Cancer associates with risk and severe events of <scp>COVID</scp>‐19: A systematic review and meta‐analysis

Tian, Yuan; Qiu, Xiaowei; Wang, Cheng-Xiang; Zhao, Jianxin; Jiang, Xin; Niu, Wenquan; Huang, Jinchang; Zhang, Fengyu

doi:10.1002/ijc.33213

Cited by 111 publications

(108 citation statements)

References 60 publications

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“…Older adults; people with underlying diseases, including diabetes and cardiovascular disease; and patients with cancer are at a high risk of COVID-19. These patients are likely to develop severe symptoms and have a high mortality rate (Liang et al, 2020;Xie et al, 2020;Tian et al, 2021). Therefore, there is an increasing concern among health care professionals regarding the effect of immunosuppressive therapy on patients with IBD who receive corticosteroids, thiopurines, or biological agents.…”

Section: Use Of Thiopurines In Ibd Patients During the Coronavirus Disease 2019 (Covid-19) Pandemicmentioning

confidence: 99%

Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases

et al. 2021

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Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) of unknown etiology, characterized by repeated relapse and remission. The efficacy of thiopurine in IBD was first reported in the late 1960s. Thiopurines are used to alleviate the symptoms of IBD, especially UC. These drugs have a steroid-sparing potential and are widely used for the purpose of maintaining long-term remission in steroid-dependent cases. Therefore, thiopurines tend to be used long-term, but adverse events that accompany long-term use, such as lymphoproliferative disorders, must be monitored with care. In contrast, thiopurine plays a critical role in controlling the immunogenicity of biologics. Furthermore, although thiopurine is an old drug, new findings, including the prediction of serious adverse events such as severe alopecia and acute advanced leukopenia, by nudix hydrolase 15 gene polymorphism analysis, as well as the possibility of appropriate drug monitoring by detailed analysis of 6-thioguanine nucleotides have been clarified. However, the consequences of thiopurine withdrawal have not been determined and further studies, including randomized controlled trials, are necessary to answer the clinical question regarding the scenarios in which thiopurine withdrawal is possible.

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Section: Use Of Thiopurines In Ibd Patients During the Coronavirus Disease 2019 (Covid-19) Pandemicmentioning

confidence: 99%

Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases

et al. 2021

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Section: Introductionmentioning

confidence: 99%

“…9,10 This evidences provide the rationale for the high susceptibility of cancer patients to SARS-CoV-2. 11,12 However, not all cancer patients are similarly at risk for COVID-19. 13,14 SARS-CoV-2 is transmitted mainly through the respiratory or digestive route: 3 the lungs are in direct contact with the external environment, although the expression of ACE2 in lung tissues was generally lower than that in the digestive tract, pulmonary epithelial cells are the main targets of SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers

He¹,

Hua²,

Sun³

et al. 2021

JIR

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Background Cancer patients are more vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than the general population, with lung epithelial cells or enterocytes being the main targets. However, the expressions of SARS-CoV-2 entry-related genes in aerodigestive cancers have not been fully elucidated. Methods In this study, the expressions of SARS-CoV-2 receptors and cofactors, including angiotensin I-converting enzyme 2 (ACE2), basigin (BSG) and transmembrane serine protease 2 (TMPRSS2), were comprehensively assessed. We compared BSG and TMPRSS2 expressions between aerodigestive cancers and matched normal tissues through Gene Expression Profiling Interactive Analysis 2 (GEPIA2). Furthermore, expressions in healthy colon tissues at different anatomical locations were explored using the Genotype-Tissue Expression (GTEx) dataset. In addition, expressions among different tumor stages and the prognostic values were detected through GEPIA2. Moreover, the correlation between gene expression and immune infiltration was explored via Tumor Immune Estimation Resource (TIMER). Finally, expressions in primary colorectal cancer (CRC), lung metastasis and liver metastasis were investigated using the Gene Expression Omnibus (GEO) dataset GSE41258. Results Similar to ACE2, TMPRSS2 and BSG were also highly expressed in the digestive tracts. Intriguingly, BSG/TMPRSS2 expression in adjacent normal colon tissue or lung tissue was higher than that in corresponding healthy tissue, whereas they varied not among different tumor stages and correlated not with prognosis in aerodigestive cancers. Moreover, ACE2 was expressed at higher levels in lung metastases from CRC than in normal lung tissues. Conclusion SARS-CoV-2 entry genes were highly expressed in CRC, and we reported for the first time higher expression of ACE2 in lung metastases from CRC than in normal lung, indicating that these patients may be more susceptible to extrapulmonary or pulmonary SARS-CoV-2 infection. Since our study is a bioinformatic analysis, further experimental evidences and clinical data are urgently needed.

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“…cancer is a prime example of such progress. 5 diagnosis, disease stage, treatment, gender, age and co-morbidities. [7][8][9][10] Older age and co-morbidities, which are established risk factors for severe events and death from COVID-19, are more common in patients with cancer.…”

Section: Tian Et Al's Systematic Review Of Patients With Covid-19 Andmentioning

confidence: 99%

COVID‐19 and the risk to cancer patients in China

Williams

Stebbing

2020

Intl Journal of Cancer

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Cancer associates with risk and severe events of COVID‐19: A systematic review and meta‐analysis

Cited by 111 publications

References 60 publications

Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases

Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases

Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers

COVID‐19 and the risk to cancer patients in China

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