Can the Mean Platelet Volume Be a Risk Factor for Vasculogenic Erectile Dysfunction?

Abstract

PurposeThe mean platelet volume (MPV) is a marker of the platelet activity and is reported to increase in vascular diseases. We aimed to investigate the association between MPV and vasculogenic erectile dysfunction (ED).Materials and MethodsMPV and platelet (PLT) levels were measured in 50 cases of ED and 40 healthy controls. The diagnosis of vasculogenic ED was based on a detailed sexual history, physical examination, laboratory assessment, and color Doppler ultrasonography. The results are given as mean±standard deviation of the mean.ResultsThe mean ages of the patient and the control groups were 53.70±12.39 years (range 24~77 years) and 53.85±9.5 years (range 30~73 years), respectively (p=0.947). The MPV and PLT values were significantly higher in the patients with ED than those of the controls (7.49±1.4), (6.85±1.2), (262.97±68), (252.89±82) respectively, p<0.001). However, the MPV values were not statistically significantly different in the patients with severe ED according to the International Index of Erectile Function than in those with mild ED, p>0.05), and there was no correlation between MPV and either age of patients (p=0.905) or duration of ED (p=0.583).ConclusionsThe platelet count and MPV was detected to be increased in patients with vasculogenic ED. This finding suggests a role for platelets in the pathogenesis of vascular complications and that the MPV would be useful in monitoring disease progression.

Ischemic priapism: Can eosinophil count and platelet functions be positive predictive factors in etiopathogenesis

“…7,8,[16][17][18][19][20] The basis of our study was the suspicion that platelet activation and EC are predictive factors for damaged venoocclusive mechanism and endothelial damage, which has a role in ischemic pathophysiology.…”

“…It is known to be connected to the atherosclerosis process in penile arterial deficiency. [5][6][7][8] As seen in many studies, platelets play an active role in vascular pathologies. Eosinophils activate the coagulation system and thrombocytes.…”

“…The relation between vascularsourced disorder and platelet activation has been examined in various studies, 5,6 with some claiming that a relationship does in fact exist between eosinophilia and vascular dysfunction. It is known that eosinophils plays an important role in [7][8][9] Thus, eosinophil count (EC) and PC demonstrating platelet activation and MPV may play a positive role in damages that occur in vascular endothelium and the venoocclusive mechanisms that may cause IP.…”

Mean platelet volume and platelet distribution as a diagnostic marker for penile vascular disease in patients with erectile dysfunction

“…16 MPV increased in ED, however no studies up to date have investigated the relation of PDW with ED. 15,17 In our study, we found higher MPV and PDW in patients who had vascular insufficiency in CDUS (p = 0.011 and p < 0.001; respectively). The difference between the groups for MPV was in correlation with the previous studies.…”

“…The difference between the groups for MPV was in correlation with the previous studies. 15,17 Ciftci et al performed a study on 50 patients and 40 controls, and reported that they did not find any correlation of MPV with age of the patient or disease duration. 17 In our study, a correlation was found between the age of the patient and MPV (r = 0.286, p = 0.006).…”