Can pretreatment computed tomography predict local control in T3 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy?

Voice, swallowing, and quality of life after total laryngectomy—Results of the west of Scotland laryngectomy audit

“…It has been demonstrated that tumor volume is a significant predictor of outcome for T3 glottic disease treated with radical radiotherapy. 18 Published United Kingdom protocols advocate management with primary organ preservation for low-volume T3 laryngeal disease and primary total laryngectomy for high-volume T3 disease with an emphasis on patient choice and performance status.…”

Interobserver reliability of computed tomography‐derived primary tumor volume measurement in patients with supraglottic carcinoma

“…4 Numerous studies have shown that the macroscopic ("gross") tumor volume (GTV) at the primary site, as calculated from pretreatment computed tomography (CT) scans, can predict local control in squamous cell carcinoma (SCC) arising in different subsites of the head and neck in patients who are treated with definitive radiation therapy (RT). [5][6][7][8][9][10][11][12][13][14][15][16][17] Larger volume tumors have a higher likelihood of local recurrence than smaller volume lesions arising in the same anatomic subsite. [5][6][7][8][9][10][11][12][13][14][15][16][17] Threshold volumes have been identified in nasopharyngeal, oropharyngeal, supraglottic, pyriform sinus, and T3 glottic carcinomas.…”

“…[5][6][7][8][9][10][11][12][13][14][15][16][17] Larger volume tumors have a higher likelihood of local recurrence than smaller volume lesions arising in the same anatomic subsite. [5][6][7][8][9][10][11][12][13][14][15][16][17] Threshold volumes have been identified in nasopharyngeal, oropharyngeal, supraglottic, pyriform sinus, and T3 glottic carcinomas. [5][6][7][8][9][10][11][12][13][14][15][16][17] Several investigators also have shown that there is a stronger association between GTV and local control than the association between T classification and local control.…”

“…[5][6][7][8][9][10][11][12][13][14][15][16][17] Threshold volumes have been identified in nasopharyngeal, oropharyngeal, supraglottic, pyriform sinus, and T3 glottic carcinomas. [5][6][7][8][9][10][11][12][13][14][15][16][17] Several investigators also have shown that there is a stronger association between GTV and local control than the association between T classification and local control. 6,7,[15][16][17][18] This additional information helps physicians to counsel patients regarding the relative likelihood of local tumor control with primary surgery or RT with or without chemotherapy.…”

Accelerated radiotherapy for advanced laryngeal cancer

“…One can assume that tumors with extension to other tissues beyond the larynx in most cases are large volume tumors, and a large tumor volume has been shown to be a negative prognostic factor for the outcome of RT [22,23]. Tumors classified as T4 due to cartilage invasion on CT or MRI, however, could represent either a large or a low tumor volume.…”