Can dietary factors influence prostatic disease?

Morton,; Turkes,; Denis, Denis; Griffiths,

doi:10.1046/j.1464-410x.1999.00270.x

Cited by 20 publications

(7 citation statements)

References 39 publications

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“…Similar methods were used to chronicle ejaculate collection and to analyze the lignan content of seminal fluid [34,35]. As with urine, converted plant-lignans are expressed in the seminal fluid, and findings of Morton et al suggest a reduced risk of PC not only among men, who consume higher amounts of dietary lignans, but who also express higher concentrations of lignans in their seminal fluid [11,34].…”

Section: Baseline Appointment and Measuresmentioning

confidence: 99%

“…Our exploration of the potential benefits of dietary manipulation began with an incident case of a patient with high grade prostatic intraepithelial neoplasia (HGPIN) who demonstrated remarkable reductions in PSA and notable cellular atrophy upon repeat biopsy after adhering to a flaxseedsupplemented, low-fat diet. Given that flaxseed is an exceptionally rich source of both dietary lignans and omega-3 fatty acids, dietary factors that have been found to influence androgen and COX-2 metabolism (the effects on the COX-2 pathway may be further enhanced by a low-fat diet which may accelerate the conversion of alpha-linolenic acid [ALA : 18 : 3n-3] to longer chained and more physiologically active omega-3 fatty acids, eicosapentanoic [EPA : 20 : 5n-3] and docosahexanoic [DHA : 22 : 5n-3] acids) [8][9][10][11][12][13][14], we followed-up this observation with three studies: (1) an in vitro experiment that exposed three major PC cell lines (LNCaP, DU-145, and PC-3) to flaxseed-derived mammalian lignans [15]; (2) an animal feeding experiment that tested a 5% flaxseed-supplemented diet against an isocaloric-controlled diet in transgenic mice genetically programmed to develop PC [16]; and (3) a pilot feasibility study of a low-fat, flaxseed-supplemented diet in men found to have HGPIN or atypia [17]. In all of these studies, flaxseed derived lignans, flaxseed itself or the flaxseed diet with concomitant dietary fat restriction were found to significantly hinder prostatic growth (via decreased proliferation and increased apoptosis in both malignant and benign tissue), and/or reduce tumor burden.…”

Section: Introductionmentioning

confidence: 99%

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Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancer

et al. 2008

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BackgroundThe time between the diagnosis of cancer and a planned definitive surgical procedure offers a strong and direct approach for assessing the impact of interventions (including lifestyle interventions) on the biology of the target tissue and the tumor. Despite the many strengths of presurgical models, there are practical issues and challenges that arise when using this approach.Purpose/MethodsWe recently completed an NIH-funded phase II trial that utilized a presurgical model in testing the comparative effects of flaxseed supplementation and/or dietary fat restriction on the biology and biomarkers associated with prostatic carcinoma. Herein, we report the rationale for our original design, discuss modifications in strategy, and relay experiences in implementing this trial related to the following topics: (1) subject accrual; (2) subject retention; (3) intervention delivery; and (4) retrieval and completion rates regarding the collection of paraffin-embedded and fresh frozen prostate tissue, blood, urine, ejaculate, anthropometric measures and survey data.ResultsThis trial achieved its accrual target, i.e., a racially-representative (70% white, 30% minority) sample of 161 participants, low rates of attrition (7%); and collection rates that exceeded 90% for almost all biospecimens and survey data. While the experience gained from pilot studies was invaluable in designing this trial, the complexity introduced by the collection of several biospecimens, inclusion of a team of pathologists (to provide validated readings), and shifts in practice patterns related to prostatectomy, made it necessary to revise our protocol; lessons from our experiences are offered within this article.ConclusionsWhile our experience specifically relates to the implementation of a presurgical model-based trial in prostate cancer aimed at testing flaxseed-supplemented and fat-restricted diets, many of the lessons learned have broad application to trials that utilize a presurgical model or dietary modification within various cancer populations.

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Section: Baseline Appointment and Measuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancer

et al. 2008

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“…Dietary estrogens found in foods such as legume s and soya have been considered possible protective agent s in the diet of Asian men, who have a lower incidence of prostate disease (Morton et al 1999). Dietary estrogens found in foods such as legume s and soya have been considered possible protective agent s in the diet of Asian men, who have a lower incidence of prostate disease (Morton et al 1999).…”

Section: Dietary Estrogens and The Prostate Phenotypementioning

confidence: 99%

New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

Korach¹,

Hillisch²,

Fritzemeier³

2004

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© Springer-Verlag Berlin Heidelberg 2004 Originally published by Springer-VerlagBerlin Heidelberg in 2004. Softcover reprint of the hardcover 1st edition 2004The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability : The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: K+ V Fotosatz GmbH, BeerfeldenCover Design: design & production, Heidelberg 21/3150/AG-5 4 3 2 I 0 -Printed on acid-free paper Preface From our current knowledge, it is obvious that estrogen action involves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointestinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the spectrum of significant physiological dysfunctions that occur when there is a lossThe participants of the workshop VI Preface of the hormone or the receptor activity. Loss of estrogen, however (for instance during menopause) , occurs with time and results in a variety of clinical conditions. We know that the developmental loss of estrogen, as seen in clinical cases of aromatase gene mutations and experimental models, has dramatic effects in both men and women alike. The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient.Developing an understanding of the spectrum of estrogen in a variety of tissues related to the condition of estrogen loss is a major and highly active clinical as well as basic scientific research area. Following the discovery of a second estrogen receptor and possible receptor ligand-independent activity as well as the genomic and nongenomic actions of estrogen, it is clear that the mechanisms of the effects of estrogen are multifaceted .Based on these possible mechanisms, understanding the effects of estrogen in different organ systems and specific target cells is an essential part of this area of research, for which a scarcity of information currently exists. Thus, a goal of this workshop and its proceedings was to provide a discussion forum for presentation of current cutting-edge developments in the experimental approaches and applications of estrogen research studies for determining a more complete appreciation of the physiological actions, genomic and non-genomic responses and the cellular mechanisms involved in estrogen hormone action. Such information is essential for the develop...

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“…In mehreren Studien aus Griechenland und Spanien korrelierte eine Erhöhung des Olivenölanteils an der Nahrung signifikant mit einem niedrigeren Erkrankungsrisiko für hormonabhängige Malignome (28,45). Neben den Vitaminen A, C und E sowie Selen zeichnen sich eine ganze Reihe von sekundären Pflanzenstoffen (zum Beispiel Karotinoide und Flavonoide) durch eine ausgeprägte antioxidative Wirkung aus, die diejenige der genannten Vitamine häufig um ein mehrfaches übertrifft (30). Eine der aussagekräftigsten Untersuchungen zu dem Thema SPS stammt aus Japan.…”

Section: Dietary Prevention Of Carcinomas Of the Breast And Prostate: Fundamental And Practical Aspects Of The Nutritional Cancer Preventunclassified

Diätetische Prävention des Mamma- und Prostatakarzinoms: Grundlagen und Praxis des Nutritional Cancer Prevention (NCP)-Programms

Ebert

Kleine-Gunk

Altwein

et al. 2002

Dtsch med Wochenschr

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Can dietary factors influence prostatic disease?

Cited by 20 publications

References 39 publications

Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancer

Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancer

New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

Diätetische Prävention des Mamma- und Prostatakarzinoms: Grundlagen und Praxis des Nutritional Cancer Prevention (NCP)-Programms

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