Can Intravenous Feeding as the Sole Means of Nutrition Support Growth in the Child and Restore Weight Loss in an Adult?

Dudrick, Stanley J.; Wilmore, Douglas W.; Vars, Harry M.; Rhoads, Jonathan E.

doi:10.1097/00000658-196906000-00018

Cited by 382 publications

(71 citation statements)

References 3 publications

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“…(b) Certain types of incomplete formula lead to weight gain that consists largely of adipose tissue. Therefore weight gain may be a misleading measure of the effectiveness of hyperalimentation in some patients (35)(36)(37). (c) Hyperalimentation of our starved adults with fluid lacking N or P failed to produce positive balance of K, Na, or Cl.…”

Section: Discussionmentioning

confidence: 95%

Elemental balances during intravenous hyperalimentation of underweight adult subjects.

Rudman¹,

Millikan²,

Richardson³

et al. 1975

J. Clin. Invest.

198

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A B S T R A C T Intravenous hyperalimentation was done in 11 underweight adults whose body weight (body wt) was less than 85% of ideal. For the first 6 days, "complete formula" was infused furnishing per kilogram ideal body wt per day: 15 g glucose, 0.40 g N, 0.018 g P, 2.4 meq K, 3.0 meq Na, 2.3 meq Cl, 0.5 meq Mg, 0.45 meq Ca, and 50 ml H20. Patients gained weight at an average rate of 9.0 g/kg ideal body wt/day and showed average balances/kilogram ideal body wt/day as follows: + 0.14 g N; + 0.012 g P; + 0.43 meq K; + 0.49 meq Na; + 0.37 meq Cl; and + 0.085 meq Ca. Application of standard equations to the elemental balances indicated weight gain consisted of 35-50% protoplasm, 35-50% extracellular fluid, 5-25% adipose tissue, and < 1% bone.Withdrawal of N, P, Na, or K impaired or abolished retention of other elements. Removal of N halted retention of P, K, Na, and Cl; withdrawal of K stopped retention of N and P; and removal of Na or P interrupted retention of all other elements. Weight gain continued at a rate of 1.4-3

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Section: Discussionmentioning

confidence: 95%

Elemental balances during intravenous hyperalimentation of underweight adult subjects.

Rudman¹,

Millikan²,

Richardson³

et al. 1975

J. Clin. Invest.

198

View full text Add to dashboard Cite

show abstract

“…However, with the exception of individual cases, mortality among these patients was nearly 100% until the 1960s (7). It was not until the advancement of modern medicine, especially due to the achievements of Dudric in the field of parenteral nutrition, that many patients were given the chance to survive and heal (8). Another milestone development occurred in the 1990s when Rotondo presented a new concept in traumatology: damage control surgery.…”

Section: Discussionmentioning

confidence: 99%

The Use Of Negative Pressure Wound Therapy (NPWT) In The Management Of Enteroatmospheric Fistula – Case Report And Literature Review

Jaguścik¹,

Walczak²,

Porzeżyńska³

et al. 2015

Polish Journal of Surgery

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c A S E R E P O R t SAn enteric fistula that occurs in an open abdomen is called an enteroatmospheric fistula (EAF) and is the most challenging complication for a surgical team to deal with. The treatment of EAF requires a multidisciplinary approach. First of all, sepsis has to be managed. Any fluid, electrolyte and metabolic disorders need to be corrected. Oral intake must be stopped and total parenteral nutrition introduced. The control and drainage of the effluent from the fistula is a separate issue. Since there are no fixed algorithms for the treatment of EAF, surgeons need to develop their own, often highly unconventional solutions. We present the case of a 24-year-old man who developed enteroatmospheric fistula after laparotomy and relaparotomy due to acute necrotic pancreatitis. Both the laparostomy and the fistula were successfully managed using modified negative pressure wound therapy. The literature regarding this issue was also reviewed.

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“…Total parenteral alimentation provides such an approach, and its effectiveness in the cure of intractable diarrhea has been documented recently in an increasing number of reports [5,6,10,14,25,28]. Table IV summarizes pub- lished data on 22 infants with protracted diarrhea who were treated by total parenteral alimentation.…”

Section: Discussionmentioning

confidence: 99%

Endogenous Amino Acid Loss and Its Significance in Infantile Diarrhea

1973

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ExtractSignificant amino acid loss through the stool, analogous to impeded reabsorption of water, fat, and electrolytes, was suspected in infantile diarrhea. The stools of six patients, who had acute diarrhea and received no protein by mouth, were collected and analyzed for amino acids, nitrogen, and protein. Similar determinations were made on five normal controls. In addition, stool collections were made from one patient during a severe protracted diarrhea which necessitated parenteral alimentation, during a subsequent isolated acute episode of diarrhea, and after complete recovery. The results of the analyses showed that free amino acids in the stool are elevated up to 10-fold during diarrhea, as compared with periods of remission and with normal controls. Protein and total nitrogen excretion is also elevated in diarrhea, although to a lesser degree (4-and 2.5-fold, respectively). It is postulated that protracted diarrhea is associated with impaired reabsorption of endogenous nitrogen, which results in a vicious cycle of protein depletion that ultimately leads to an intractable stage. The validity of this assumption is confirmed by the success achieved by parenteral amino acid therapy for protracted diarrhea.

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Can Intravenous Feeding as the Sole Means of Nutrition Support Growth in the Child and Restore Weight Loss in an Adult?

Cited by 382 publications

References 3 publications

Elemental balances during intravenous hyperalimentation of underweight adult subjects.

Elemental balances during intravenous hyperalimentation of underweight adult subjects.

The Use Of Negative Pressure Wound Therapy (NPWT) In The Management Of Enteroatmospheric Fistula – Case Report And Literature Review

Endogenous Amino Acid Loss and Its Significance in Infantile Diarrhea

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