Can biofeedback-based training alleviate fatigue and vigilance performance in fatigued MS patients?

Sander, C; Braun, Niclas; Modes, Fenja; Schlake, Hans-Peter; Eling, Paul; Hildebrandt, Helmut

doi:10.1080/09602011.2020.1808023

Cited by 5 publications

(7 citation statements)

References 41 publications

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“…Fatigue is a comprehensive response to many physiological and biochemical changes in the body caused by multiple factors [ 1 ]. In 1982, the Fifth International Conference on exercise biochemistry defined it as follows: the physiological process of the body cannot maintain its function at a specific level or each organ cannot maintain its predetermined exercise intensity [ 2 ]. Fatigue is divided into physical fatigue and psychological fatigue.…”

Section: Introductionmentioning

confidence: 99%

Image Effect Observation of Acanthopanax senticosus on Antifatigue Activity after Exercise

Zhang

Zhu

2022

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In order to explore the effect of Acanthopanax senticosus on antifatigue activity after exercise, this paper proposes an image effect observation based on the effect of Acanthopanax senticosus on antifatigue activity after exercise. This method recommends key technical problems and solutions based on the information represented by image effect observation and explores the influence of Acanthopanax senticosus on antifatigue after exercise. Through the retrospective analysis of certain personnel, it is shown that the image effect observation based on the influence of Acanthopanax senticosus on the antifatigue activity after exercise is about 25% more accurate than the traditional method. Most of the active ingredients of Acanthopanax senticosus have phenolic hydroxyl groups, which can resist oxidation, fatigue, focus attention, and reduce work mistakes. This experiment shows that after sleep deprivation, the antioxidant capacity of the body decreases with time. Acanthopanax senticosus extract can significantly improve the above symptoms and fight fatigue.

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Section: Introductionmentioning

confidence: 99%

Image Effect Observation of Acanthopanax senticosus on Antifatigue Activity after Exercise

Zhang

Zhu

2022

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“…Targeted changes in ANS activity are also known to occur in response to deep breathing and relaxation [65]. That is, deep breathing techniques increase vagal nerve activity, signaling the PANS to calm the body down [66] due to an entrainment between respiratory rate and vagal tone [67].…”

Section: Hrv Adaptation In Rest and During Orthostatic Challengementioning

confidence: 99%

“…Sander et al [65] treated 50 persons with MS-related fatigue with a single trial containing two different kinds of a biofeedback intervention. They looked for the impact of the two biofeedback exercises on fatigue before and after performing a vigilance task.…”

Section: What Is Known About Hrv and Fatigue In Msmentioning

confidence: 99%

“…The MS patients were divided by those suffering from severe fatigue (defined by the total score of the FSMC) or from weak to moderate fatigue. Sander et al [65] focused their HRV analysis on SDNN and pNN50. They found that the group with high fatigue showed significantly lower SDNN and pNN50 scores than the group with weak to moderate fatigue.…”

Section: What Is Known About Hrv and Fatigue In Msmentioning

confidence: 99%

“…We found that, irrespective of disease duration and disease course, MS patients demonstrate a lower PANS-related HRV during rest and during deep breathing ("HRV adaptation in rest and during orthostatic challenge" section). Studies directly measuring the relationship between HRV and fatigue also demonstrated that MS patients with fatigue have a lower PANS-related HRV and that the LF/HF ratio correlated with fatigue ("What is known about HRV and fatigue in MS" section) [65,81,87]. A study by Sander et al [65] compared MS groups with differing fatigue status on HRV parameters and implemented an experimental intervention (biofeedback).…”

Section: Hrv and Fatigue In Ms: A Common Pathway Of Disseminated Infl...mentioning

confidence: 99%

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Heart rate variability and fatigue in MS: two parallel pathways representing disseminated inflammatory processes?

et al. 2022

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Background Fatigue is a disabling symptom of multiple sclerosis. Its biological causes are still poorly understood. Several years ago, we proposed that fatigue might be the subjective representation of inflammatory processes. An important step for a straight-forward evaluation of our model would be to show that the level of fatigue is associated with vagal activation. The heart rate is under partial control of the vagus nerve. Using power spectrum analysis allows to separate, at least partly, sympathetic and parasympathetic impact on heart rate variability. Methods This narrative review summarizes the evidence for heart rate variability changes in MS patients, their relationship with fatigue and disease course. To do this, we conducted a literature search, including 45 articles relevant to the topic treated in this review. Results We illustrate that (1) inflammation leads to a change in cardiac behavior during acute and chronic phases, both in animals and in humans; (2) MS patients show changes of heart rate variability (HRV) that resemble those during acute and chronic inflammation due to multiple causes; (3) existing evidence favors a set of specific predictions about fatigue and parallel HRV changes; and (4) that MS-related brainstem lesions or neurological impairments do not completely explain HRV changes, leaving enough place for an explanatory relation between HRV and fatigue. Discussion We discuss the results of this review in relation to our model of fatigue and propose several observational and experimental studies that could be conducted to gain a better insight into whether fatigue and HRV can be interpreted as a common pathway, both reflecting activated autoimmune processes in MS patients.

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Comparing two relaxation procedures to ease fatigue in multiple sclerosis: a single-blind randomized controlled trial

Garis,

Dettmers,

Hildebrandt

et al. 2023

Neurol Sci

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Background Various relaxation procedures have been proposed to reduce fatigue in multiple sclerosis (MS). However, it is unknown, which type of relaxation has the largest effect on fatigue reduction and on autonomic nervous system (ANS) activity. Objective We aimed to compare two biofeedback-supported relaxation exercises: a deep breathing (DB) exercise and progressive muscle relaxation (PMR), which may ameliorate MS fatigue and alter ANS activity. Methods We performed a single-blind randomized clinical trial, introducing MS patients (n = 34) to the DB or PMR exercise. We first tested cardiovagal integrity, reflected by changes in heart rate variability (HRV) in response to DB. Participants then performed a fatigue-inducing vigilance task, followed by the DB or PMR. State fatigue was recorded consecutively at baseline, after the vigilance task, and after the relaxation exercise, along with HRV reflecting ANS activity. Results Only patients assigned to the PMR group experienced a significant drop in fatigue, whereas both relaxation exercises changed ANS activity. MS patients showed the expected autonomic response during the cardiovagal reflex test. The vigilance task elevated short-term feelings of fatigue and significantly reduced HRV parameters of parasympathetic activity. Trait fatigue was negatively correlated with HRV during the second half of the vigilance task. Conclusion PMR alleviates short-term feelings of fatigue in persons with MS. The vigilance task in combination with HRV measurements may be helpful for evaluating relaxation procedures as a treatment of fatigue. Hereby, future studies should ensure longer and more frequent relaxation exercises and focus on patients with weak to moderate fatigue. Trial registration Trial Registry: DRKS00024358.

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Can biofeedback-based training alleviate fatigue and vigilance performance in fatigued MS patients?

Cited by 5 publications

References 41 publications

Image Effect Observation of Acanthopanax senticosus on Antifatigue Activity after Exercise

Image Effect Observation of Acanthopanax senticosus on Antifatigue Activity after Exercise

Heart rate variability and fatigue in MS: two parallel pathways representing disseminated inflammatory processes?

Comparing two relaxation procedures to ease fatigue in multiple sclerosis: a single-blind randomized controlled trial

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