Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms
José Antonio Sánchez Milán,
María Mulet,
Aida Serra
et al.
Abstract:Increased oxidative stress (OS) and the disruption of the equilibrium between the production of reactive oxygen species and antioxidants are key molecular features of unhealthy aging. OS results in the formation of oxidative posttranslational modifications (PTMs), some of which involve cysteine (Cys) residues in aging proteomes, and specifically, the formation of trioxidized Cys (t-Cys), which leads to permanent protein damage. Recent findings in rodents have uncovered that irregular regulation of t-Cys residu… Show more
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