Can ‘search and destroy’ reduce nosocomial meticillin-resistant Staphylococcus aureus in an Irish hospital?

Higgins, Ann; Lynch, Maureen; Gethin, Georgina

doi:10.1016/j.jhin.2009.12.014

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…These strategies could also be useful for other countries with higher MRSA prevalence. Ireland adopted an approach based on search and destroy to combat MRSA in hospitals 10 . The low prevalence of MRSA colonization found in nursing home residents in this study supports continued vigilance and monitoring, particularly in border areas, to keep MRSA under control in Dutch nursing homes.…”

mentioning

confidence: 57%

LOW PREVALENCE OF METHICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS IN DUTCH NURSING HOMES

Greenland¹,

Rijnders²,

Mulders³

et al. 2011

J American Geriatrics Society

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mentioning

confidence: 57%

LOW PREVALENCE OF METHICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS IN DUTCH NURSING HOMES

Greenland¹,

Rijnders²,

Mulders³

et al. 2011

J American Geriatrics Society

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“…This strategy may be among the reasons explaining the very low prevalence of MRSA in The Netherlands [64]. The search and destroy strategy has also produced favourable outcomes in Ireland, Denmark, and other Scandinavian countries [82,83]. Similar strategies are now used more widely not only for MRSA, but also for resistant Gram-negative bacteria producing ESBL or carbapenemases [69-74].…”

Section: Are There Methods To Prevent or Treat Gut Colonisation With mentioning

confidence: 99%

The gut is the epicentre of antibiotic resistance

Carlet

2012

Antimicrob Resist Infect Control

174

141

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The gut contains very large numbers of bacteria. Changes in the composition of the gut flora, due in particular to antibiotics, can happen silently, leading to the selection of highly resistant bacteria and Candida species. These resistant organisms may remain for months in the gut of the carrier without causing any symptoms or translocate through the gut epithelium, induce healthcare-associated infections, undergo cross-transmission to other individuals, and cause limited outbreaks. Techniques are available to prevent, detect, and treat the carriage of resistant organisms in the gut. However, evidence on these techniques is scant, the only exception being selective digestive decontamination (SDD), which has been extensively studied in neutropenic and ICU patients. After the destruction of resistant colonizing bacteria, which has been successfully obtained in several studies, the gut could be re-colonized with normal faecal flora or probiotics. Studies are warranted to evaluate this concept.

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“…The spread of hospital-acquired infections (HAI) has been mainly studied at the level of single hospitals [1], [2], as most investigators have focussed on the immediate causes of nosocomial transmission [3], [4]. These causes consist of a mix of risk factors which are pathogen–, patient– and health care-related [5].…”

Section: Introductionmentioning

confidence: 99%

Hospital Networks and the Dispersal of Hospital-Acquired Pathogens by Patient Transfer

Donker

Wallinga

Slack³

et al. 2012

PLoS ONE

114

117

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Hospital-acquired infections (HAI) are often seen as preventable incidents that result from unsafe practices or poor hospital hygiene. This however ignores the fact that transmissibility is not only a property of the causative organisms but also of the hosts who can translocate bacteria when moving between hospitals. In an epidemiological sense, hospitals become connected through the patients they share. We here postulate that the degree of hospital connectedness crucially influences the rates of infections caused by hospital-acquired bacteria. To test this hypothesis, we mapped the movement of patients based on the UK-NHS Hospital Episode Statistics and observed that the proportion of patients admitted to a hospital after a recent episode in another hospital correlates with the hospital-specific incidence rate of MRSA bacteraemia as recorded by mandatory reporting. We observed a positive correlation between hospital connectedness and MRSA bacteraemia incidence rate that is significant for all financial years since 2001 except for 2008–09. All years combined, this correlation is positive and significantly different from zero (partial correlation coefficient r = 0.33 (0.28 to 0.38)). When comparing the referral pattern for English hospitals with referral patterns observed in the Netherlands, we predict that English hospitals more likely see a swifter and more sustained spread of HAIs. Our results indicate that hospitals cannot be viewed as individual units but rather should be viewed as connected elements of larger modular networks. Our findings stress the importance of cooperative effects that will have a bearing on the planning of health care systems, patient management and hospital infection control.

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Can ‘search and destroy’ reduce nosocomial meticillin-resistant Staphylococcus aureus in an Irish hospital?

Cited by 7 publications

References 28 publications

LOW PREVALENCE OF METHICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS IN DUTCH NURSING HOMES

LOW PREVALENCE OF METHICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS IN DUTCH NURSING HOMES

The gut is the epicentre of antibiotic resistance

Hospital Networks and the Dispersal of Hospital-Acquired Pathogens by Patient Transfer

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