“…Desirable features of NGCs include biocompatibility with the surrounding tissue, flexibility, the ability to be sutured into the injury site, and the incorporation of chemotactic, structural, and topographical cues for directional axonal regeneration [3,4]. Tissue derived NGCs have included autologous transplants of skeletal muscle, with its basal lamina and anisotropy, tendon, and vein [5], or rinsed small intestinal segments [6], with each displaying variable abilities to repair peripheral nerve lesions. Decellularised nerve allografts have shown promise in bridging small gap injuries [1,2] and, whilst they contain tissue specific ECM, they lack the necessary cellular support required for regeneration across long gaps [2,7].…”