Can CT-Based Arterial and Venous Morphological Markers of Chronic Obstructive Pulmonary Disease Explain Pulmonary Vascular Remodeling?

Li, Rui; Song, Minho; Wang, Ronghua; Su, Ningling; Linning, E

doi:10.1016/j.acra.2023.04.026

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Pulmonary Vascular Remodeling In Chronic Lung Diseases1

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2024

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Cited by 2 publications

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“…Hypoxia exposure additionally damages ECs, and leads to vasoconstriction and consequently compensatory remodeling ( 120 , 121 ). It has also been postulated that progressive capillary loss leads to the simultaneous loss of terminal bronchioles and associated arteries ( 122 – 124 ).…”

Section: Pulmonary Vascular Remodeling In Chronic Lung Diseasesmentioning

confidence: 99%

The vascular perspective on acute and chronic lung disease

Borek,

Birnhuber,

Voelkel

et al. 2023

Journal of Clinical Investigation

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Section: Pulmonary Vascular Remodeling In Chronic Lung Diseasesmentioning

confidence: 99%

The vascular perspective on acute and chronic lung disease

Borek,

Birnhuber,

Voelkel

et al. 2023

Journal of Clinical Investigation

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Expiratory Venous Volume and Arterial Tortuosity are Associated with Disease Severity and Mortality Risk in Patients with COPD: Results from COSYCONET

Stoleriu,

Pienn,

Joerres

et al. 2024

COPD

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The aim of this study was to evaluate the association between computed tomography (CT) quantitative pulmonary vessel morphology and lung function, disease severity, and mortality risk in patients with chronic obstructive pulmonary disease (COPD). Patients and Methods: Participants of the prospective nationwide COSYCONET cohort study with paired inspiratory-expiratory CT were included. Fully automatic software, developed in-house, segmented arterial and venous pulmonary vessels and quantified volume and tortuosity on inspiratory and expiratory scans. The association between vessel volume normalised to lung volume and tortuosity versus lung function (forced expiratory volume in 1 sec [FEV 1 ]), air trapping (residual volume to total lung capacity ratio [RV/TLC]), transfer factor for carbon monoxide (TLCO), disease severity in terms of Global Initiative for Chronic Obstructive Lung Disease (GOLD) group D, and mortality were analysed by linear, logistic or Cox proportional hazard regression. Results: Complete data were available from 138 patients (39% female, mean age 65 years). FEV 1 , RV/TLC and TLCO, all as % predicted, were significantly (p < 0.05 each) associated with expiratory vessel characteristics, predominantly venous volume and arterial tortuosity. Associations with inspiratory vessel characteristics were absent or negligible. The patterns were similar for relationships between GOLD D and mortality with vessel characteristics. Expiratory venous volume was an independent predictor of mortality, in addition to FEV 1 .

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Can CT-Based Arterial and Venous Morphological Markers of Chronic Obstructive Pulmonary Disease Explain Pulmonary Vascular Remodeling?

Cited by 2 publications

References 31 publications

The vascular perspective on acute and chronic lung disease

The vascular perspective on acute and chronic lung disease

Expiratory Venous Volume and Arterial Tortuosity are Associated with Disease Severity and Mortality Risk in Patients with COPD: Results from COSYCONET

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