Can Gold Nanoparticles Improve Delivery Performance of Polymeric Drug-Delivery Systems?

Lacroce, Elisa; Saccomandi, Paola; Rossi, Filippo

doi:10.4155/tde-2021-0037

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…AuNP have been investigated as a method for improving the thermal treatments, since they combine their properties of ease of synthesis and biocompatibility [43] with their advantageous electrothermal effects: lowering the impedance of the tissue at the electrode contact point, hence extending the duration of RFA [44], and improving the heating process at the peripheral side of the tumor [45,46], hence targeting a wider region. In addition, AuNP improves the drug delivery systems within cancer tissues, as shown in previous works [27,47,48].…”

Section: Introductionsupporting

confidence: 60%

Fiber-Optic Distributed Sensing Network for Thermal Mapping of Gold Nanoparticles-Mediated Radiofrequency Ablation

et al. 2022

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In this work, we report the design of an optical fiber distributed sensing network for the 2-dimensional (2D) in situ thermal mapping of advanced methods for radiofrequency thermal ablation. The sensing system is based on six high-scattering MgO-doped optical fibers, interleaved by a scattering-level spatial multiplexing approach that allows simultaneous detection of each fiber location, in a 40 × 20 mm grid (7.8 mm2 pixel size). Radiofrequency ablation (RFA) was performed on bovine phantom, using a pristine approach and methods mediated by agarose and gold nanoparticles in order to enhance the ablation properties. The 2D sensors allow the detection of spatiotemporal patterns, evaluating the heating properties and investigating the repeatability. We observe that agarose-based ablation yields the widest ablated area in the best-case scenario, while gold nanoparticles-mediated ablation provides the best trade-off between the ablated area (53.0–65.1 mm2, 61.5 mm2 mean value) and repeatability.

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Section: Introductionsupporting

confidence: 60%

Fiber-Optic Distributed Sensing Network for Thermal Mapping of Gold Nanoparticles-Mediated Radiofrequency Ablation

et al. 2022

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“…Moreover, the small size of gold NPs allows their accumulation in sites of tumor and inflammation and exhibits fast cell uptake using mechanisms different from those typical of small molecules. 4 Nickel (Ni) nanocarriers have been widely used in biomedical applications as antibacterial and anticancer agents. They could increase cell membrane permeability and promote cellular absorption into cancer cells of the outer target molecules.…”

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confidence: 99%

Efficacy of Gold and Nickel on the Anticancer Activity and Physical Properties of Pemetrexed Loaded on Fullerene C60 Buckysomes

Mahdi¹,

Maraie²,

Dawood³

2022

IJDDT

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Objective: This study aims to create a new delivery system for pemetrexed, employing a metal-C60 fullerene combination for the first time. Additionally, a lung cancer cell line study will be used to examine the impact of this combination on the release, behavior, and drug’s cytotoxicity. Methods: To utilize a laser to irradiate hydrocarbons, fullerene C60 (Buckysomes) was produced and then nanosized by adding different volumes of isopropyl alcohol and ultrasonication. Gold Nanoparticles (AuNPs) and nickel nanoparticles (NiNPs) were also prepared each one separately and added to the previous mixture together with Pemetrexed (PMX) with further ultrasonication for 20 minutes. The mixture is kept in the refrigerator for 20 hours and then filtered. The precipitate was dried and characterized for particle size, invitro release, and anticancer activity in comparison to pemetrexed loaded on C60 fullerene previously prepared in our laboratory. Results: The evaluation techniques revealed the successful loading of pemetrexed on metals- fullerene C60 nanocarrier, SG10 was the optimum sample with % of yield reach to 95.36. The release profile shows that the percentage release of pemetrexed after 240 minutes is equal to 40% from pure PMX, while the release after 240 minute was found to be 87.8 % from pemetrexed loaded gold nanoparticles (AuNPs) fullerene C60 nanocarrier (SG10), while NiNPs not significantly improved the release profile of Pemetrexed from Pemetrexed loaded NiNPs – fullerene (SN7). Pemetrexed loaded on gold nanoparticles (AuNPs), when compared to pure PMX (3.1 M) and SN7 (11.5 M), fullerene nanocarrier (SG10) exhibits a lower IC50 (1.55 M) and a greater cytotoxic effect (high IR percent) on A549 cancer cells. Pemetrexed’s cytotoxicity in A549 was enhanced after being loaded onto gold nanoparticles (AuNPs)-fullerene nanocarriers (90.4% cell death for SG10) as opposed to pure drug (60% cell death). This finding suggests that the loading process enhanced the drug’s cytotoxic activity for the tumor cells, which may have sped up the onset of action (30% cell death after 24 hours). Conclusion: This study successfully prepared Metals- fullerene C60 Buckysomes loaded with pemetrexed utilizing gold and nickel, which may serve (especially Au- fullerene) as a suitable nanocarrier for pemetrexed, resulting in an improvement to solubility, the release pattern, and cytotoxicity.

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Can Gold Nanoparticles Improve Delivery Performance of Polymeric Drug-Delivery Systems?

Abstract: In this Editorial the applications of Au NPs and thermo-responsive hydrogels are summarized in order to underline the importance of these hybrid materials in the biomedical field. "

Cited by 2 publications

References 18 publications

Fiber-Optic Distributed Sensing Network for Thermal Mapping of Gold Nanoparticles-Mediated Radiofrequency Ablation

Fiber-Optic Distributed Sensing Network for Thermal Mapping of Gold Nanoparticles-Mediated Radiofrequency Ablation

Efficacy of Gold and Nickel on the Anticancer Activity and Physical Properties of Pemetrexed Loaded on Fullerene C60 Buckysomes

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