Work and family problems are important in the life of a nurse that causes conflict between work and family. This work-family conflict requires satisfaction in marriage and satisfaction in work. The purpose of this study is to examine the relationship between work-family conflict with marital satiction and between work-family conflict and job satisfaction. This research is survey research. The population in this study were nurses who worked in hospital X in Purwokerto with a sample of 40 people (men = 6 people and 34 women). The instruments used in this study were the scale of work-family conflict, the scale of job satisfaction and scale of marital satisfaction. The results of the data analysis showed a negative and significant contradiction between work-family conflict and marital satisfaction. This means that the higher the workfamily conflict, the lower the marital satisfaction. The same results were also found in conflicts between family work and job satisfaction, namely, there were those who argued negatively and significantly between family work conflicts and job satisfaction. These results can explain how roles in the family and workplace influence each other. Therefore, nurses must balance roles in the family and roles in the workplace to reduce family conflict. Decreased workfamily conflict will ultimately increase satisfaction in marriage and satisfaction in the workplace.