Can you ever collect too many oocytes?

Abstract

No funding was required. There is no conflict of interest, except that G.K., V.M. and C.M. are shareholders in Monash IVF Pty Ltd.

How many oocytes are optimal to achieve multiple live births with one stimulation cycle? The one-and-done approach

“…Of note, groups 4 and 5 had the highest likelihood of having a blastocyst trans-ferred in the index (fresh) cycle (73 % and 87% respectively). Consistent with previous studies (35,36) we found that high oocyte yield results in increased numbers of usable blastocysts.…”

AMH as a Prognostic Factor for Blastocyst Development

“…The risk of OHSS, which is a potentially life-threatening complication of ovarian stimulation, also increases with (Steward et al, 2014). Most studies put the optimal number of retrieved oocytes between 10 and 15 (Briggs et al, 2015;van der Gaast et al, 2006;Sunkara et al, 2011). Even in the currently discussed study, the increase was less pronounced over 15 oocytes.…”

Luteal-phase ovarian stimulation increases the number of mature oocytes in older women with severe diminished ovarian reserve

“…The mounting knowledge of human ovarian follicular waves (Baerwald et al 2003(Baerwald et al , 2012 provided new treatment options for human ovarian stimulation and oocyte retrieval that could improve IVF outcome in women with DOR. Theoretically, the possibility of having a higher number of oocytes retrieved during a single menstrual cycle by fully exploiting the various follicular waves could offer higher chances to find a reproductively competent embryo, thus improving the live birth rate per attempt (Briggs et al 2015). This approach could be particularly useful in older women with severe DOR (Zhang 2015).…”