Can Photothermal Post-Operative Cancer Treatment Be Induced by a Thermal Trigger?

Chen, Lei; Yu, Qianqian; Cheng, Kai; Topham, Paul D.; Xu, Mengmeng; Sun, Xiaoqing; Pan, Yuanjiang; Jia, Yifan; Wang, Shuo; Wang, Linge

doi:10.1021/acsami.1c16283

Cited by 18 publications

(5 citation statements)

References 62 publications

(91 reference statements)

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“…Tumor-bearing mice were modeled similarly to the previous work [4]. Mice were randomized into 7 groups (n = 6): (G1) Ctrl, (G2) PCFs, (G3) PCF/DOX, (G4) PCF + Laser, (G5) PCF/DOX scaffolds + Laser, (G6) PCF/DOX/Az scaffolds + Laser, and (G7) HCFs + Laser.…”

Section: In Vivo Antitumor Efficacymentioning

confidence: 99%

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Temperature-Regulating Phase Change Fiber Scaffold Toward Mild Photothermal–Chemotherapy

et al. 2022

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Photothermal therapy (PTT) is a treatment that raises the temperature of tumors to 42-48°C, or even higher for tumor ablation. PTT has sparked a lot of attention due to its ability to induce apoptosis or increase sensitivity to chemotherapy. Excessive heat kills tumor cells but also causes harm to surrounding healthy tissue, reducing therapeutic accuracy and increasing side effects. Herein, a phase change fiber (PCF) scaffold that acts as a thermal trigger in mild photothermal-chemo tumor therapy is developed to regulate temperature and control drug release. These prepared PCFs, comprised of hollow carbon fibers (HCFs) loaded with lauric acid as a phase change material (PCM), can effectively store and release any excess heat generated by irradiating with a nearinfrared (NIR) laser through the reversible solid-liquid transition process of the PCM.With this feature, the optimal PTT temperature of implanted PCF-based composite scaffolds was identified for tumor therapy with minimal normal tissue damage. In addition, controlled release of chemotherapeutic drugs and heat shock protein (HSP) inhibitors from the PCF-based composite scaffolds have been shown to improve the efficacy of mild PTT. The developed PCF-based scaffold sheds light on the development of a new generation of therapeutic scaffolds for thermal therapy.

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Section: In Vivo Antitumor Efficacymentioning

confidence: 99%

“…Significant progress has been made in cancer treatment over the last few decades [1]. Among the existing treatment methods, photothermal therapy (PTT) has become a popular treatment because of its minimal biological invasiveness, high convenience, lack of systemic side effects and obvious therapeutic effect [2,3,4,5].…”

Section: Introductionmentioning

confidence: 99%

Temperature-Regulating Phase Change Fiber Scaffold Toward Mild Photothermal–Chemotherapy

et al. 2022

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“…Numerous biodegradable polyesters based on SA have been synthesized, including poly(ethylene succinate), PBS, poly(butylene succinate- co -butylene adipate) (PBSA), perfluorobutanesulfonyl fluoride, and poly(butylene succinate- co -butylene 2,5-thiophenedicarboxylate). ,− SA can effectively control the thermal properties, crystallization ability, and mechanical performance of these polyesters without compromising their biodegradability. Furthermore, PBS containing only BS repeat units is already a commercialized biodegradable material, with established application in the medical field. − …”

Section: Introductionmentioning

confidence: 99%

Modification of Biodegradable Poly(butylene carbonate) with Succinic Acid: High Thermal and Barrier Properties

Zhang,

Hu,

Cai

et al. 2024

ACS Sustainable Resour. Manage.

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Poly(butylene carbonate) (PBC), which originates from carbon dioxide (CO2), is a very important member of the family of biodegradable polymers. In order to enhance the melting point (T m), thermal stability, and barrier properties of PBC, a series of poly(butylene carbonate-co-butylene succinate) (PBCS) random copolyesters with weight-average molecular weights ranging from 79600 to 139800 g/mol were synthesized via melt polycondensation from dimethyl carbonate, succinic acid, and 1,4-butanediol. In detail, the chemical structures and properties were evaluated. The results indicate that the incorporation of butylene succinate (BS) units into the molecular chain of PBC can significantly regulate the thermal transition properties, crystal behavior, and thermal stability. T m of PBC increases from 60.4 to 104.2 °C for PBCS88, and T d,5% rises from 288 to 324 °C. Despite being influenced by crystallinity, mechanical properties do not linearly increase with the rising content of BS units; they remain satisfactory. The maximum barrier properties of PBCSs for CO2 and O2 are respectively 6.3 and 5.5 times greater than those of poly(butylene adipate-co-terephthalate) (PBAT). Impressively, the water vapor barrier is as high as 40.8 times. In addition, PBCSs demonstrate degradation capability in a phosphate-buffered solution, an enzyme environment, and a composting environment, particularly achieving complete degradation within 4–8 days in enzyme environments. This work provides a new strategy to improve the overall properties of PBC, resulting in PBCSs, a renewable and ecofriendly polymer material. By adjustment of the BS unit content, diverse properties can be achieved to meet the demands of application in the packaging, film, and medical fields.

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“…Electrospinning as a facile and generalizable method can produce electrospun nanofibrous patches with homogeneously dispersed nanoparticles, maximizing exposure of the active sites of nanoparticles . The implantable electrospun nanofibrous patch can also combine multiple therapeutic modalities for the synergistic treatment of cancer. − …”

Section: Introductionmentioning

confidence: 99%

Self-Driven Electrical Stimulation-Promoted Cancer Catalytic Therapy and Chemotherapy Based on an Implantable Nanofibrous Patch

Zheng

Yao

Zhao

et al. 2023

ACS Appl. Mater. Interfaces

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The efficacy of cancer catalytic therapy is still hindered by the inefficient generation of reactive oxygen species (ROS). Herein, we report a self-driven electrical stimulation-promoted cancer catalytic therapy and chemotherapy by integrating a human-driven triboelectric nanogenerator (TENG) with an implantable and biodegradable nanofibrous patch. The gelatin/polycaprolactone nanofibrous patch incorporates doxorubicin (DOX) and graphitic carbon nitride (g-C3N4), in which the peroxidase (POD)-like activity of g-C3N4 to produce hydroxyl radical (•OH) can be distinctly enhanced by the self-driven electrical stimulation for 4.12-fold, and simultaneously DOX can be released to synergize the therapy, especially under a weakly acidic tumor microenvironment (TME) condition. The in vitro and in vivo experimental results on a mouse breast cancer model demonstrate superior tumor suppression outcome. The self-powered electrical stimulation-enhanced catalytic therapy and chemotherapy via multifunctional nanofibrous patches proposes a new complementary strategy for the catalytic therapy of solid tumors.

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Can Photothermal Post-Operative Cancer Treatment Be Induced by a Thermal Trigger?

Cited by 18 publications

References 62 publications

Temperature-Regulating Phase Change Fiber Scaffold Toward Mild Photothermal–Chemotherapy

Temperature-Regulating Phase Change Fiber Scaffold Toward Mild Photothermal–Chemotherapy

Modification of Biodegradable Poly(butylene carbonate) with Succinic Acid: High Thermal and Barrier Properties

Self-Driven Electrical Stimulation-Promoted Cancer Catalytic Therapy and Chemotherapy Based on an Implantable Nanofibrous Patch

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