Can d-dimer become a new diagnostic parameter for acute appendicitis?

Menteş, Öner; Eryılmaz, Mehmet; Harlak, Ali; Özer, Tahir; Balkan, Müjdat; Kozak, Orhan; Tufan, Turgut

doi:10.1016/j.ajem.2008.06.001

Cited by 12 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the sensitivity of D-dimer was estimated to be 29 % in our study. Mentes O et al 27 have reported the similar results for the diagnostic value of D-dimer. We found that specificity of D-dimer test in acute appendicitis was relatively higher (about 75%).…”

Section: Discussionsupporting

confidence: 57%

The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis

Kaya¹,

Sana²,

Eris³

et al. 2012

Int. J. Med. Sci.

View full text Add to dashboard Cite

BACKGROUND: The early diagnosis of acute abdomen is of great importance. To date, several inflammatory markers have been used for the diagnosis of acute abdominal conditions, including acute appendicitis. The aim of this study was to evaluate the diagnostic utility of D-dimer, Procalcitonin (PCT) and C-reactive protein (CRP) measurements in the acute appendicitis.METHODS: This prospective study was conducted between March 1st, 2010 and July 1st, 2011. In this period, seventy-eight patients were operated with the diagnosis of acute appendicitis, and D-dimer, PCT and CRP levels of the patients were measured. The patients were grouped as phlegmonous appendicitis (Group 1), gangrenous appendicitis (Group 2), perforated appendicitis (Group 3) and negative appendectomy (Group 4) according to the surgical findings and histopathological results.RESULTS: Of 78 patients, 54 (69.2 %) were male and 24 (30.8 %) were female, and the mean age was 25.4 ± 11.1 years (range, 18 to 69 years). 66 (84.6 %) patients had increased leukocyte count (white blood cell count). The PCT values were higher than the upper normal limit in 20 (25.6%) patients, followed by D-dimer in 22 (28.2 %) patients and CRP in 54 (69.2 %) patients. The diagnostic value of leukocyte count and CRP in acute appendicitis was higher than that of the other markers, whereas leukocyte count showed very low specificity. CRP values were higher in perforated appendicitis when compared with the phlegmonous appendicitis (p<0.05). However, PCT and D-dimer showed lower diagnostic values (26% and 31%, respectively).CONCLUSION: An increase in CRP levels alone is not sufficient to make the diagnosis of acute appendicitis. However, CRP levels may differentiate between phlegmonous appendicitis and perforated appendicitis. Due to their low sensitivity and diagnostic value, PCT and D-dimer are not better markers than CRP for the diagnosis of acute appendicitis.

show abstract

Section: Discussionsupporting

confidence: 57%

The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis

Kaya¹,

Sana²,

Eris³

et al. 2012

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Several diagnostic tests are used for appendicitis including leucocyte count, neutrophil percentage, C-reactive protein (CRP), D-Dimer, and Procalcitonin. [3][4][5][6] However, today, there is no single laboratory test or imaging modality for diagnosing acute appendicitis with 100% sensitivity.…”

Section: Discussionmentioning

confidence: 99%

The clinical value of leucocyte count and neutrophil percentage in diagnosing uncomplicated (simple) appendicitis and predicting complicated appendicitis

Şahbaz¹,

Bat²,

Kaya³

et al. 2014

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

show abstract

“…A combination of physical examination, certain laboratory tests and a number of imaging studies are used for definitive diagnosis. There are several diagnostic tests which are used for appendicitis, including leukocyte count, percentage of neutrophils, C-reactive protein (CRP), procalcitonin and D-Dimer (18)(19)(20) .…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Neutrophil/Lymphocyte Ratios in the Diagnosis of Acute Appendicitis

Akyüz¹,

Topal²,

Gök³

et al. 2020

BMJ

View full text Add to dashboard Cite

Objective: The debate on the value of laboratory tests in the diagnosis of acute appendicitis (AA) continues. In this study, we aimed to evaluate the blood count parameters and the diagnostic value of neutrophil/lymphocyte ratio in the diagnosis of acute appendicitis. Method: 851 patients who underwent appendectomy under emergency conditions were included in the study. Patients were divided into 2 groups; Group 1 was negative appendectomy and Group 2 was acute appendicitis. In addition, they were divided into subgroups as 18-39 years, 40-59 years, and 60 years and older. Neutrophil, platelet, lymphocyte count and Neutrophil/lymphocyte ratio were compared in groups and subgroups. Results: There were 146 patients (17.1%) in Group 1 (negative appendectomy group) and 705 patients (82.9%) in Group 2 (acute appendicitis group). Male sex was dominant in Group 2 (p=0.049). Neutrophil count and neutrophil / lymphocyte ratio (NLR) were higher in Group 2 (p<0.001, p<0.001, respectively), whereas in Group 1, lymphocyte count and platelet count were higher (p=0.008, p=0.002, respectively). The cutoff value for NLR was found to be 5.29 in the ROC curve analysis.

show abstract

Can d-dimer become a new diagnostic parameter for acute appendicitis?

Cited by 12 publications

References 14 publications

The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis

The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis

The clinical value of leucocyte count and neutrophil percentage in diagnosing uncomplicated (simple) appendicitis and predicting complicated appendicitis

Predictive Value of Neutrophil/Lymphocyte Ratios in the Diagnosis of Acute Appendicitis

Contact Info

Product

Resources

About