Can proteomics-based approaches further help COVID-19 prevention and therapy?

Exploring COVID-19 pathogenesis on command-line: A bioinformatics pipeline for handling and integrating omics data

“…The intra-patient comparison at different time points showed there is an activation of the immune system, especially of pathways linked to leukocytes in the first 24 h. However, these responses are diminished after 14 days. Other studies also reported the ability of the plasma and serum proteome to reflect the action of the immune system in the infection ( Arthur et al, 2021 ; Kumar, 2021 ; Villar et al, 2021 ; Zhong et al, 2021 ). Among the immune system proteins that stood out were C1QA, which is crucial in the activation of the classical pathway of the complement system ( Ghebrehiwet, Hosszu, Valentino, & Peerschke, 2012 ; Kouser et al, 2015 ; Nayak, Pednekar, Reid, & Kishore, 2012 ), and CD93, involved in the regulation of phagocytosis of apoptotic cells in vivo .…”

Serum Proteome Signatures of Anti-SARS-CoV-2 Vaccinated Healthcare Workers in Greece Associated with Their Prior Infection Status

“…Additionally, the cytokine storm was shown to be a pivotal factor of mortality in patients with severe COVID-19, an outcome that can be predicted by SARS-CoV-2 Nsp3 protein analysis [ 8 ]. Further, proteomics analyses have been used to highlight alterations in molecular pathways of SARS-CoV-2 hosts (such as in nucleic acid metabolism), and such approaches can be adopted to mine for COVID-19 severity biomarkers, promote new treatment options and lead to future therapies through phosphoproteomics, glycoproteomics, and lipoproteomics [ 9 ].…”