Canalicular adenoma of the parotid gland

Philpott, Carl; Kendall, C H; Murty, G. E.

doi:10.1258/0022215053222824

Cited by 19 publications

(19 citation statements)

References 12 publications

(22 reference statements)

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“…In general, is seems that CanAd may not develop in major salivary glands. Cases reported thus far in the major salivary glands (parotid, submandibular) are either not well illustrated or lack immunohistochemistry studies to confirm the diagnosis [25,64,69,[92][93][94][95]. Additional investigation is encouraged.…”

Section: Clinical Informationmentioning

confidence: 99%

Canalicular Adenoma: A Clinicopathologic and Immunohistochemical Analysis of 67 Cases with a Review of the Literature

Thompson

Bauer

Chiosea

et al. 2014

Head and Neck Pathol

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There is a lack of a comprehensive immunohistochemical (IHC) analysis of canalicular adenoma (CanAd), especially when combined with a description of the unique histologic features. Given the usual small biopsies, IHC may be useful in distinguishing CanAd from other tumors in the differential diagnosis. Retrospective. The patients included 54 females and 13 males (4.2:1), aged 43-90 years, with a mean age at presentation of 69.9 years. Clinical presentation was generally a mass (n = 61) slowly increasing in size (mean 38.5 months), affecting the upper lip (n = 46), buccal mucosa (n = 17) or palate (n = 4), involving the right (n = 29), left (n = 24) or midline (n = 9), without any major salivary gland tumors. The tumors ranged in size from 0.2 to 3 cm (mean 1.2 cm). Most tumors were multilobular or bosselated (76 %), often surrounded by a capsule. Histologically, the tumors were characterized by cystic spaces, tumor cords with beading, tubule formation, and by the presence of luminal squamous balls (n = 41). The cells were cuboidal to columnar with stippled chromatin. Mitoses were inconspicuous. A myxoid stroma (n = 64), sclerosis (n = 42), luminal hemorrhage (n = 51), and luminal microliths (calcifications) (n = 33) were characteristic. Nine (13.4 %) were multifocal. CanAd showed the following characteristic immunohistochemistry findings: CK-pan and S100 protein (strong, diffuse reaction); peripheral or luminal GFAP reaction; CK5/6 and p16 luminal squamous ball reaction; SOX10 nuclear reaction; cytoplasmic p63 reaction. CanAd are unique minor salivary gland tumors showing a distinct architecture and phenotype. They predilect to older women, with the majority multilobulated and affecting the upper lip, multifocal in 13 %; no major salivary gland tumors were identified. S100 protein, CK-pan, GFAP and SOX10 are positive, with luminal squamous balls highlighted by CK5/6 or p16.

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Section: Clinical Informationmentioning

confidence: 99%

Canalicular Adenoma: A Clinicopathologic and Immunohistochemical Analysis of 67 Cases with a Review of the Literature

Thompson

Bauer

Chiosea

et al. 2014

Head and Neck Pathol

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“…Se localiza en la cavidad oral con predilección por el labio superior (70 % a 90 % de los casos) y rara vez en otros sitios, como el paladar y la parótida (1,3,(5)(6)(7)(8)(9). Suele presentarse en adultos mayores de 50 años con máxima incidencia en la séptima década.…”

Section: Discussionunclassified

“…En la histopatología, se observan cordones de doble fila de células columnares o cúbicas con patrón alternante descrito como "collar de perlas" (beading): los cordones se disponen paralelamente en contacto estrecho y posteriormente se separan formando estructuras similares a ductos que dan origen al término "canalicular" de este tumor (1,3,4,(5)(6)(7)(8)(9)(11)(12)(13)(14). Estas estructuras similares a ductos, pueden dilatarse y llegar a conformar quistes con formaciones papilares (1,5,11).…”

Section: Hallazgos Morfológicosunclassified

Adenoma canalicular multifocal del labio superior: reporte de un caso y revisión de la literatura

Abaúnza-Chagín

Turbay-Juvinao²,

Carreño

et al. 2017

iatreia

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Recibido: marzo 9 de 2016 Aceptado: abril 13 de 2016Cómo citar: Abaúnza-Chagín MC, Turbay-Juvinao N, Vargas-Carreño EJ, Amador CE. Adenoma canalicular multifocal del labio superior: reporte de un caso y revisión de la literatura. Iatreia. 2017 Abr-Jun;30(2):187-193. DOI 10.17533/udea.iatreia.v30n2a07. RESUMENEl adenoma canalicular (AC) es una neoplasia epitelial benigna infrecuente de las glándulas salivales menores localizada principalmente en el labio superior. Se manifiesta como un nó-dulo menor de 3 centímetros, indoloro, no ulcerado y de crecimiento lento. El diagnóstico diferencial se debe hacer con otros tumores de las glándulas salivales como adenoma de células basales, adenoma pleomórfico y carcinoma adenoide quístico.Se presenta el caso de una paciente con antecedente de adenoma canalicular en el labio superior extirpado 13 años antes, que consultó en junio de 2015 por una lesión de 8 mm de diá-metro en la misma localización. En septiembre del mismo año se resecó la lesión, incluyendo la glándula salival accesoria adyacente. El estudio histopatológico confirmó nuevamente el diagnóstico de AC y mostró multifocalidad del tumor en la glándula salival accesoria.

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“…Even less is known about its multicentric tendency and its characteristic localization to the upper lip. Some authors have suggested that the multifocal nature of this tumor is related to "field cancerization" caused by an unknown, [7,8] whereas others have suggested the multifocal dysplasia of developmental origin. [9] There is increasing evidence that canalicular adenoma is derived from ductal luminal cells.…”

Section: Discussionmentioning

confidence: 99%

Canalicular adenoma of the parotid gland: A case report

Puttaswamy¹,

Subramanya²,

Raju³

et al. 2014

JCRI

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Canalicular adenomas are uncommon benign salivary gland tumors commonly affecting the minor salivary glands. Usually, 90-95% of these are reported to occur in the upper lip, followed by the buccal mucosa and palate. Here, we report a case that involved the major salivary gland as a solitary discrete mass in the lower pole of the parotid gland. The mass was surgically excised and which histopathologically revealed normal parotid tissue along an extremely cellular area enveloped by a fibrous connective tissue capsule. Cellular areas showed cells with hyperchromatic nuclei, basally placed nucleus arranged in the form of interlacing cords, small islands, all separated by thin delicate connective septa all these features characteristic of canalicular adenoma.

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Canalicular adenoma of the parotid gland

Cited by 19 publications

References 12 publications

Canalicular Adenoma: A Clinicopathologic and Immunohistochemical Analysis of 67 Cases with a Review of the Literature

Canalicular Adenoma: A Clinicopathologic and Immunohistochemical Analysis of 67 Cases with a Review of the Literature

Adenoma canalicular multifocal del labio superior: reporte de un caso y revisión de la literatura

Canalicular adenoma of the parotid gland: A case report

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