Can topical cefazolin be a useful treatment for psoriasis?

Kołt-Kamińska, Marta; Koziak, Katarzyna; Dutkiewicz, Małgorzata; Zegrocka-Stendel, Oliwia; Reich, Adam

doi:10.5603/fd.a2020.0005

Cited by 2 publications

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“…Among the factors that motivate us to search for new modalities of local treatment is the inconvenience of daily use of anthralin ointment, as well as the growing tendency to demonstrate steroid phobia in some patients, and the addiction and overuse of topical corticosteroids in others. Recently, we tested topical cefazolin as a potential antipsoriatic alternative to topical corticosteroids [ 4 ]. Here, we want to present data on the use of a novel 650-microsecond 1064 Nd:YAG laser in the treatment of psoriatic plaques.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Mild-to-Moderate Plaque Psoriasis with a New 650-Microsecond 1064-nm Nd:YAG Laser: Clinical and Dermoscopic Assessment

Kołt-Kamińska

Żychowska

Reich

2021

Dermatol Ther (Heidelb)

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Introduction About 70–80% of patients with psoriasis suffer from mild disease, and new modalities of topical treatment are urgently needed. This study aims to evaluate the effectiveness of 650-microsecond 1064-nm Nd:YAG laser in the therapy of psoriatic plaques and assess the utility of dermoscopy in predicting treatment response. Methods Ten patients (mean age 37.4 ± 16.2 years) with stable plaque-type psoriasis were enrolled. The microsecond Nd:YAG laser treatment was applied to representative plaques on day 0, 7, 14, and 21. Clinical and dermoscopic photographs were performed at each session and follow-up visit (day 28). The disease severity was assessed using modified Psoriasis Area and Severity Index (mPASI) and Investigator Global Assessment (IGA). Patients were asked to rate the intensity of subjective symptoms, tolerability, and final outcome of the treatment. Results Significant improvement of all mPASI components was observed, although the maximal mean reduction of total mPASI was only 30.3%. At baseline, three patients were assessed as “moderate” and seven as “mild” according to IGA, while on day 28, eight patients were scored as “mild” and two as “almost clear.” Complete resolution of itching was achieved in all patients. Local adverse reactions were also observed, which resulted in moderate tolerance of treatment in four patients. Three participants reported marked improvement on day 28, although 30% of patients observed no benefit. All subjects with dotted vessels, linear vessels, or hemorrhagic spots under dermoscopy at baseline reported some improvement after laser therapy. Three out of six patients with globular vessels were unresponsive to Nd:YAG laser. Conclusions Microsecond Nd:YAG laser treatment may provide some improvement of psoriatic plaques, but its routine applicability seems to be limited due to ambiguous efficacy and local adverse reactions. Dermoscopy may be useful in identifying patients who will benefit from the procedure.

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Section: Introductionmentioning

confidence: 99%

Treatment of Mild-to-Moderate Plaque Psoriasis with a New 650-Microsecond 1064-nm Nd:YAG Laser: Clinical and Dermoscopic Assessment

Kołt-Kamińska

Żychowska

Reich

2021

Dermatol Ther (Heidelb)

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New, Low–Molecular Weight Chemical Compounds Inhibiting Biological Activity of Interleukin 15

et al. 2023

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Chronic overproduction of IL–15 contributes to the pathogenesis of numerous inflammatory and autoimmune disorders. Experimental methods used to reduce the cytokine activity show promise as potential therapeutic approaches to modify IL–15 signaling and alleviate the development and progression of IL–15–related diseases. We previously demonstrated that an efficient reduction of IL–15 activity can be obtained by selective blocking of the specific, high affinity subunit alpha of the IL–15 receptor (IL–15Rα) with small–molecule inhibitors. In this study, we determined the structure–activity relationship of currently known IL–15Rα inhibitors in order to define the critical structural features required for their activity. To validate our predictions, we designed, analyzed in silico, and assessed in vitro function of 16 new potential IL–15Rα inhibitors. All newly synthesized molecules were benzoic acid derivatives with favorable ADME properties and they efficiently reduced IL–15 dependent peripheral blood mononuclear cells (PBMCs) proliferation, as well as TNF–α and IL–17 secretion. The rational design of IL–15 inhibitors may propel the identification of potential lead molecules for the development of safe and effective therapeutic agents.

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Can topical cefazolin be a useful treatment for psoriasis?

Cited by 2 publications

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Treatment of Mild-to-Moderate Plaque Psoriasis with a New 650-Microsecond 1064-nm Nd:YAG Laser: Clinical and Dermoscopic Assessment

Treatment of Mild-to-Moderate Plaque Psoriasis with a New 650-Microsecond 1064-nm Nd:YAG Laser: Clinical and Dermoscopic Assessment

New, Low–Molecular Weight Chemical Compounds Inhibiting Biological Activity of Interleukin 15

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