Can Pre-Neoplastic Lesions be Detected in Gastric Biopsies of Children with Helicobacter pylori Infection?

Guarner, Jeannette; Bartlett, Jeanine; Whistler, Toni; Pierce-Smith, Daphne L.; Owens, Marilyn; Kreh, Rachel; Czinn, Steven J.; Gold, Benjamin D.

doi:10.1097/00005176-200309000-00019

Cited by 56 publications

(61 citation statements)

References 18 publications

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“…Similar changes have been observed in previous studies that evaluated the apoptosis of gastric mucosa inflammatory cells showing an increased apoptosis of CD4 + T-cell subset using immunohistochemistry methods [Guarner et al, 2003, Kotłowska-Kmieć et al, 2009.…”

Section: Discussionsupporting

confidence: 86%

“…The majority of the infected children do not suffer from acute inflammatory complications and a few develop severe diseases such as peptic ulcer (Queiroz et al, 1991), mucosal atrophy, gastric carcinoma or MALT lymphoma (Guarner et al, 2003). The cellular basis for the mild gastric inflammatory changes in children with H. pylori infection is poorly understood.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lymphocyte Apoptosis, Proliferation and Cytokine Synthesis Pattern in Children with Helicobacter pylori Infection

Helmin-Basa¹,

Gackowska²,

Kubiszewska³

et al. 2012

Clinical Flow Cytometry - Emerging Applications

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Lymphocyte Apoptosis, Proliferation and Cytokine Synthesis Pattern in Children with Helicobacter pylori Infection

Helmin-Basa¹,

Gackowska²,

Kubiszewska³

et al. 2012

Clinical Flow Cytometry - Emerging Applications

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“…Bacterial overgrowth may be more frequent. In contrast to adults, preneoplastic lesions are exceptional (193), even in high risk areas (465). The infection is seldomly found in infants and young children, which limits the possibilities of test comparisons on large series.…”

Section: Application In Different Clinical Settingsmentioning

confidence: 99%

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

2007

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SUMMARY The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.

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“…Guarner et al have observed gastric atrophy in 8, intestinal metaplasia in 2 and both in 2 patients out of 19 children. 15 All children were infected with H.pylori and all patients with intestinal metaplasia were older than 9 years. Atrophy was seen in 10 patients, all in the antrum, and metaplasia in 4 patients, 3 in the antrum and 1 in the corpus.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Metaplasia and Gastric Atrophy in Children is not as Frequent as Adults

Uğraş¹,

Alan²

2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Atrophic gastritis and intestinal metaplasia are frequently seen among adult patients and are thought to be premalignant. The prevalence of these lesions among children is not well known. The aim of the study is to investigate the prevalence of gastric atrophy and intestinal metaplasia in children. M Ma at te er ri ia al l a an nd d a an nd d M Me et th ho od ds s: Children with gastrointestinal symptoms admitted to our clinic were evaluated. The data about urea breath test, upper gastrointestinal endoscopy macroscopical findings and histopathological evaluation with modified Sydney classification were evaluated retrospectively from patient records. R Re es su ul lt ts s: : A total of 357 children underwent upper gastrointestinal system endoscopy. Histopathological evaluation revealed no gastric atrophy but intestinal metaplasia in 2 children. Both of the children had positive urea breath test, gastritis and were positive for Helicobacter pylori histologically. One of these children also had a peptic ulcer. The children underwent endoscopy again after H.pylori eradication therapy, and intestinal metaplasia was not seen on the biopsy materials. C Co on nc cl lu us si io on n: : Precancerous lesions are very rarely reported among children. These are particularly seen together with H. pylori infection and around 10-years of age. Our results show that intestinal metaplasia is seen in H.pylori positive children and the incidence is very low. The reason of low prevalence is suggested to be depending on the host, microorganism and the pathologists. K Ke ey y W Wo or rd ds s: : Helicobacter pylori; child; metaplasia Ö ÖZ ZE ET T A Am ma aç ç: : Atrofik gastrit ve intestinal metaplazi erişkinlerde sık görülen ve premalign potansiyeli olan lezyonlardır. Bu lezyonların çocuklardaki prevalansı iyi bilinmemektedir. Çalışmamızın amacı, çocuklarda gastrik atrofi ve intestinal metaplazi prevalansını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Kliniğimize gastrointestinal sistem bulguları ile başvuran hastalar çalışmaya alındı. Bu hastaların üre nefes testi, üst gastrointestinal sistem endoskopisindeki makroskopik bulguları ve yeniden düzenlen-miş Sydney sınıflaması ile histolojik sonuçları geriye dönük olarak değerlendirildi. B Bu ul lg gu ul la ar r: : Toplam olarak 357 çocuğa endoskopi yapılmıştı. Histopatolojik değerlendirmede hiç gastrik atrofi saptanmadı, 2 hastada intestinal metaplazi olduğu görüldü. Her ikisinin de hem üre nefes testleri hem de histopatolojik sonuçları ile, Helicobacter pylori pozitifti. Bir hastada peptik ülser görülmüştü. H.pylori eradikasyonu sonrası yapılan tekrar endoskopisinde de intestinal metaplazi saptanmadı. S So on nu uç ç: : Çocuklarda prekanseröz lezyon çok nadir bildirilmiştir. Bu lezyonlar genelde H.pylori enfeksiyonu ile birlikte ve 10'lu yaşlarını süren gençlerde bildirilmiştir. Bizim sonuçlarımıza göre, intestinal metaplazi H.pylori pozitif çocuklarda çok nadiren görülmektedir. Bu düşük prevalansın nedenler...

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Can Pre-Neoplastic Lesions be Detected in Gastric Biopsies of Children with Helicobacter pylori Infection?

Cited by 56 publications

References 18 publications

Lymphocyte Apoptosis, Proliferation and Cytokine Synthesis Pattern in Children with Helicobacter pylori Infection

Lymphocyte Apoptosis, Proliferation and Cytokine Synthesis Pattern in Children with Helicobacter pylori Infection

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

Intestinal Metaplasia and Gastric Atrophy in Children is not as Frequent as Adults

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