Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease

Hlavatá, Pavlína; Linhartová, Pavla; Šumec, Rastislav; Filip, Pavel; Světlák, Miroslav; Baláž, Marek; Kašpárek, Tomáš; Bareš, Martin

doi:10.3389/fneur.2019.01338

Cited by 22 publications

(31 citation statements)

References 103 publications

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“…For example, predictive processing has been linked to activity of a fronto-parietal network that includes prominently the anterior cingulate, striatum, and insula (Ernst and Paulus, 2005; Krain et al, 2006; Balleine et al, 2007; Kuhns et al, 2017; Siman-Tov et al, 2019; Poudel et al, 2020). In addition, pathological conditions that affect decision-making, such as the increased choice impulsivity in Parkinson’s disease (Nombela et al, 2014), have been associated with functional and neuroanatomical abnormalities of the anterior cingulate and striatum (Gescheidt et al, 2013; Ruitenberg et al, 2018; Hlavatá et al, 2019; Kim and Im, 2019). Moreover, neuroimaging, brain-lesion, and stimulation studies have provided evidence for the association of the left inferior parietal cortex with covert attention to an upcoming movement (Rushworth et al, 2001a; Rushworth et al, 2001b; Rushworth et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Neural encoding of the reliability of directional information during the preparation of targeted movements

Tzagarakis

West

Pellizzer

2020

Preprint

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Visual information about an upcoming target can be used to prepare an appropriate motor response and reduce its reaction time. However, when the anticipation is incorrect and the planned response must be changed, the reaction time is lengthened. Here, we investigated the brain mechanisms associated with the reliability and validity of visual information used for motor preparation. We recorded brain activity using magnetoencephalography (MEG) during a delayed reaching task in which a visual cue provided valid information about the location of the upcoming target with 50, 75 or 100% reliability. We found that reaction time increased as cue reliability decreased and that trials with invalid cues had longer reaction times than trials with valid cues. MEG channel analysis showed that beta-band power from left mid-anterior channels correlated with the reliability of the cue after cue onset but before target onset. This effect was source localized over a large motor-related cortical and subcortical network. In addition, during invalid-cue trials there was a phasic increase of theta-band power following target onset from left posterior channels, localized to the left occipito-parietal cortex. Furthermore, the theta-beta cross-frequency coupling between left mid-occipital and motor cortex also transiently increased before responses to invalid-cue trials. In conclusion, beta-band power in motor-related areas reflected the reliability of visual information used during motor preparation, whereas phasic theta-band activity signaled whether the target was at the expected location or not. These results elucidate mechanisms of interaction between attentional and motor processes.Significance StatementWe used magnetoencephalography to investigate how the brain mechanisms preparing a motor response take into account the reliability of information about the upcoming location of a target to reach, and how these mechanisms adjust when that information turns out to be incorrect. We found that during the response preparation, the power of motor-related beta-band oscillations changed with the reliability of the visual information. In addition, we found that after the onset of the target the power of the left occipito-parietal theta-band signaled whether the prior information was correct or not. The pattern of activity of the beta-band and theta-band explain the pattern of latency of responses in the task, and demonstrate how attentional and motor processes interact.

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Section: Discussionmentioning

confidence: 99%

Neural encoding of the reliability of directional information during the preparation of targeted movements

Tzagarakis

West

Pellizzer

2020

Preprint

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“…Recently, trait impulsivity without apparent ICD in PD patients has been proposed in several studies 14 – 17 . High impulsivity (HI) is a precursor of ICDs and can also lead to severe ICDs 18 , 19 . While HI may be within the spectrum of ICDs, the underlying pathophysiological mechanism differs between trait impulsivity and ICDs 20 .…”

Section: Introductionmentioning

confidence: 99%

“…For instance, ICD has been associated with increased connectivity between the left subthalamic nucleus and the left parietal operculum, whereas trait impulsivity has been associated with a weak connectivity between the left putamen and the right inferior temporal gyrus 21 . Other studies investigating cortical thickness, tractography, or functional MRI have also reported inconsistent results [5][6][7][19][20][21][22] . One of the causes is that impulsivity contains multifaceted constructs.…”

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confidence: 98%

Increased large-scale inter-network connectivity in relation to impulsivity in Parkinson’s disease

Koh

Kaneoke

Donishi

et al. 2020

Sci Rep

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impulsivity is a neuropsychiatric feature of parkinson's disease (pD). We investigated the pathophysiology of impulsivity in pD using resting-state functional magnetic resonance imaging (rs-fMRI). We investigated 45 patients with idiopathic PD and 21 healthy controls. Based on Barratt Impulsiveness Scale (BIS-11) score, PD patients were classified as higher (PD-HI) or lower impulsivity (pD-Li). functional connectivity (fc) between various large-scale brain networks were analysed using the conn toolbox. fc between the right frontoparietal network (fpn) and medial visual network (MVN) was significantly higher in PD-HI patients than PD-LI patients (false discovery rate [FDR]adjusted p = 0.0315). FC between the right FPN and MVN had a significant positive correlation with total BIS-11 score (FDR-adjusted p = 0.010) and the attentional impulsivity (FDR-adjusted p = 0.046) and non-planning impulsivity subscale scores (fDR-adjusted p = 0.018). On the other hand, motor impulsivity subscale score had a significant negative correlation with the FC between the defaultmode and salience networks (right supramarginal gyrus, fDR-adjusted p = 0.018; anterior cingulate cortex, fDR-adjusted p = 0.027); this trend was observed in healthy controls. The attentional and non-planning impulsivity, regarded as 'cognitive' impulsivity, may be associated with dysfunction in integration of perceptual information and flexible cognitive control in PD.

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“…Of the included 30 papers, 12 evaluated structural alterations [13][14][15][16][17][18][19][20][21][22][23][24], 12 evaluated functional alterations [25][26][27][28][29][30][31][32][33][34][35][36], and 6 included both structural and functional measures [37][38][39][40][41][42]. The study of Hammes et al [18] was included in the structural section only, as no between groups analysis was done in functional alteration analysis.…”

Section: Search Resultsmentioning

confidence: 99%

“…Three studies reported grey matter cortical volume using VBM [13,19,40]. Seven reports explored subcortical volumes for a set of a priori regions of interest using sMRI [14,15,18,24,[38][39][40]. Cth was reported in studies [14,15,18,19,23,24,[37][38][39], and subcortical white matter changes using DTI/DWI were described in further four studies [16,17,20,38].…”

Section: Dopaminergic Replacement Therapy-medicated Pd Patientsmentioning

confidence: 99%

Incentive-driven decision-making networks in de novo and drug-treated Parkinson's disease patients with impulsive-compulsive behaviors: A systematic review of neuroimaging studies

Martini

Tamburin

Biundo

et al. 2020

Parkinsonism & Related Disorders

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Background: In Parkinson's disease (PD), impulsive-compulsive behaviors (ICBs) may develop as side-effect of dopaminergic medications. Abnormal incentive-driven decision-making, which is supported by the cognitive control and motivation interaction, may represent an ICBs signature. This systematic review explored whether structural and/or functional brain differences between PD patients with vs without ICBs encompass incentive-driven decision-making networks.Methods: Structural and functional neuroimaging studies comparing PD patients with and without ICBs, either de novo or medicated, were included.Results: Thirty articles were identified. No consistent evidence of structural alteration both in de novo and medicated PD patients were found. Differences in connectivity within the default mode,the salience and the central executive networks predate ICBs development and remain stable once ICBs are fully developed. Medicated PD patients with ICBs show increased metabolism and cerebral blood flow in orbitofrontal and cingulate cortices, ventral striatum, amygdala, insula, temporal and supramarginal gyri. Abnormal ventral striatum connectivity with anterior cingulate cortex and limbic structures was reported in PD patients with ICBs.Discussion: Functional brain signatures of ICBs in PD encompass areas involved in cognitive control and motivational encoding networks of the incentive-driven decision-making. Functional alterations predating ICBs may be related to abnormal synaptic plasticity in these networks.

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Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease

Cited by 22 publications

References 103 publications

Neural encoding of the reliability of directional information during the preparation of targeted movements

Neural encoding of the reliability of directional information during the preparation of targeted movements

Increased large-scale inter-network connectivity in relation to impulsivity in Parkinson’s disease

Incentive-driven decision-making networks in de novo and drug-treated Parkinson's disease patients with impulsive-compulsive behaviors: A systematic review of neuroimaging studies

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