Can We RISE to the Challenge of Youth-Onset Type 2 Diabetes?

Buse, John B.; D’Alessio, David A.; Riddle, Matthew C.

doi:10.2337/dci18-0025

Cited by 10 publications

(8 citation statements)

References 15 publications

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“…They may develop severe insulin resistance followed by the same comorbidities seen in adults with obesity: specifically prediabetes and diabetes. For youth who develop T2DM there is at least a 50% chance that the disease will progress despite treatment [15][16][17]. Other comorbidities often exacerbate the disease of obesity: hypertension, nonalcoholic fatty liver disease, obstructive sleep apnea, premature puberty, irregular menstruation and polycystic ovary syndrome (PCOS) and orthopedic conditions such as SCFE and Blount's disease [11].…”

Section: Pediatric Obesity Algorithm and Multidiscplinary Approach To...mentioning

confidence: 99%

Progress in pediatric obesity: new and advanced therapies

Cuda¹,

Censani

2022

Current Opinion in Pediatrics

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Purpose of reviewIn this review, we discuss new medical and surgical options for the treatment of children and adolescents with obesity. We review the impact of COVID-19 on this vulnerable population. We also discuss the recent availability of screening tests for rare genetic causes of obesity.Recent findingsCOVID-19 increased the prevalence of obesity among children and adolescents. This population is at increased risk for severe disease. The field of pediatric obesity has benefited from the approval of two new antiobesity medications: liraglutide and setmelanotide. We discuss indications for their use. New guidelines for surgical options for the treatment of children and adolescents with obesity are reviewed. These options are increasingly used as part of the comprehensive care for these children.SummaryThe epidemic of childhood obesity continues. COVID-19 and the associated isolation contributed to the problem. However, promising new medical and surgical therapies and screening tests for rare genetic causes of obesity are available. These new diagnostic and therapeutic options bring renewed enthusiasm to the treatment of children and adolescents with obesity and increased recognition that obesity is a chronic disease starting in childhood deserving intervention to prevent consequences.

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Section: Pediatric Obesity Algorithm and Multidiscplinary Approach To...mentioning

confidence: 99%

Progress in pediatric obesity: new and advanced therapies

Cuda¹,

Censani

2022

Current Opinion in Pediatrics

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“…Adolescents with type 2 diabetes or obesity have risks for the development of future cardiometabolic disease. Both the Treatment Options for Type 2 Diabetes in Adolescents and Youth study (TODAY Study Group, 2012) and the Restoring Insulin Secretion (RISE) study (Buse, D'Alessio, & Riddle, 2018) revealed a more aggressive and worsening trajectory of disease onset and progression in adolescents compared to adults. While more is needed to understand the differences in βcell function in youth, early lifestyle intervention remains a priority for pediatric nurses and health professionals to address barriers that are unique for each adolescent and their family, considering cultural preferences and strategies for engaging exercise into daily life to avert future cardiovascular disease.…”

Section: Conclusion and Practice Implicationsmentioning

confidence: 99%

Exercise Adherence in Hispanic Adolescents with Obesity or Type 2 Diabetes

Faulkner

Michaliszyn²

2021

Journal of Pediatric Nursing

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Purpose: Hispanic adolescents experience high rates of obesity and type 2 diabetes. The purpose of this study was to examine adherence to a 16-week personalized exercise intervention and the perception of family support for exercise, benefits and barriers to exercise and overall health in Hispanic adolescents diagnosed with obesity or type 2 diabetes. Design and methods: Using a secondary analysis of a larger feasibility trial, data from 21 Hispanic adolescents, 13 with T2D and 8 who were obese and 14 that completed the entire 16-weekstudy (7 T2D;7 obese) were analyzed. Adolescents wore an Actigraph™ accelerometer for tracking exercise throughout the 16-week intervention. Results: The adherence rate for the intervention was 59% for those with T2D and was 88% for those with obesity. Overall perceptions of health improved for those completing the 16-week intervention. Barriers to exercise were negatively associated with moderate-to-vigorous physical activity and were higher in those with T2D. Conclusions: Adolescents with T2D were less adherent to their personalized exercise program than those who were obese. Practice implications: Strategies that address cultural preferences and family engagement are needed to address barriers to exercise for Hispanic youth, particularly those already diagnosed with T2D that have high risks for early onset of disease complications.

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“…At the same time, the unabated increase in childhood obesity is also tightly linked to the emergence of T2D as a new type of pediatric diabetes [92]. Early results from the RISE study show the clinical course is markedly different in adolescents compared to adults suggesting the need for further research to better prevent and manage this unique and increasingly important population [93][94][95][96].…”

Section: Areas For Future Researchmentioning

confidence: 99%

The Continuing Evolution of Precision Health in Type 2 Diabetes: Achievements and Challenges

Lin

Wessel

2019

Curr Diab Rep

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Purpose of Review The purpose of this review was to summarize recent advances in the genomics of type 2 diabetes (T2D) and to highlight current initiatives to advance precision health. Recent Findings Generation of multi-omic data to measure each of the 'biologic layers', developments in describing genomic function and annotation in T2D relevant tissue, along with the increasing recognition that T2D is a heterogeneous disease, and large-scale collaborations have all contributed to advancing our understanding of the molecular basis of T2D. Summary Substantial advances have been made in understanding the molecular basis of T2D pathogenesis, such that precision health diabetes is increasingly becoming a reality. For precision diabetes to become routine in clinical and public health, additional large-scale multiomic initiatives are needed along with better assessment of our environment to delineate an individual's diabetes subtype for improved detection and management.

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Can We RISE to the Challenge of Youth-Onset Type 2 Diabetes?

Cited by 10 publications

References 15 publications

Progress in pediatric obesity: new and advanced therapies

Progress in pediatric obesity: new and advanced therapies

Exercise Adherence in Hispanic Adolescents with Obesity or Type 2 Diabetes

The Continuing Evolution of Precision Health in Type 2 Diabetes: Achievements and Challenges

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