Can transcranial magnetic stimulation (TMS) facilitate language recovery in chronic global aphasia post-stroke? Evidence from a case study

Georgiou, Anastasios M.; Phinikettos, Ioannis; Giasafaki, Chrysa; Kambanaros, Maria

doi:10.1016/j.jneuroling.2020.100907

Cited by 13 publications

(8 citation statements)

References 38 publications

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“…Performance on categorical language and cognitive data for all participants is reported in Tables 2 and 3 and Figure 3 . Data relating to short-term and long-term effects (up to one-year follow-up) for participant 1 (P1) have been also published previously [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…More recently, it was 15 Behavioural Neurology alleged that two pretherapy probes can track the level of performance and rate of change [41]. In the present study, two baseline measurements were applied to lessen concerns that the observed effects may be due to random variation in subject performance and also to minimize placebo effects [42]. Furthermore, participants were blind to their status of TMS conditioning (real vs. sham) until the end of the study.…”

Section: Discussionmentioning

confidence: 99%

“…All three participants with anomic aphasia exhibited trends of improvement in comprehension (one in the short-term, one in the long-term, and one in the short- and long-term); two showed trends of improvement in reading (one in the short-term and one in the short- and long-term), and two showed trends towards improvement in naming (one in the short-term and one in the long-term). One participant (P1 with global aphasia) showed overall improvements in comprehension and reading at two months and at one-year follow-up [ 42 ] that were sustained two years posttreatment as well. Notably, this was the oldest participant who exhibited severe global aphasia resulting from diffuse left hemispheric lesions that also had the least years of education (i.e., six) compared to the other participants.…”

Section: Discussionmentioning

confidence: 99%

“…However, as direct measurements of brain activation and connectivity were not obtained, no hypotheses could be formulated regarding which model(s) of brain-reorganization best explain(s) the findings. In TMS aphasia research, direct measures of brain activation and connectivity are needed to help with the elucidation of the neuroplastic effects of treatments [ 42 ]. Realistically though, individual fMRI localization is expensive, time consuming, and not available in all aphasia labs.…”

Section: Discussionmentioning

confidence: 99%

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The Effectiveness of Transcranial Magnetic Stimulation (TMS) Paradigms as Treatment Options for Recovery of Language Deficits in Chronic Poststroke Aphasia

Georgiou

Kambanaros

2022

Behavioural Neurology

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Background. In an effort to boost aphasia recovery, modern rehabilitation, in addition to speech and language therapy (SALT), is increasingly incorporating noninvasive methods of brain stimulation. The present study is aimed at investigating the effectiveness of two paradigms of neuronavigated repetitive transcranial magnetic stimulation (rTMS): (i) 1 Hz rTMS and (ii) continuous theta burst stimulation (cTBS) each as a standalone treatment for chronic aphasia poststroke. Methods. A single subject experimental design (SSED) trial was carried out in which six people with aphasia (PWA) were recruited, following a single left hemispheric stroke more than six months prior to the study. Three individuals were treated with 1 Hz rTMS, and the remaining three were treated with cTBS. In all cases, TMS was applied over the right pars triangularis (pTr). Language assessment, with standardized and functional measures, and cognitive evaluations were carried out at four time points: twice prior to treatment (baseline), one day immediately posttreatment, and at follow-up two months after treatment was terminated. Quality of life (QoL) was also assessed at baseline and two months posttreatment. In addition, one of the participants with severe global aphasia was followed up again one and two years posttherapy. Results. For all participants, both rTMS paradigms (1 Hz rTMS and cTBS) generated trends towards improvement in several language skills (i.e., verbal receptive language, expressive language, and naming and reading) one day after treatment and/or two months after therapy. Rated QoL remained stable in three individuals, but for the other three, the communication scores of the QoL were reduced, while two of them also showed a decline in the psychological scores. The participant that was treated with cTBS and followed for up to two years showed that the significant improvement she had initially exhibited in comprehension and reading skills two months after TMS (1st follow-up) was sustained for at least up to two years. Conclusion. From the current findings, it is suggested that inhibitory TMS over the right pTr has the potential to drive neuroplastic changes as a standalone treatment that facilitates language recovery in poststroke aphasia.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Effectiveness of Transcranial Magnetic Stimulation (TMS) Paradigms as Treatment Options for Recovery of Language Deficits in Chronic Poststroke Aphasia

Georgiou

Kambanaros

2022

Behavioural Neurology

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“…Most trials have investigated the effects of LF TMS over the contralesional inferior frontal gyrus (IFG) followed by SALT. The therapeutic potential of LF rTMS has also been reported as a standalone treatment e.g., [ 80 , 81 , 82 ]. Studies using HF rTMS on perilesional tissue in the left frontal regions [ 83 , 84 , 85 ] or the left dorsolateral prefrontal cortex (DLPFC) [ 86 ] are also promising for language and cognitive gains post-stroke.…”

Section: Post-stroke Aphasia Therapiesmentioning

confidence: 99%

Therapies and Challenges in the Post-Stroke Aphasia Rehabilitation Arena: Current and Future Prospects

Georgiou,

Kambanaros

2023

Medicina

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Aphasia is a serious consequence of stroke that results in a breakdown in communication. The course of aphasia recovery differs between afflicted individuals, and responsiveness to treatment cannot be predicted. Aphasiologists continue to investigate numerous behavioral treatment protocols that have shifted their focus to complimentary rehabilitation strategies. The aim of this study is threefold. First, to summarize the different categories of aphasia interventions post-stroke, considering their respective protocols, and present available evidence on the effectiveness of those protocols. Second, to document the challenges regarding the prediction of aphasia treatment response post-stroke in individual patients. Third, to report the challenges faced by researchers in recruiting people with aphasia (PWA) for treatment studies, and provide recommendations on how to increase participant recruitment and retention. This study provides up-to-date information on (i) effective therapies and aphasia recovery processes, and (ii) research recruitment hurdles together with potential strategies for overcoming them.

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Neuropsychological and Anatomical-Functional Effects of Transcranial Magnetic Stimulation in Post-Stroke Patients with Cognitive Impairment and Aphasia: A Systematic Review

Pezoa–Peña,

Julio–Ramos,

Cigarroa

et al. 2024

Neuropsychol Rev

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Can transcranial magnetic stimulation (TMS) facilitate language recovery in chronic global aphasia post-stroke? Evidence from a case study

Cited by 13 publications

References 38 publications

The Effectiveness of Transcranial Magnetic Stimulation (TMS) Paradigms as Treatment Options for Recovery of Language Deficits in Chronic Poststroke Aphasia

The Effectiveness of Transcranial Magnetic Stimulation (TMS) Paradigms as Treatment Options for Recovery of Language Deficits in Chronic Poststroke Aphasia

Therapies and Challenges in the Post-Stroke Aphasia Rehabilitation Arena: Current and Future Prospects

Neuropsychological and Anatomical-Functional Effects of Transcranial Magnetic Stimulation in Post-Stroke Patients with Cognitive Impairment and Aphasia: A Systematic Review

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