Can acetic acid substitute ethanol for the reduction of cardiovascular disease risks?

Abstract

Acetic acid and ethanol are structurally similar to oxalate. Oxalate is produced from the shunt of Krebs cycle and other metabolic pathways. Both acetic acid and ethanol can reduce the risks of heart diseases 1-4 and extend lifespan, 5,6 perhaps by blocking the generation of oxalate. 7 However, excessive intake of ethanol is associated with moderate cancer risks, 7 which is likely to be associated with its hydrogen bonding capacity that enhances local strong acid formation and subsequent mutagenesis. 7 Observations in China-based vinegar factories have demonstrated that few cancer cases appeared over several decades, suggesting that the weak acid can counteract strong acids such as locally formed hydrochloric acid and reduce mutagenesis and carcinogenesis. 8 This property is superior to ethanol as acetic acid can reduce risks for either cardiovascular disease or cancer. The Krebs cycle is capable of generating both protons and short chain organic acids, and organic acids could antagonise strong acids. 9 When the protons are in excess, cancer may occur. When organic acids are over-produced, age-related diseases then appear. 9 Whether vinegar or acetic acid can substitute ethanol or wines in the prevention of heart diseases warrants further investigation.

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