The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis

Kaya, Bülent; Sana, Barış; Eris, Cengiz; Karabulut, Koray; Bat, Orhan; Kutaniş, Rıza

doi:10.7150/ijms.4733

Cited by 65 publications

(61 citation statements)

References 25 publications

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“…This implicates an important role of vWF in thrombosis associated with disorders such as HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), anti-phospholipid syndrome, and sepsis [15]. D-dimer is a degradation product of fibrin dissolution, usually used in the diagnosis of venous thromboembolism and pulmonary embolism [16]. D-dimer level increases gradually with increasing severity of peripheral vascular sclerosis [17].…”

Section: Discussionmentioning

confidence: 99%

Systemic and Flap Inflammatory Response Associates with Thrombosis in Flap Venous Crisis

Wu²,

Qing³

et al. 2014

Inflammation

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Venous crisis represents the most common complication in flap surgery and often results in flap failure. The gold standard for free flap monitoring is frequent clinical examination. The current study examined the systemic inflammatory response during the immediate post-operative period following flap venous crisis. Superficial epigastric artery perforator flap transplantation was performed in a total of 30 rabbits. Fifteen animals received venous obstruction by vein ligation (venous crisis group, n = 15) and others were sham treated (control group, n = 15). Venous thrombosis was examined by immunohistochemistry staining. Plasma levels of inflammatory response markers (IL-6, IL-8, TNF-α, and C-reactive protein) and thrombosis biomarkers (von Willebrand factor and tissue factor) were measured at 0, 2, and 4 h post-operation by enzyme-linked immunosorbent assay. The mRNA levels of relevant biomarkers in the flap were analyzed with quantitative real-time PCR. Flap histopathological examination showed erythrocyte and neutrophil aggregations in venous lumen and erythrocyte diapedesis. At 8 h post-operation, serious edema and fibrinoid necrosis were observed and the venous lumen was almost blocked by thrombus. The venous crisis group had higher plasma levels of IL-8, TNF-α, and thrombosis biomarkers. Vein ligation also increased the mRNA levels of IL-8, TNF-α, C-reactive protein, von Willebrand factor, and tissue factor in the flap. No significant change in IL-6 levels was observed between the control group and the venous crisis group. Flap venous crisis was accompanied by the increase in a number of inflammatory and thrombosis markers, both in the peripheral blood and the flaps.

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Section: Discussionmentioning

confidence: 99%

Systemic and Flap Inflammatory Response Associates with Thrombosis in Flap Venous Crisis

Wu²,

Qing³

et al. 2014

Inflammation

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“…Görüntüleme yöntemlerinin dışında son yıllarda akut apandisit tanısının öngörüsünde skorlama sistemlerinin yanında ortalama platelet hacmi, D-dimer, C-reaktif protein ve prokalsitonin gibi belirleyicilerle ilgili çalışmaların sayısı artmaktadır (10)(11)(12). Ancak; bu öngörü faktörleri günlük klinik uygulamalarında henüz yer bulamamıştır.…”

Section: Discussionunclassified

The Efficacy of Abdominal Ultrasonographic Examination in Preventing Negative Appendectomies

Akkapulu¹,

Kiymazaslan²,

Düzkalır³

et al. 2013

JAEM

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Objective: Appendectomy is the most commonly performed emergent intervention in general surgery clinics; imaging techniques must be used as a guide to reduce the rate of negative exploration. The aim of this study was to investigate the impact of preoperatively performed abdominal ultrasonographic evaluation on the rate of negative exploration. Material and Methods: Two hundred and fifty nine out of 352 patients who were operated on for acute appendicitis between 1 st January 2011 and 8 th January 2012 at our centre were included in this study. Demographic data, ultrasonographic findings and pathological reports of each patient were evaluated retrospectively. Results:The patients were divided into two groups depending on whether ultrasonographic examination was performed or not. The overall negative exploration rate was 18.5% in patients included in the study; the rate was 18.7% and 18.2% in patients who underwent ultrasonographic examination or not, respectively. However, the difference between the two groups was not statistically significant. Conclusion: Our negative exploration rate was similar to results published in the literature. Ultrasonographic examination performed at our centre has been found to have no impact on reducing negative exploration rates for acute appendicitis. This may be due to the limitations of ultrasonography, which is an operator-dependent technique. Also, this may be the result of anxiety in surgeons; they may be ordering ultrasonography unnecessarily, because of concern over malpractice laws. (JAEM 2013; 12: 118-21

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“…Ülkemizden Kaya ve ark. [23] akut apandisitli hastalarda CRP, prokalsitonin ve D-dimer düzeylerini prospektif olarak değerlendirdikleri çalışmalarında, CRP'nin tanıda tek başına yeterli olmadığını, ancak flegmonöz apandisit ve perfore apandisit için uyarıcı olabileceğini; D-dimer ve prokalsitoninin de CRP'den daha iyi bir belirteç olmadığını vurgulamaktadırlar. Okus ve ark.…”

Section: Tanı Testleriunclassified

Recommendations for Intra-abdominal Infections “Consensus Report”

Avkan-Oğuz¹,

Baykam²,

Sökmen³

et al. 2018

mjima

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Rehberler, konu ile ilgili farklı uzmanlık alanlarından uzmanların her ülkenin kendi verilerini dikkate alarak hazırladıkları önerileri içerir. Ancak ülkemizde bugüne kadar intra-abdominal enfeksiyonlar (İAE) için ortak dil oluşturmak adına, önerileri kapsayan bir rehber kullanıma sunulmamıştır. Bunun en önemli nedeni klinikte İAE'lerin tanı ve tedavisi ile ilgili veya İAE tanılı hastalardan elde edilen mikroorganizma duyarlılıklarını değerlendiren laboratuvar çalışmalarının oldukça az sayıda olmasıdır. Oysa günümüzde farklılaşan konak özellikleri ve gelişen teknolojik tedavi yöntemleri nedeniyle "ortak dil kullanmak" zorunluluk haline gelmiştir. Bu amaçla Mayıs 2015'te; Türkiye Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Uzmanlık Derneği'nin (Türkiye EKMUD) önderliğinde Türk Cerrahi Derneği, Türk Kolon ve Rektum Cerrahisi Derneği, Fıtık Derneği, Türk Hepato Pankreato Bilier Cerrahi Derneği, Türk Hastane Enfeksiyonları ve Kontrolü Derneği üyelerinden konuya ilgi duyan toplam 15 uzman tarafından yapılan toplantılarda çalışmalar değerlendirildi. Sonuçta, erişkinler için hazırlanan bu uzlaşı raporundaki öneriler, ağırlıklı olarak Amerika Enfeksiyon Hastalıkları ve Cerrahi Enfeksiyon Derneği tarafından hazırlanan erişkin ve çocuklarda komplike İAE'lerin tanısı ve yönetimi 2010 rehberi olmak üzere, ulaşılabilen rehberlerden yararlanılarak ülkemiz verileriyle hazırlandı. Öneriler; hasta ile ilk karşılaşmadan başlayarak tanısal değerlendirme ve tedavi yaklaşımı olmak üzere iki bölümde oluşturuldu. Hazırlanan uzlaşı raporu ilk kez Antalya'da Türkiye EKMUD 2016 Kongresi'nde sunuldu. Takiben bir ay süre ile derneklerin sitelerinde önerilere açıldı. Öneriler alındıktan sonra gözden geçirilerek son hali makale olarak yazıldı.

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The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis

Cited by 65 publications

References 25 publications

Systemic and Flap Inflammatory Response Associates with Thrombosis in Flap Venous Crisis

Systemic and Flap Inflammatory Response Associates with Thrombosis in Flap Venous Crisis

The Efficacy of Abdominal Ultrasonographic Examination in Preventing Negative Appendectomies

Recommendations for Intra-abdominal Infections “Consensus Report”

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