Can Intraocular Lenses Deliver Antibiotics Intracamerally?

Abstract

Both lenses were capable of delivering clinically significant antibiotic levels after a 1-min soak. Moxifloxacin concentrations reached at both 1 and 10-min soak times exceed the MIC(90) of the most common pathogens responsible for postoperative endophthalmitis. The antibiotic-soaked IOL has potential to become a clinically significant technique in the prevention of postoperative endophthalmitis.

Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin

“…However, the released MFX concentrations of our best system (discs #4, Fig. 6A) were (i) higher than in a study in which IOLs were loaded by soaking in Vigamox (MFX-containing eye drops, at a concentration of 5 mg/mL) for 10 min (0.7 vs. 0.3 µg/mL of MFX, respectively, after 30 min of release, the only release time studied in the literature study [46]), although our soaking time was much longer and at a higher temperature, and (ii) lower than in a study in which IOLs were soaked in Vigamox for 24 h (20 µg/mL vs. 75 µg/mL, respectively, after 24 h, the longest release time of the literature study [15]), although our soaking time was shorter (15 h) and at a higher temperature (37 ºC).…”

The intraocular lens as a drug delivery device for an epidermal growth factor–Receptor inhibitor for prophylaxis of posterior capsule opacification

“…The principle of pharmacologically modifying IOLs has previously been developed, and IOLs have been proposed for the delivery of antibiotics and anti‐inflammatories in vitro (Shaw et al. ) and in a rabbit model (Kleinmann et al. ).…”

Intraocular lens as a drug delivery reservoir

“…optic size or haptic design), the property, concentration and loading time of the drug, the IOL affinity to the drug and environmental factors (i.e. However, both types of IOLs would be capable of providing clinically significant drug levels [5]. In general, IOLs made of hydrophilic materials, such as hydrophilic acrylic (hydrogel), are capable of absorbing and releasing greater amounts of drug [10,[24][25][26], whereas IOLs made of hydrophobic materials, such as silicon, PMMA or hydrophobic acrylic, have poorer drug uptake and release [24,25].…”