Can vitamin D supplementation improve grip strength in elderly nursing home residents? A double-blinded controlled trial

Smedshaug, Guro Berge; Pedersen, Jan I.; Meyer, Haakon E.

doi:10.3402/fnr.v51i2.1614

Cited by 3 publications

(8 citation statements)

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“…Fifteen of the 17 studies reported random allocation [23-27, 29-36, 38, 39], with six studies also reporting concealment of treatment allocation [23,27,32,35,38,39]. Twelve of the included studies reported blinding of the assessors to group allocation [23-27, 30, 32-36, 39] and 13 reported blinding of participants [23,24,26,27,29,30,[32][33][34][35][37][38][39]. Intention-to-treat analysis occurred in 13 studies [23-25, 27, 30-36, 38, 39].…”

Section: Resultsmentioning

confidence: 99%

“…Timeframes of the intervention period ranged from 12 weeks to 5 years with the mode being 6 months in duration. Two studies did not state baseline 25(OH)D level [24,29], participants in four studies had baseline 25(OH)D >50 nmol/L [28,30,31,34], the mean baseline 25(OH)D level was 25-50 nmol/L in seven studies [23,25,27,32,33,37,39], and <25 nmol/L in four studies [26,35,36,38]. Baseline 1,25(OH) 2 D was within normal range in the study that used calcitriol as a supplement [28].…”

Section: Interventionmentioning

confidence: 94%

“…Figure 1 details the flow of studies included in the review. A final library of 17 RCTs remained involving 5,072 participants [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39].…”

Section: Data Extraction and Analysismentioning

confidence: 99%

“…Six trials compared vitamin D alone with placebo [26,27,29,32,35,37], four of which used ergocalciferol (D 2 ) [26,27,29,35], and two cholecalciferol (D 3 ) [32,37]. One study compared vitamin D metabolite (calcitriol) with placebo [28].…”

Section: Interventionmentioning

confidence: 99%

“…Grip strength was an outcome in eight studies [23-25, 28, 30, 37-39] and was measured via hand held dynamometry (HHD) in seven studies [24,25,28,30,[37][38][39] and using a vigorimeter in one study [23]. Pinch strength was measured in one study by a pinch gauge [38].…”

Section: Outcome Measuresmentioning

confidence: 99%

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Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis

et al. 2010

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Section: Resultsmentioning

confidence: 99%

Section: Interventionmentioning

confidence: 94%

Section: Data Extraction and Analysismentioning

confidence: 99%

Section: Interventionmentioning

confidence: 99%

Section: Outcome Measuresmentioning

confidence: 99%

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Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis

et al. 2010

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Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis

Rosendahl-Riise

Spielau

Ranhoff

et al. 2016

J Human Nutrition Diet

112

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BackgroundIt has been suggested that vitamin D status or supplementation is important for maintaining or improving muscle strength and mobility in older adults. The study results, however, do not provide consistent results. We therefore aimed to summarise the available evidence systematically, including only studies conducted in community‐dwelling older persons.MethodsA systematic search of the literature was performed in April of 2016. The systematic review includes studies that used vitamin D with or without calcium supplementation as the exposure variable and various measurements of muscle strength and mobility. The meta‐analysis was limited to studies using hand grip strength (HGS) and timed‐up‐and‐go test as the outcome variables.ResultsA total of 15 studies out of 2408 articles from the literature search were included in the systematic review, providing 2866 participants above the age of 65 years. In the majority of studies, no improvement in muscle strength and mobility was observed after administration of vitamin D with or without calcium supplements. In the meta‐analysis, we observed a nonsignificant change in HGS [+0.2 kg (95% confidence interval = −0.25 to 0.7 kg; seven studies)] and a small, significant increase in the timed‐up‐and‐go test [0.3 s (95% confidence interval = 0.1 to 0.5 s; five studies)] after vitamin D supplementation. The meta‐analyses showed a high degree of heterogeneity between the studies.ConclusionsIn conclusion, we observed no improvement in muscle strength after the administration of vitamin D with or without calcium supplements. We did find a small but significant deterioration of mobility. However, this is based on a limited number of studies and participants.

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Vitamin D supplementation to prevent depression and poor physical function in older adults: Study protocol of the D-Vitaal study, a randomized placebo-controlled clinical trial

et al. 2015

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BackgroundDepressive symptoms and decreased physical functioning are interrelated conditions and common in older persons, causing significant individual and societal burden. Evidence suggests that vitamin D supplementation may be beneficial for both mental and physical functioning. However, previous randomized controlled trials have yielded inconsistent results and often had suboptimal designs. This study examines the effect of vitamin D supplementation on both depressive symptoms and physical functioning in a high-risk population of older persons with low vitamin D status.Methods/designThe D-Vitaal study is a randomized, double-blind, placebo-controlled trial investigating the effects of a daily dose of 1200 IU vitamin D3 versus placebo for one year on depressive symptoms and physical functioning (primary outcomes) in older adults. Participants (N = 155, age 60–80 years) were recruited from the general population. Eligibility criteria included the presence of depressive symptoms, ≥1 functional limitation and serum 25-hydroxyvitamin D levels between 15 and 50/70 nmol/L (depending on season). Secondary outcomes include incidence of major depressive disorder, anxiety symptoms, health-related quality of life, cognitive function and cost-effectiveness of the intervention.DiscussionWith this study, we aim to elucidate the effects of vitamin D supplementation on depressive symptoms and physical functioning in older persons who are at high risk of developing more substantial mental and physical problems. If effective, vitamin D supplementation can be a preventive intervention strategy that is easy to implement in the primary care setting.Trial registrationNetherlands Trial Register NTR3845. Registered 6 February 2013.

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Can vitamin D supplementation improve grip strength in elderly nursing home residents? A double-blinded controlled trial

Cited by 3 publications

References 0 publications

Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis

Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis

Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis

Vitamin D supplementation to prevent depression and poor physical function in older adults: Study protocol of the D-Vitaal study, a randomized placebo-controlled clinical trial

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