Can bone-regulating hormones and nutrients help characterize the metabolically healthy obese phenotype

Sukumar, Deeptha; Becker, Kendra; Cheung, May; Diamond, Samantha; Duszak, Rittane; Aljahdali, Abeer; Volpe, Stella L.; Nasser, Jennifer A.

doi:10.1177/0260106018777336

Cited by 7 publications

(9 citation statements)

References 68 publications

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“…Therefore, they concluded that diet composition does not explain the absence of cardiometabolic abnormalities in obese adults. However, Sukumar et al 19 stated that dietary magnesium intake might help to characterize the MHO phenotype, which is in agreement with our results.…”

Section: Discussionsupporting

confidence: 93%

“…Inconsistencies between the study by Hankinson et al 18 and the results from Sukumar et al 19 and our study could be related to the definition of the MHO phenotype.…”

Section: Discussioncontrasting

confidence: 49%

“…Studies analyzing the role that dietary magnesium intake may play in the cardiometabolic profile of obese individuals are scarce and inconsistent. 18 19 Hankinson et al 18 reported that magnesium intake had non-significant differences between adults with the MHO phenotype and MUO. Therefore, they concluded that diet composition does not explain the absence of cardiometabolic abnormalities in obese adults.…”

Section: Discussionmentioning

confidence: 99%

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Magnesium intake is associated with the metabolically healthy obese phenotype

Guerrero‐Romero

Morales-Gurrola

Preza‐Rodríguez

et al. 2022

Journal of Investigative Medicine

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Although magnesium intake is inversely associated with the risk of metabolic abnormalities, whether magnesium intake plays a role on metabolically healthy obese (MHO) phenotype has not been explored. Therefore, the purpose of this study was to determine whether the magnesium intake is associated with the MHO phenotype. Apparently, healthy women and men aged 20–65 years with obesity were enrolled in a cross-sectional study. Subjects were allocated into MHO (n=124) and metabolically unhealthy obese (MUO) (n=123) groups. MHO phenotype was defined by abdominal obesity (waist circumference ≥90 cm in men and ≥80 cm in women) and none, or not more than one of the following risk factors: triglyceride levels ≥150 mg/dL; high-density lipoprotein cholesterol (HDL-C) levels <40 mg/dL in men and <50 mg/dL in women; fasting glucose ≥100 mg/dL; and systolic blood pressure ≥130 mm Hg and/or diastolic blood pressure ≥85 mm Hg. The MUO individuals were characterized by abdominal obesity and the presence of two or more of the aforementioned criteria. The proportion of individuals with high blood pressure (40.7% vs 5.6%, p<0.001), hyperglycemia (69.1% vs 16.9%, p<0.001), hypertriglyceridemia (84.6% vs 36.3%, p<0.001), and low HDL-C (51.2% vs 12.9%, p<0.001) was significantly higher in the MUO individuals as compared with individuals in the MHO group. The logistic regression analysis adjusted by sex and age showed that dietary magnesium intake is significantly associated with the MHO phenotype (OR=1.17; 95% CI 1.07 to 1.25, p=0.005). Our results show that magnesium intake is significantly associated with the MHO phenotype.

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Section: Discussionsupporting

confidence: 93%

“…Inconsistencies between the study by Hankinson et al 18 and the results from Sukumar et al 19 and our study could be related to the definition of the MHO phenotype.…”

Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Magnesium intake is associated with the metabolically healthy obese phenotype

Guerrero‐Romero

Morales-Gurrola

Preza‐Rodríguez

et al. 2022

Journal of Investigative Medicine

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“…Furthermore, our findings may be explained through the bone-regulating role of hormones and nutrients. A novel study showed that MHO adults had higher serum concentrations of ionized magnesium, dietary magnesium intakes, and serum osteocalcin while lower serum PTH compared to MUO adults (38). Magnesium, together with the thyroid and parathyroid glands support bone health by stimulating the production of calcitonin, known to act as a bonepreserving hormone and regulating PTH (39).…”

Section: Discussionmentioning

confidence: 99%

Differences in areal bone mineral density between metabolically healthy and unhealthy overweight/obese children: the role of physical activity and cardiorespiratory fitness

et al. 2019

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Objectives: 1) to examine whether areal bone mineral density (aBMD) differs between metabolically healthy (MHO) and unhealthy (MUO) overweight/obese children, and 2) to examine the role of moderate-to-vigorous physical activity (MVPA), and cardiorespiratory fitness (CRF) in this association. Methods: a cross-sectional study was developed in 188 overweight/obese children (10.4 ± 1.2y) from the ActiveBrains and EFIGRO studies. Participants were classified as MHO or MUO based on Jolliffe and Janssen´s metabolic syndrome cutoff points for triglycerides, glucose, high-density cholesterol, and blood pressure. MVPA and CRF were assessed by accelerometry and the 20-meters shuttle run test, respectively. Body composition was measured by Dual-energy X-ray absorptiometry. Results: in model 1 (adjusted for sex, years from peak high velocity, stature and lean mass), MHO children had significantly higher aBMD in total body less head (Cohen´s d effect size, ES=0.34), trunk (ES=0.43) and pelvis (ES=0.33), than MUO children. These differences were attenuated once MVPA was added to the model 1 (model 2), and most of them disappeared once CRF was added to the model 1 (model 3). Conclusions: This novel research shows that MHO children have greater aBMD than their MUO peers. Furthermore, both MVPA and more importantly CRF, seem to partially explain these findings.

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“…Teniendo en cuenta los niveles séricos de Mg encontrados en nuestro estudio, el 96% de los hombres los tenían dentro del rango normal, lo que dificulta cualquier interpretación de nuestros hallazgos. Las interrelaciones complejas no se pueden interpretar directamente, sin embargo, una investigación reciente presentó, como un intento, lo que llamaron sujetos "obesos metabólicamente saludables/no saludables", que incluían PTH sérica, Mg, VD y otros parámetros, para hacer la distinción (36) .…”

Section: Discussionunclassified

Vitamina D, magnesio y parámetros seleccionados de laboratorio en hombres uruguayos

Mendoza

Cabrera

Mintegui

et al. 2021

RMU

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Introducción: los niveles de vitamina D (VD) plasmática se han investigado sobre todo en mujeres, no obstante también son relevantes en hombres, y no sólo en relación al estado de salud ósea. Un estudio previo realizado hace dos décadas en una pequeña muestra de hombres y mujeres uruguayos reveló serias deficiencias de VD. Por otra parte, el magnesio posee importantes efectos no solo relacionados a los niveles de VD, también afecta el hueso directa e indirectamente.Objetivos: analizar posibles interrelaciones entre valores de VD plasmática, testosterona plasmática, densitometría ósea, y otros parámetros en una población de jóvenes varones uruguayos.Métodos: durante julio-agosto de 2015, cien hombres uruguayos afiliados al sistema prepago de salud fueron invitados a participar en nuestra Unidad de Metabolismo Fosfocálcico, para ser estudiados con técnicas de antropometría, laboratorio y densitométricas. Los datos colectados fueron analizados estadísticamente.Resultados: los hombres estudiados mostraron bajos niveles de VD plasmática (96% insuficientes-deficientes), que no mostraron correlaciones significativas con ninguno de los parámetros estudiados. El magnesio plasmático se correlacionó significativa e inversamente con los z-scores densitométricos, lo que fue más intenso en hombres con sobrepeso y con VD ≥15 ng/ml.Conclusiones: a pesar de lo pequeño de la muestra, los resultados confirman la presencia de bajos niveles de VD en hombres aparentemente saludables. Los hallazgos dan razones para pensar en posibles recomendaciones para mejorar el espectro preventivo enfocado en osteoporosis y cáncer colorrectal.

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Can bone-regulating hormones and nutrients help characterize the metabolically healthy obese phenotype

Abstract: These findings suggest that bone-regulating hormones and nutrients, especially serum PTH, osteocalcin concentrations, and dietary Mg intakes, can help to characterize the MHO phenotype.

Cited by 7 publications

References 68 publications

Magnesium intake is associated with the metabolically healthy obese phenotype

Magnesium intake is associated with the metabolically healthy obese phenotype

Differences in areal bone mineral density between metabolically healthy and unhealthy overweight/obese children: the role of physical activity and cardiorespiratory fitness

Vitamina D, magnesio y parámetros seleccionados de laboratorio en hombres uruguayos

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