Can we predict development of impulsive–compulsive behaviours in Parkinson’s disease?

Ricciardi, Lucia; Lambert, Christian; Morgante, Francesca; Edwards, Mark J.

doi:10.1136/jnnp-2017-317007

Cited by 20 publications

(20 citation statements)

References 36 publications

(33 reference statements)

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“…However, our results are not entirely consistent with previous research. One study of PD-ICD patients reported no structural differences between PD-ICD and PD-nonICD or HC (96). Recent research brought also evidence of structural differences in orbitofrontal cortex and nucleus accumbens in PD-ICD (47)(48)(49), but our group comparisons were negative regarding these regions.…”

Section: Discussioncontrasting

confidence: 71%

“…For example, PD-ICD patients in the study of Pellicano et al (48), which observed more extensive structural changes than our study, were in more advanced stage and showed more severe disease symptoms than non-impulsive patients. On the other hand, the study of Ricciardi et al (96), which did not find any structural differences, included patients in earlier stage of the disease and with shorter disease duration than our study. Some studies tested patients with mild cognitive impairment (47,49).…”

Section: Discussioncontrasting

confidence: 63%

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Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease

et al. 2020

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Section: Discussioncontrasting

confidence: 71%

Section: Discussioncontrasting

confidence: 63%

Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease

et al. 2020

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“…One study aimed to answer the issue mentioned above whether de novo PD patient who develop ICB have specific structural abnormalities. Patients who went on to develop ICB did not show significant structural changes in comparison to PD patients without ICB ( 89 ). Reduced cortical thickness of fronto-striatal regions but also increased volume of amygdala and a positive correlation between ICB severity and fronto-parietal gray matter volumes has been reported ( 90 , 91 ).…”

Section: Impulse Control Behaviormentioning

confidence: 98%

Structural and Functional Brain Patterns of Non-Motor Syndromes in Parkinson’s Disease

Prell

2018

Front. Neurol.

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Parkinson’s disease (PD) is a common, progressive and multisystem neurodegenerative disorder characterized by motor and non-motor symptoms. Advanced magnetic resonance imaging, positron emission tomography, and functional magnetic resonance imaging can render the view toward understanding the neural basis of these non-motor syndromes, as they help to understand the underlying pathophysiological abnormalities. This review provides an up-to-date description of structural and functional brain alterations in patients with PD with cognitive deficits, visual hallucinations, fatigue, impulsive behavior disorders, sleep disorders, and pain.

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“…In fact, in one account aripiprazole worsened pathological gambling in a PD patient (71). Finally, not all patients using dopaminergic medications report ICDs (72), and conversely, ICDs have been reported in PD patients prior to starting dopaminergic treatments (7, 52, 73). These are all important observations that motivate exploration of ICD associations beyond dopaminergic medications.…”

Section: Medication and Surgical Associationsmentioning

confidence: 99%

Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease

et al. 2019

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Impulse control disorders (ICDs) in Parkinson's disease (PD) have a high cumulative incidence and negatively impact quality of life. ICDs are influenced by a complex interaction of multiple factors. Although it is now well-recognized that dopaminergic treatments and especially dopamine agonists underpin many ICDs, medications alone are not the sole cause. Susceptibility to ICD is increased in the setting of PD. While causality can be challenging to ascertain, a wide range of modifiable and non-modifiable risk factors have been linked to ICDs. Common characteristics of PD patients with ICDs have been consistently identified across many studies; for example, males with an early age of PD onset and dopamine agonist use have a higher risk of ICD. However, not all cases of ICDs in PD can be directly attributable to dopamine, and studies have concluded that additional factors such as genetics, smoking, and/or depression may be more predictive. Beyond dopamine, other ICD associations have been described but remain difficult to explain, including deep brain stimulation surgery, especially in the setting of a reduction in dopaminergic medication use. In this review, we will summarize the demographic, genetic, behavioral, and clinical contributions potentially influencing ICD onset in PD. These associations may inspire future preventative or therapeutic strategies.

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Can we predict development of impulsive–compulsive behaviours in Parkinson’s disease?

Abstract: Worse autonomic and cognitive functions predict development of ICB at the time of PD diagnosis. Structural imaging fails to identify morphological features associated with the development of ICB.

Cited by 20 publications

References 36 publications

Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease

Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease

Structural and Functional Brain Patterns of Non-Motor Syndromes in Parkinson’s Disease

Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease

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