Can exercise prevent the age‐related decline in adaptive homeostasis? Evidence across organisms and tissues

Hamilton, Karyn L.; Selman, Colin

doi:10.1113/jp284583

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Diets rich in natural antioxidant sources, such as fruits, vegetables, soy, fish, and nuts, are essential for health promotion and disease prevention. The focus on natural food sources for antioxidants supports broader dietary guidelines aimed at improving the overall wellbeing of the general population [81][82][83].…”

Section: Discussion Of the Physiological Implications Of The Findings...mentioning

confidence: 99%

The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks

Meng,

2024

Preprint

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This general review assesses the impact of physical exercise on oxidative and nitrosative stress and the counteractive role of antioxidants, drawing from a systematic literature search up to March 2024 in databases like PubMed and Web of Science. The review highlights studies on the effect of exercise on the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and antioxidant responses in both human and animal models based on rigorous inclusion and exclusion criteria. Due to the variety of exercise types and participants' characteristics, a narrative synthesis approach was adopted. The findings indicate that moderate exercise boosts antioxidant defenses, known as hormesis, whereas excessive physical activity may increase oxidative and nitrosative damage. The review also explores the complex effects of antioxidant supplementation, revealing that while natural dietary antioxidants support health, high-dose supplements could potentially hinder positive adaptations to exercise. Recommendations for athletes and the general active population highlight the importance of balancing exercise and dietary intake to optimize health benefits. The review concludes with a call for more detailed research on tailored exercise and nutrition plans to dissect these intricate relationships further.

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Section: Discussion Of the Physiological Implications Of The Findings...mentioning

confidence: 99%

The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks

Meng,

2024

Preprint

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“…Understanding how demographic factors such as age, gender, health status, ethnicity, and socioeconomic background influence oxidative and nitrosative stress responses to exercise is crucial for developing personalized health and fitness programs [80][81][82][83][84]. Older adults, who naturally experience declines in antioxidant production and mitochondrial function, may benefit from moderate-intensity exercises combined with antioxidant-rich diets to counteract age-related oxidative stress [85].…”

Section: Demographic Variability In Oxidative Stress Responsementioning

confidence: 99%

The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks

Meng,

2024

Antioxidants

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This review comprehensively evaluates the effects of physical exercise on oxidative and nitrosative stress, mainly focusing on the role of antioxidants. Using a narrative synthesis approach, data from empirical studies, reviews, systematic reviews, and meta-analyses published between 2004 and 2024 were collated from databases like PubMed, EBSCO (EDS), and Google Scholar, culminating in the inclusion of 41 studies. The quality of these studies was rigorously assessed to ensure the clarity of objectives, coherence in arguments, comprehensive literature coverage, and depth of critical analysis. Findings revealed that moderate exercise enhances antioxidant defenses through hormesis, while excessive exercise may exacerbate oxidative stress. The review also highlights that while natural dietary antioxidants are beneficial, high-dose supplements could impede the positive adaptations to exercise. In conclusion, the review calls for more focused research on tailored exercise and nutrition plans to further understand these complex interactions and optimize the health outcomes for athletes and the general population.

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Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms

Sánchez Milán,

Mulet,

Serra

et al. 2024

Aging

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Increased oxidative stress (OS) and the disruption of the equilibrium between the production of reactive oxygen species and antioxidants are key molecular features of unhealthy aging. OS results in the formation of oxidative posttranslational modifications (PTMs), some of which involve cysteine (Cys) residues in aging proteomes, and specifically, the formation of trioxidized Cys (t-Cys), which leads to permanent protein damage. Recent findings in rodents have uncovered that irregular regulation of t-Cys residues in the aging proteome disrupts homeostatic phosphorylation signaling, resulting in alterations to proteins that are analogous to those caused by phosphorylated serine (p-Ser) residues. This work contextualizes these significant findings and discusses the implications and molecular role(s) of t-Cys in the aging proteome. Furthermore, we present novel data, validating the increase of specific t-Cys sites associated with aging in a blood-related circulating human proteome. The scope and findings included here support the hypothesis that t-Cys residues may serve as important mechanistic and biological markers, warranting further exploration in the context of unhealthy aging and age-related major diseases.

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Can exercise prevent the age‐related decline in adaptive homeostasis? Evidence across organisms and tissues

Cited by 3 publications

References 21 publications

The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks

The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks

The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks

Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms

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