Canavalia gladiata and Arctium lappa extracts ameliorate dextran sulphate sodium-induced inflammatory bowel disease by enhancing immune responses

Ji, Kon-Young; Jang, Ji-Hye; Lee, Eun-Hee; Kim, Su-Man; Song, Hyeong-Woo; Yang, Won‐Kyung; Kim, Han-Young; Kim, Kun-Hoae; Lee, Young-Sil; Kim, Dong-Seon; Kang, Hyung‐Sik; Kim, Seung-Hyung

doi:10.1016/j.jff.2018.03.018

Cited by 11 publications

(5 citation statements)

References 32 publications

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“…The antioxidant and the anti-inflammatory activity of A. lappa leaves, fruits, and roots, as well as individual compounds isolated from them, has been confirmed in studies in cell-free systems, on specific cell lines and using animal models [ 22 , 23 , 24 , 25 ]. It has been shown that the extract from greater burdock roots significantly reduced the time of regeneration of damaged skin [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 95%

Arctium lappa and Arctium tomentosum, Sources of Arctii radix: Comparison of Anti-Lipoxygenase and Antioxidant Activity as well as the Chemical Composition of Extracts from Aerial Parts and from Roots

Skowrońska

Granica

Dziedzic

et al. 2021

Plants

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Arctium lappa is a weed used in traditional medicine in the treatment of skin inflammation and digestive tract diseases. Arctium tomentosum is used in folk medicine interchangeably with Arctium lappa and, according to European Medicines Agency (EMA) monography, provides an equal source of Arctii radix (Bardanae radix), despite the small amount of research confirming its activity and chemical composition. The aim of the study was the comparison of the anti-lipoxygenase and the antioxidant activity, scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion (O2•−), and hydrogen peroxide (H2O2), of 70 % (v/v) ethanolic extracts from the aerial parts and the roots of Arctium lappa and Arctium tomentosum. In the tested extracts, the total polyphenols content and the chemical composition, analyzed with the HPLC–DAD–MSn method, were also compared. The extracts were characterized by strong antioxidant properties, but their ability to inhibit lipoxygenase activity was rather weak. A correlation between the content of polyphenolic compounds and antioxidant activity was observed. The extracts from A. lappa plant materials scavenged reactive oxygen species more strongly than the extracts from A. tomentosum plant materials. Moreover, the extracts from A. lappa plant materials were characterized by the statistically significantly higher content of polyphenolic compounds.

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Section: Introductionmentioning

confidence: 95%

Arctium lappa and Arctium tomentosum, Sources of Arctii radix: Comparison of Anti-Lipoxygenase and Antioxidant Activity as well as the Chemical Composition of Extracts from Aerial Parts and from Roots

Skowrońska

Granica

Dziedzic

et al. 2021

Plants

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“…Immunomodulatory effects by activating NK cells 12 . Mixture of Canavalia gladiata and Arctium lappa extract exhibit immunity enhancing effects by certain ways viz., increasing immune cells, inhibiting inflammatory cytokines, secreating immune activating cytokines, stimulating NK cell activity, suppressing stress related harmones and strengthening brain memory 52,53,54 .…”

Section: Anti-inflammatory and Immunological Activitesmentioning

confidence: 99%

The Pharmacological and Therapeutic Activities of Canavalia gladiata (Jacq.) DC.

Pal

Pandey

Dhawal

et al. 2022

J. Drug Delivery Ther.

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Canavalia gladiata is a perennial ethnomedicinal climber food plant found throughout the World. It shows many therapeutic properties which can be utilized for the treatment against many human diseases. In this review, we surveyed the recent findings on the pharmacological and therapeutic properties of Canavalia gladiata. The objective of this is to provide detail analysis on active compounds present in this species and to provide information regarding its pharmacological activities on human diseases and safety. Its bioactive compounds possess outstanding pharmacological properties like hemagglutianting activity, HIV-I inhibition, antimicrobial, antiproliferative, hepatoprotective, ROS- inhibitor, anti-cancer and anti-diabetic properties has been studied. The chemical constituents, pharmacological activities and therapeutic studies of C. gladiata showed a promising medicinal plant with various chemical compounds and numerous pharmacological activities. Keywords: Pharmacological activities, Therapeutics, Bioactive compounds, Canavalia gladiata.

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“…Further, cells were washed and resuspended in the ACK Lysis Buffer (Thermo Fisher Scientific, Waltham, MA, USA) for 5 min and then immediately washed twice in HBSS. Freshly isolated murine cells (5 × 10 5 cells) were resuspended in 100 µL of the FACS Stain Buffer (BD Biosciences, San Jose, CA, USA) per assay tube [29]. Isolated cells were washed twice with the FACS buffer and then immunofluorescence staining was performed at 4 • C. After reacting with primary antibodies for 30 min, cells were washed with PBS three or more times and then measured with FACSCalibur ® (BD Bioscience, San Jose, MA, USA).…”

Section: Immune Cell Phenotype Analysismentioning

confidence: 99%

Enhancement of Immune Activities of Mixtures with Sasa quelpaertensis Nakai and Ficus erecta var. sieboldii

Kwon

Choi

Han

et al. 2020

Foods

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The objective of the present study was to develop a concoction of natural products that could dramatically improve immune function with minimal possible side effects. Sasa quelpaertensis Nakai and Ficus erecta var. sieboldii are plants that are native to Jeju Island, Korea and are known to be rich in physiologically active substances. We prepared a mixture of different proportions and extraction conditions using two natural plants and determined their optimum mixing ratio and extraction method by assessing immune function-related biomarkers in RAW264.7 macrophages. Optimal extract (HR02/04(8:2)-W) was selected from in vitro experiments and its immunity-enhancing efficacy was evaluated in mice. After oral administration of extract to BALB/c mice for 2 weeks, nitric oxide production in the peritoneal exudate cells, natural killer cell cytotoxicity, cytokine expression in splenocytes, and total cell number of immune tissues and phenotype analysis were evaluated. Our results demonstrated that HR02/04(8:2)-W significantly enhanced the immune system by increasing natural killer cell activity, cytokine expression, and total number of cells in immune tissues. In conclusion, our study validates the role of HR02/04(8:2)-W in enhancing immunity and its potential development as a functional food.

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Canavalia gladiata and Arctium lappa extracts ameliorate dextran sulphate sodium-induced inflammatory bowel disease by enhancing immune responses

Cited by 11 publications

References 32 publications

Arctium lappa and Arctium tomentosum, Sources of Arctii radix: Comparison of Anti-Lipoxygenase and Antioxidant Activity as well as the Chemical Composition of Extracts from Aerial Parts and from Roots

Arctium lappa and Arctium tomentosum, Sources of Arctii radix: Comparison of Anti-Lipoxygenase and Antioxidant Activity as well as the Chemical Composition of Extracts from Aerial Parts and from Roots

The Pharmacological and Therapeutic Activities of Canavalia gladiata (Jacq.) DC.

Enhancement of Immune Activities of Mixtures with Sasa quelpaertensis Nakai and Ficus erecta var. sieboldii

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