment, with a median diagnostic delay of almost 4 months. Conclusion: Lung cancer presents at an early age and advanced stage in Algerian patients. Smoking remains the most important risk factor in men and adenocarcinoma is the predominant histological subtype. Thus, primary prevention, based on tobacco control and screening programs, and access to novel therapies may be the best strategies to reduce lung cancer morbidity and mortality.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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