Can garlic reduce levels of serum lipids? a controlled clinical study

Jain, Abhilash; Vargas, Roberto; Gotzkowsky, S. Karl; Fg, McMahon

doi:10.1016/0002-9343(93)90216-c

Cited by 184 publications

(83 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In animal experiments, garlic extracts have been shown to lower plasma lipid and cholesterol in rats (Chi, 1982;Mathew et al, 1996), rabbits (Bordia and Verma, 1980) and chickens (Qureshi et al, 1983a,b). Moreover, a number of intervention studies have similarly shown that garlic and garlic preparations significantly reduced plasma lipids, especially total cholesterol and low density lipoprotein (LDL) cholesterol in humans (Jain et al, 1993;Steiner et al, 1996). However, recent studies suggested that not all garlic preparations may be hypocholesterolaemic (Simon et al, 1995;Isaacsohn et al, 1998;McCrindle et al, 1998).…”

mentioning

confidence: 99%

The effects of dietary garlic powder on performance, egg yolk and serum cholesterol concentrations in laying quails

Canoğulları¹,

Baylan²,

Erdoğan³

et al. 2010

Czech J. Anim. Sci.

View full text Add to dashboard Cite

ABSTRACT:This study was conducted to investigate the effects of garlic powder on the performance, egg traits, egg cholesterol and serum parameters of laying Japanese quails. One hundred and twenty 10-weeks-old quails were allocated to four dietary treatments. Quails were caged individually and fed diets supplemented with 0 (control), 1, 2, 4% garlic powder for 12 weeks. There were significant (P < 0.05) differences among the diets in feed consumption, feed efficiency and egg production as averaged over 12 weeks. The better values for these parameters were obtained from the 1% garlic powder supplemented group. Garlic powder addition did not significantly affect egg yolk index, egg shell weight and egg shell thickness. However, there were significant differences (P < 0.05) in egg albumen index, egg shell index and Haugh unit. There was a significant (P < 0.05) reduction in the egg yolk cholesterol concentration when the dietary level of garlic powder was increased from 0 to 4 g/kg. Plasma high density lipoprotein (HDL) cholesterol concentrations increased (P < 0.05) with increasing levels of dietary garlic powder. Plasma cholesterol (P < 0.05) and triglyceride (P < 0.05) concentration decreased with garlic powder supplementation. It was concluded that garlic powder in the diet of laying quails reduced the plasma and egg yolk cholesterol concentration.

show abstract

mentioning

confidence: 99%

The effects of dietary garlic powder on performance, egg yolk and serum cholesterol concentrations in laying quails

Canoğulları¹,

Baylan²,

Erdoğan³

et al. 2010

Czech J. Anim. Sci.

View full text Add to dashboard Cite

show abstract

“…In the present study there was non-significant reduction in blood glucose in garlic extrac. The prior reports [15,16] showed that garlic had not influence on the concentration of serum glucose.…”

Section: Discussionmentioning

confidence: 99%

Effect of garlic (Allium sativum) on lipid profiles, antioxidant activity and expression of scavenger receptor class B type I (SR-BI) in liver and intestine of hypercholesterolemic mice

Mohammadi

Norouzian

Jamshidi

et al. 2009

JAC

View full text Add to dashboard Cite

Garlic is one of the medicinal plants, which has shown many useful effects, including Antioxidant activity, hypolipidemic and hypocholesterolemic effects, anti-hypertensive and anti-diabetic effects. Scavenger receptor class B type I (SR-BI) is a cell-surface receptor which mediated selective cholesterol ester uptake from the HDL particle. SR-BI also has an important role in cholesterol absorption in the intestine. Animals were randomly divided into three groups (n=8); group 1: received chow + cholesterol (2%) + cholic acid (0.5%), group 2: chow + 4% (w/w) garlic extract + cholesterol (2%) + cholic acid (0.5%), and group 3: chow only. After one-month mice were sacrificed, blood was collected; lipid profile and blood glucose were determined enzymatically as well as mRNA and protein levels of SR-BI were determined by RT-PCR and westernblot respectively. Compared with hypercholesterolemic control, garlic extract significantly decreased total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, Very Low-Density Lipoprotein-Cholesterol (VLDL-C) and atherogenic index (all of them P<0.05). The activity of Super oxide dismutase(SOD), glutathione (GSH) and catalase levels were markedly increased in garlic-treated animals compared with hypercholesterolemic animals (p<0.05). The plasma levels of MDA markedly reduced in garlic group compared with hypercholesterolemic group. Intestinal SR-BI mRNA and protein were significantly decreased in garlic extract mice treatment compared with hypercholesterolemic control. Levels of liver SR-BI protein significantly reduced in hypercholesterolemic group (P<0.05).In conclusion, garlic extract markedly reduced TC, LDL-C, TG, VLDL-C and atherogenic index, as compared with the hypercholesterolemic control group. On the other hand garlic extract led to down-regulation of SR-BI protein and mRNA in the intestine of mice.

show abstract

“…This perhaps supports the ability of garlic to reduce LDL cholesterol concentration. Evidence from available studies showed that garlic can affect vasculature by improving aortic elasticity as well as retardation of atherosclerosis progression [6][7][8][9]15,16,18 perhaps through increase excretion of LDL-cholesterol.…”

Section: Discussionmentioning

confidence: 99%

“…Available report has shown that it could be used for any ailments such as parasitic infections, respiratory problems, poor digestion and low energy 5 . Recent studies have reported the ability of garlic to reduce plasma cholesterol in humans [5][6][7] . Evidence on the role of garlic in lowering plasma cholesterol in developed populations abounds 6&8 .…”

Section: Introductionmentioning

confidence: 99%

The effect of garl ic on plasma l ipids and lipoproteins in rats fed on high cholesterol enriched diet

Ebesunun¹,

Popoola²,

Agbedana³

et al. 2010

Biokemistri

View full text Add to dashboard Cite

Garlic has been repo rte d in so me popu lation s to possess h yp olipde mic effec t in particu lar on lo w den sity lipoprote in cho leste rol, thu s pre venting card io va scula r d ise ase risk. Sixteen ma le a lbino ra ts of se ven we eks o ld were pu rcha sed fo r th is stud y. The se we re divided in to four grou ps of fou r p er group. Group A wa s fed on a high cho leste rol diet and garlic, g roup B wa s fed on h igh cho leste rol d iet onl y, group C was fed on no rma l d ie t (contro ls) and gro up D was fed on norma l die t and ga rlic. The p la sma lip id s, lipop ro tein s and tissu es h istologic a l appea rance s we re de termined using sta ndard procedu res. Re sults showed sign ifican t dec reased in the mean we t tissue weig ht of the kid ne y (p<0.001 ) in the group fed on high Choleste ro l+garlic d ie t. The plasma LD LC was markedly redu ced in th e groups fed o n high ch oleste rol die t + ga rlic as well a s no rma l d iet+garlic. The mean plasma HD LC a lthou gh not sta tistica lly sign ifican t wa s h ighe r in these groups. Histo log ica l finding s showed pronou nced ath e ro ma tous chan ges in th e coronary a rte ry of rats fed on high cho lestero l d ie t. The consumption of raw garlic has beneficial effect on plasma total cholesterol, and LDLC in rats fed on high cholesterol diet.

show abstract

Can garlic reduce levels of serum lipids? a controlled clinical study

Cited by 184 publications

References 10 publications

The effects of dietary garlic powder on performance, egg yolk and serum cholesterol concentrations in laying quails

The effects of dietary garlic powder on performance, egg yolk and serum cholesterol concentrations in laying quails

Effect of garlic (Allium sativum) on lipid profiles, antioxidant activity and expression of scavenger receptor class B type I (SR-BI) in liver and intestine of hypercholesterolemic mice

The effect of garl ic on plasma l ipids and lipoproteins in rats fed on high cholesterol enriched diet

Contact Info

Product

Resources

About