Can the idealized voider derived flow indexes be a measure of voiding efficiency and how accurate are they?

Introduction: Lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and hypogonadism are frequently encountered in aging males. Our objective was to determine if the presence of metabolic risk factors can be associated with LUTS or total testosterone (TT) levels. Methods: A total of 1087 adult males (≥45 years) who participated in an annual public event (2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018) were recruited. Participants completed the IPSS, IIEF-5, ADAM, and OAB questionnaires. Systolic/diastolic blood pressure (sBP/dBP), neck/ waist circumference, hip length, weight, and height were taken. Total cholesterol, triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), PSA, and TT were collected. Participants were categorized as per TT (low <230 ng/dL, intermediate 230-346 ng/dL, and normal ≥346 ng/dL) and IPSS (mild [0-7], moderate [8][9][10][11][12][13][14][15][16][17][18][19], and severe [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]). A metabolic risk score was created: 1 point for each criterion (BMI ≥30, TG >1.7 mmol/L, sBP ≥130, dBP ≥85, HDL <1.03 mmol/L). ANOVA regressions were performed for the metabolic score assessment (Prism 9). Results: Median age was 59 years old. TT was ≥346 ng/dL in 36%, 39%, and 39% in patients with mild, moderate, and severe LUTS, respectively. A total of 31% of participants had BMI ≥30, 42% had high TG, 23% had low HDL levels, 76% had high sBP, and 45% had elevated dBP. There was no association between metabolic risk score and IPSS (p=0.3995) or IIEF-5 scores (p=0.7367). TT category and metabolic score were associated (ANOVA, p=0.0001). A metabolic score of ≥2/5 was associated with TT <230 ng/dL. A score of ≥3/5 was associated with PSA of ≥2 ng/mL, while a score of ≤2/5 was associated with PSA <1 ng/mL. Conclusions: This cross-sectional analysis indicated an association of various metabolic derangements (BMI ≥30, TG >1.7 mmol/L, sBP ≥130, dBP ≥85, HDL <1.03 mmol/L) with serum TT and PSA levels, but not with LUTS. Further investigations are required to evaluate the potential health risks of hypogonadism in these individuals and if early diagnosis and interventions on the hypogonadal state can benefit them.

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Can the idealized voider derived flow indexes be a measure of voiding efficiency and how accurate are they?

Abstract: The data support both of our hypothesis that flow index is a good measure of voiding efficiency. We have also shown that IVFE is a better and more accurate measure of calculating a flow index than the power equations regardless of the volume and PVR scenarios that are presented.

Cited by 3 publications

References 9 publications

Voiding efficiency in children is significantly impaired by the presence of the urethral catheter during pressure-flow studies

Voiding efficiency in children is significantly impaired by the presence of the urethral catheter during pressure-flow studies

A comparison of 467 uroflowmetry results in repaired hypospadias vs. normal male flows

Poster Session 10: Sexual Health, Pediatrics

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