Can dietary zinc diminish the impact of necrotic enteritis on growth performance of broiler chickens by modulating the intestinal immune-system and microbiota?

Bortoluzzi, Cristiano; Vieira, Bruno Serpa; Lumpkins, Brett; Mathis, Greg F.; King, W. D.; Graugnard, Daniel E.; Dawson, K. A.; Applegate, T. J.

doi:10.3382/ps/pez045

Cited by 24 publications

(14 citation statements)

References 40 publications

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“…In a recent study, a Zn amino acid complex added to a wheat–rye based diet (at 60 mg/kg Zn) of broiler chickens increased Zn digestibility and villus length:crypt depth ratio, reduced abundance of some genera within the Proteobacteria phylum and oxidative stress, and improved starter phase feed conversion ratio compared to an equivalent amount of dietary Zn from Zn sulphate [ 35 ]. Additionally, in a necrotic enteritis broiler chicken challenge model, dietary Zn supplementation (90 mg/kg Zn) reduced NE lesions and mortality, as well as jejunal toll-like receptor 2 and ZnT5 expression [ 36 ]. Specifically, Zn proteinate reduced ileal Lactobacillus and counteracted jejunal upregulation of IL-8 and interferon-γ due to the challenge, and downregulated inducible nitric oxide synthase, in comparison to birds receiving the same amount of Zn from ZnSO 4 , indicative of attenuated jejunal inflammation.…”

Section: Zinc Copper and Manganese Influences On Intestinal Healthmentioning

confidence: 99%

Recent Advances in Understanding the Influence of Zinc, Copper, and Manganese on the Gastrointestinal Environment of Pigs and Poultry

Broom

Monteiro²,

Piñon³

2021

Animals

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Zinc, copper, and manganese are prominent essential trace (or micro) minerals, being required in small, but adequate, amounts by pigs and poultry for normal biological functioning. Feed is a source of trace minerals for pigs and poultry but variable bioavailability in typical feed ingredients means that supplementation with low-cost oxides and sulphates has become common practice. Such trace mineral supplementation often provides significant ‘safety margins’, while copper and zinc have been supplemented at supra-nutritional (or pharmacological) levels to improve health and/or growth performance. Regulatory mechanisms ensure that much of this oversupply is excreted by the host into the environment, which can be toxic to plants and microorganisms or promote antimicrobial resistance in microbes, and thus supplying trace minerals more precisely to pigs and poultry is necessary. The gastrointestinal tract is thus central to the maintenance of trace mineral homeostasis and the provision of supra-nutritional or pharmacological levels is associated with modification of the gut environment, such as the microbiome. This review, therefore, considers recent advances in understanding the influence of zinc, copper, and manganese on the gastrointestinal environment of pigs and poultry, including more novel, alternative sources seeking to maintain supra-nutritional benefits with minimal environmental impact.

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Section: Zinc Copper and Manganese Influences On Intestinal Healthmentioning

confidence: 99%

Recent Advances in Understanding the Influence of Zinc, Copper, and Manganese on the Gastrointestinal Environment of Pigs and Poultry

Broom

Monteiro²,

Piñon³

2021

Animals

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“…A reusable metal oral gavage needle together with the regular disposable syringe (3–5 mL in volume size) works effectively in broiler research ( Bortoluzzi et al., 2019a and 2019b ). As the gavage needle/tube could fall off because of bird movement, it is essential to use a syringe with a luer-lock.…”

Section: Oral Gavagementioning

confidence: 99%

“…The speed and amount of blood collection and final collected amount may vary depending on the proficiency of the personnel. It is recommended to store the blood collection tube immediately in a dark-colored container and keep at room temperature for 2 to 3 h until all samples are well clotted ( Bortoluzzi et al., 2019a and 2019b ; Teng et al., 2020 ). Centrifuging blood samples from broiler chickens can be set at 500 to 2,000 g for 10 to 15 min at 4°C ( Tellez et al., 2014 ; Vicuña et al., 2015a ; Zhang et al., 2016 ; Gilani et al., 2018a ; Baxter et al., 2019 ).…”

Section: Blood Collectionmentioning

confidence: 99%

“…Enough additional FITC-d solution should be reserved for making a standard curve. Triplicate wells are recommended for running each standard curve concentration, while duplicate wells are good for serum sample measurement ( Bortoluzzi et al., 2019a and 2019b ). The flat bottom black opaque plate (minimize back-scattered light, background and crosstalk of fluorescence when reading the plate) is used for measuring FITC-d product.…”

Section: Fitc-d Analysismentioning

confidence: 99%

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Assay considerations for fluorescein isothiocyanate-dextran (FITC-d): an indicator of intestinal permeability in broiler chickens

et al. 2021

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Fluorescein isothiocyanate-dextran ( FITC-d ) is being used as an indicator of intestinal paracellular permeability in poultry research. Especially with the industry moving toward antibiotic-free production, intestinal function and integrity issues have been a research focus. An increasing number of scientific conference abstracts and peer-reviewed journal publications have shown that 4-kDa FITC-d is an efficient marker candidate for measurement of intestinal permeability and can be applied in broiler research. However, experimental protocols vary by personnel, instruments used, and research institution, and potential concerns related to this assay have yet to receive the same amount of attention. Understanding protocol consistency within and across laboratories is vital for obtaining accurate, consistent, and comparable experimental results. This review is aimed to 1) summarize different FITC-d assays in broiler research from peer-reviewed publications during the past 6 yr and 2) discuss factors that can potentially affect intestinal permeability results when conducting the FITC-d assay. In summary, it is essential to pay attention to details, including gavage dose, fasting period, sample handling and lab analysis details when conducting the assay in broiler research. Differences in birds (breed/strain, age, and gender) and experimental design (diet, health status/challenge model, and sampling age) need to be considered when comparing serum FITC-d concentration results between different in vivo animal trials.

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“…In addition to its role in improving egg production, such as quality, thickness of the shell, increase in egg weight, higher hatchability, and improvement in leg skin in laying hens (Maciel et al, 2010). Organic zinc, when added to poultry diets, improves intestinal walls, increases villi length, and thus increases absorption (Bortoluzzi et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Effect of Diet Supplementation With Mixtures of Organic Trace Minerals on Productive Performance of Broiler Chicks

Mohsen¹,

Al-Mahdawi²

2021

PLANT ARCHIVES

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The present study was at the poultry field department of Animal recourse -College of Agriculture Engineering Science University of Baghdad from the period 12/10/2019 to 23/11/2019 determine the study effect add mixture of Organic Trace Minerals(OTM) and the mixture between them and in different proportions to the broiler diets on productive performance ,carcass characteristics and immunological responses and some physiological traits .Three hundred (300) unsexed of broiler chicks breed of 41.30g (Ross 308) One day age were use in the study .the birds distributed to five treatment with three replications per treatment (60 bird /treatment) as follows : T1 supplemented with (Zn 40 + Fe 30) mg/kg diet respectively, T2 supplemented with (Zn 40 + Mn 40 + Cu 7) mg/kg diet respectively, T3 supplemented with (Zn 40 + Se 0.3) mg/kg diet respectively, T4 supplemented with (Zn 40 + Cr 0.4) mg/kg diet respectively, T5 control (without addition). Were fed on starter diet from age 1-21 day, the starter diet consists of (23 % protein and 3003 Kcal metabolic energy /kg diet ) and finisher diet from 22-42 day consists of (20 % protein and 3201 Kcal metabolic energy /kg diet). The results of the present study following: 1-Significant improvement (P<0.05) in the average of body weight and body weight gain for T4 compared with control group. 2-No significant improvement average feed intake weekly, while it was significant (P<0.05) feed intake consumption for T4, and no significant improvement in feed conversion.

show abstract

Can dietary zinc diminish the impact of necrotic enteritis on growth performance of broiler chickens by modulating the intestinal immune-system and microbiota?

Cited by 24 publications

References 40 publications

Recent Advances in Understanding the Influence of Zinc, Copper, and Manganese on the Gastrointestinal Environment of Pigs and Poultry

Recent Advances in Understanding the Influence of Zinc, Copper, and Manganese on the Gastrointestinal Environment of Pigs and Poultry

Assay considerations for fluorescein isothiocyanate-dextran (FITC-d): an indicator of intestinal permeability in broiler chickens

Effect of Diet Supplementation With Mixtures of Organic Trace Minerals on Productive Performance of Broiler Chicks

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