thought to have jumped species from another mammal to humans. This virus has caused a rapidly spreading global pandemic. To date, thousands of cases of COVID-19 have been reported in England, and over 18,000 patients have died. While there has been progress in managing this disease, it is not clear which factors, in addition to age, affect the severity and mortality of COVID-19. A recent analysis of COVID-19 in Italy identified links between air pollution and death rates. Here, we explored potential links between three major air pollutants related to fossil fuels and SARS-CoV-2 mortality in England. We compared current, SARS-CoV-2 cases and deaths recorded in public databases to region-level air pollution data monitored at over 120 sites across England. We found that the levels of some markers of poor air quality, nitrogen oxides and ozone, were associated with COVID-19 mortality in different English regions, after adjusting for population density. We conclude that the levels of some air pollutants are linked to COVID-19 cases and morbidity. We consider that our study provides a useful framework to guide health policies in countries affected by this pandemic.