Can preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios be used as predictive markers for lymph node metastasis in squamous cell carcinoma of the vulva?

Ertaş, İbrahim Egemen; Güngördük, Kemal; Akman, Levent; Ozdemir, Aykut; Terek, Mustafa Coşan; Özsaran, Aydın; Şancı, Muzaffer; Dikmen, Yılmaz

doi:10.1016/j.ejogrb.2013.08.023

Cited by 32 publications

(41 citation statements)

References 29 publications

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“…There is growing evidence of an association between PLR and unfavorable outcomes of patients with various cancers including gynecologic malignancy (Smith et al, 2009;Asher et al, 2011;Raungkaewmanee et al, 2012;Ertas et al, 2013;Liu et al, 2013;Rassouli et al, 2013;Unal et al, 2013;Wang et al, 2013). For example, Wang et al (2013) reported that PLR was directly correlated with risk of encountering cervical stromal invasion among women with endometrioid adenocarcinoma of the endometrium.…”

Section: Discussionmentioning

confidence: 99%

“…For example, Wang et al (2013) reported that PLR was directly correlated with risk of encountering cervical stromal invasion among women with endometrioid adenocarcinoma of the endometrium. For women with squamous cell carcinoma of the vulva, an elevated preoperative PLR increases the risk of having lymph node metastasis (Ertas et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies indicated that preoperative hematologic parameters obtained from complete blood count (CBC) might serve as prognostic biomarkers for many types of cancers (Halazun et al, 2008;Smith et al, 2009;Asher et al, 2011;Raungkaewmanee et al, 2012;Allensworth et al, 2013;Ertas et al, 2013;Liu et al, 2013;Njolstad et al, 2013;Rassouli et al, 2013;Unal et al, 2013;Wang et al, 2013) CBC is an easy, inexpensive, routine preoperative investigation, so no extra cost would be incurred for its use. The preoperative platelet to lymphocyte ratio (PLR)-a novel and valuable platelet index-is known to be associated with survival outcomes of various cancers including gynecologic ones (Smith, et al, 2009;Asher et al, 2011;Raungkaewmanee, et al, 2012;Ertas, et al, 2013;Liu, et al, 2013;Rassouli, et al, 2013;Unal, et al, 2013;.…”

Section: Introductionmentioning

confidence: 99%

“…The preoperative platelet to lymphocyte ratio (PLR)-a novel and valuable platelet index-is known to be associated with survival outcomes of various cancers including gynecologic ones (Smith, et al, 2009;Asher et al, 2011;Raungkaewmanee, et al, 2012;Ertas, et al, 2013;Liu, et al, 2013;Rassouli, et al, 2013;Unal, et al, 2013;. In 2011, Asher et al (2011) were the first to demonstrate the significant independent impact of elevated PLR on survival of women with EOC.…”

Section: Introductionmentioning

confidence: 99%

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Elevated Preoperative Platelet to Lymphocyte Ratio Associated with Decreased Survival of Women with Ovarian Clear Cell Carcinoma

Supoken¹,

Kleebkaow²,

Chumworathayi³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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This study was conducted to establish whether the preoperative platelet to lymphocyte ratio (PLR) is predictive of survival of women with ovarian clear cell carcinoma (OCCC). A PLR > 300 was deemed elevated. Progression-free survival (PFS) was estimated using the Kaplan-Meier method. Cox proportional hazard analysis was used to determine the independent effect of PLR. Thirty-six patients were reviewed. Elevated PLRs were more commonly noted in patients with an advanced vs an early stage of disease (88.9% vs 11.1%). Women with elevated PLR carried a higher rate of disease progression during primary therapy than that those in the normal PLR group (44.4 vs 22.2%). The median PFS for patients with elevated PLR was notably worse than that for patients with normal PLR (10 vs 34 months). Despite the impact of elevated PLR on PFS, it was found to be marginally significant when controlling for commonly applied prognostic markers. It, however, trended toward significance (HR=4.76; 95%CI, 0.95-23.8). In conclusion, an elevated PLR appears to be directly associated with adverse survival rather than being a surrogate for other indicators of a poor prognosis. PLR may be a useful biomarker for predicting survival of women with OCCC and merits further large-scale studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Elevated Preoperative Platelet to Lymphocyte Ratio Associated with Decreased Survival of Women with Ovarian Clear Cell Carcinoma

Supoken¹,

Kleebkaow²,

Chumworathayi³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Such inflammatory setting could favor tumor progression while modifying levels of routine blood parameters such as C-reactive protein (CRP), leukocytes and derivatives. Several studies reported neutrophil-to-lymphocyte ratio (NLR), that combines neutrophils and lymphocytes, as a predictive factor for the presence of lymph node metastasis or non-organ-confined (NOC) disease in vulva squamous cell carcinoma [8] and in bladder cancer [9], respectively. Other studies demonstrated its prognostic value in pancreatic cancer, colon cancer or breast cancer [10].…”

Section: Introductionmentioning

confidence: 99%

804 Promising role of preoperative neutrophil-to-lymphocyte ratio in patients treated with radical nephroureterectomy

Vartolomei¹,

Mathiéu²,

Rouprêt³

et al. 2016

European Urology Supplements

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the association between NLR and lymph node metastasis, muscle-invasive and non-organ-confined disease. The association of altered NLR with recurrence-free survival (RFS) and cancer-specific survival (CSS) was evaluated using Cox proportional hazards regression models. Results Altered NLR was observed in 1428 (62.8 %) patients and associated with more advanced pathological tumor stage, lymph node metastasis, lymphovascular invasion, tumor necrosis and sessile tumor architecture. In a preoperative model that included age, gender, tumor location and architecture, NLR was an independent predictive factor for the presence of lymph node metastasis, muscle-invasive and non-organ-confined disease AbstractObjective Several retrospective studies with small cohorts reported neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker in upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU). We aimed at validating the predictive and prognostic role of NLR in a large multi-institutional cohort. Methods Preoperative NLR was assessed in a multiinstitutional cohort of 2477 patients with UTUC treated with RNU. Altered NLR was defined by a ratio >2.7. Logistic regression analyses were performed to assess Mihai Dorin Vartolomei and Romain Mathieu have contributed equally as co-first authors.

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Neutrophil‐lymphocyte and platelet‐lymphocyte ratio as predictors of disease specific survival after resection of adrenocortical carcinoma

Bagante

Tran

Postlewait

et al. 2015

Journal of Surgical Oncology

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Can preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios be used as predictive markers for lymph node metastasis in squamous cell carcinoma of the vulva?

Cited by 32 publications

References 29 publications

Elevated Preoperative Platelet to Lymphocyte Ratio Associated with Decreased Survival of Women with Ovarian Clear Cell Carcinoma

Elevated Preoperative Platelet to Lymphocyte Ratio Associated with Decreased Survival of Women with Ovarian Clear Cell Carcinoma

804 Promising role of preoperative neutrophil-to-lymphocyte ratio in patients treated with radical nephroureterectomy

Neutrophil‐lymphocyte and platelet‐lymphocyte ratio as predictors of disease specific survival after resection of adrenocortical carcinoma

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