Can complete blood count parameters that change according to trimester in pregnancy be used to predict severe preeclampsia?

Bülbül, Mehmet; Üçkardeş, Fatih; Karaçor, Talip; Nacar, Mehmet Can; Kaplan, Selçuk; Kirici, Pınar; Surucu, Adem

doi:10.1080/01443615.2020.1854697

Cited by 10 publications

(4 citation statements)

References 38 publications

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“…This finding aligns with two separate studies that reported no significant variance (p=0.337; p=0.678) in RBC levels between cases of PE with and without severe features [22,23]. Research on RBC is quite limited, in contrast to RDW, which has been extensively investigated and has great promise as a marker for PE, whether severe features are present [22,24,25].…”

Section: Discussionsupporting

confidence: 89%

Predictive biomarkers of preeclampsia severity in a low resource setting: Role of red blood cell indices, NLR, and albumin-to-creatinine ratio

Tobing,

Lumbanraja,

Lintang

et al. 2024

Narra J

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Preeclampsia (PE), a serious medical condition with substantial maternal and perinatal implications, poses a significant challenge, particularly in high-incidence countries like Indonesia. Red blood cell (RBC) indices, neutrophil-to-lymphocyte ratio (NLR), and microalbuminuria (albumin-to-creatinine ratio (ACR)) may signal systemic inflammation and endothelial dysfunction, recently recognized as potential indicators for diagnosing and predicting disease severity. The aim of this study was to analyze RBC indices, NLR, and ACR changes in women with PE and their potential for predicting disease severity. A cross-sectional study was conducted at multi-center hospitals across Medan, Indonesia, from June 2022 to June 2023. The patients were grouped into PE cases with and without severe features. Demographic characteristics and complications were recorded while blood and urine were tested. The Chi-squared test, Fisher's exact test and Mann-Whitney test were used to determine biomarkers associated with severe PE. A total of 208 PE patients were included in the study (104 patients for each PE with and without severe features). Our data indicated that PE patients with severe features had higher red cell distribution width (18.5% vs 13.7%; p<0.001), NLR (5.66% vs 4.1%; p<0.001), and ACR (755.97 mg/dL vs 468.63 mg/dL; p<0.001) compared to those without severe features. In contrast, the platelet count was lower in severe features than those without (21.9 × 106/µL vs 27.0 × 106/µL; p=0.002). This study highlighted that PE patients with severe features predominantly had higher levels of RDW, NLR, and ACR and lower platelet counts compared to those without severe features. Therefore, basic tests such as complete blood count and urinalysis, which are inexpensive and feasible in primary care settings with limited resources, offer hope as valuable diagnostic biomarkers for pregnant women diagnosed with PE in a low resource setting.

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Section: Discussionsupporting

confidence: 89%

Predictive biomarkers of preeclampsia severity in a low resource setting: Role of red blood cell indices, NLR, and albumin-to-creatinine ratio

Tobing,

Lumbanraja,

Lintang

et al. 2024

Narra J

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“…The PRISMA flow diagram was conducted regarding strictly The PRISMA 2020 statement: an updated guideline for reporting systematic reviews ( 34 ) ( Figure 1 ). Of the remaining 6 ( 48 – 53 ) pieces of research the data (the NLR values in the control and preeclampsia groups and their standard deviations) got extracted for the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis on first-trimester blood count parameters—is the neutrophil-to-lymphocyte ratio a potentially novel method for first-trimester preeclampsia screening?

Mészáros,

Veres,

Nagyistók

et al. 2024

Front. Med.

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ObjectiveMeta-analysis focusing on the role of first-trimester neutrophil-to-lymphocyte ratio (NLR) in the prediction of preeclampsia.Data sourcesPubMed, Scopus, Web of Science, Cochrane Library, and Embase databases were queried from inception up to December 31, 2022.Study eligibility criteriaThe study included all types of original research that was conducted in humans and values of NLR were measured during the first trimester, among patients who later developed preeclampsia, compared to the values of control groups.Study appraisal and synthesis methodsTwo reviewers independently performed data abstraction and quality appraisal, and disagreements were resolved by consensus and, if necessary, by the opinion of a third reviewer. During the analysis, PRISMA and MOOSE guidelines were followed. All statistical analyses were made with R.ResultsFor the research on the predictive role of NLR values in the first trimester for preeclampsia, a total of 6 studies were selected for analysis, covering 2,469 patients. The meta-analysis revealed a 95% confidence interval (CI) for the effect size of 0.641 to 1.523, with a prediction interval of 0.027 to 2.137.ConclusionBased on the analysis, NLR is a promising biochemical marker for future pieces of research that try to find new screening methods for first-trimester preeclampsia. We encourage other researchers to examine NLR’s predictive value combined with other markers in preeclampsia screening, this way being able to find new and affordable protocols for first-trimester preeclampsia screening.Systematic review registrationidentifier CRD42023392663.

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“…In this case, it may cause long-term chronic hypoxia in the fetus, leading to neonatal respiratory disorders. As a second mechanism, it may cause pulmonary hypertension by causing neonatal pulmonary vasculature and systemic vascular dysfunction 21,22 . We found that Apgar scores were significantly lower at the 1 st and 5 th min in the preeclampsia group than in the control group.…”

Section: Discussionmentioning

confidence: 99%

¿Pueden los marcadores de activación plaquetaria predecir la preeclampsia y/o su gravedad?

ArslanoÓlu,

Kurt-Bilirer,

ÓallıoÓlu

et al. 2024

CIRU

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Objective: This study aimed to evaluate the value of platelet activation markers in predicting preeclampsia and its severity. Preeclampsia is a serious pregnancy complication that affects 3-5% of pregnancies and can lead to significant morbidity and mortality for both the mother and the fetus. Methods: The study included 99 patients diagnosed with preeclampsia and 60 healthy pregnant women as a control group. Platelet activation markers such as mean platelet volume (MPV), platelet distribution width (PDW), platelet count, and plateletcrit were evaluated along with other clinical parameters. Results: The results of the study showed that platelet activation markers, particularly PDW and MPV, are valuable in the diagnosis and follow-up of preeclampsia. However, they are not sufficient to predict the severity of the disease. Conclusion: The study suggests that platelet activation markers could aid in predicting, diagnosing, and managing preeclampsia. However, further research is needed to determine the role of these markers in predicting the severity of the disease. The findings of this study could contribute to the development of more effective strategies for the prevention and management of preeclampsia, which could ultimately improve maternal and fetal outcomes.

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Can complete blood count parameters that change according to trimester in pregnancy be used to predict severe preeclampsia?

Cited by 10 publications

References 38 publications

Predictive biomarkers of preeclampsia severity in a low resource setting: Role of red blood cell indices, NLR, and albumin-to-creatinine ratio

Predictive biomarkers of preeclampsia severity in a low resource setting: Role of red blood cell indices, NLR, and albumin-to-creatinine ratio

A meta-analysis on first-trimester blood count parameters—is the neutrophil-to-lymphocyte ratio a potentially novel method for first-trimester preeclampsia screening?

¿Pueden los marcadores de activación plaquetaria predecir la preeclampsia y/o su gravedad?

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