Can a Novel High-Density EEG Approach Disentangle the Differences of Visual Event Related Potential (N170), Elicited by Negative Facial Stimuli, in People with Subjective Cognitive Impairment?

Abstract

These preliminary findings suggest that the amplitude of N170 elicited after negative facial stimuli could be modulated by the decline related to pathological cognitive aging and can contribute in distinguishing HC from SCI, MCI, and AD.

Is brain connectome research the future frontier for subjective cognitive decline? A systematic review

“…In addition to neuropsychological differences among SCD and other patient groups, several studies have found volumetric differences between SCD and healthy elders (van der Flier et al 2004;Striepens et al 2011;Hays et al 2018b) while the structural changes observed in SCD exhibit similarities with the later stages of the AD continuum, showing the potential link of this preclinical stage to cognitive decline due to AD. Additionally, in our previous electrophysiological cross-sectional study (Lazarou et al 2018), we have observed also significant differences between SCD and healthy elders with regards to brain activation, while the SCD showed several commonalities with MCI with respect to reduced activated brain regions after the presentation of visual ERPs.…”

“…), b) the adopted source-localization algorithm for electro and magneto-encephalography (e.g. sLORETA (Lazarou et al, 2018) and LCMV (Dimitriadis et al 2018b(Dimitriadis et al , 2018c etc. ), c) the selection of anatomical Templates (e.g.…”

“…Although SCD might be considered as a prior stage of MCI, until now it is unclear which of the SCD elders will probably convert to MCI and subsequently AD (Mitchell et al 2014;Moreno-Grau and Ruiz 2016). Nevertheless, people with SCD have been found to exhibit neurodegenerative changes in their brain (Elfgren et al 2003;Babiloni et al 2010;Li et al 2016;Hays et al 2018a;Lazarou et al 2018;Li et al 2018a) in similar regional patterns with people in more advanced stages of the AD continuum (van der Flier et al 2004;Rodda et al 2011;López-Sanz et al 2017aShu et al 2017). Several studies have examined the volumetric differences and brain activity among SCD people (Jessen et al 2006;Babiloni et al 2010;van Rooden et al 2014;Hayes et al 2017), while others have investigated connectivity and communication between brain regions of people with SCD (Bajo et al 2012;Hafkemeijer et al 2013;Wang et al 2013;López-Sanz et al 2017b;Yan et al 2018) by investigating brain connectome and network properties through graph theoretical approaches (Broyd et al 2009;van den Heuvel and Hulshoff Pol 2010;Mevel et al 2011;Sexton et al 2011;Badhwar et al 2017;Contreras et al 2017;Hayes et al 2017;López-Sanz et al 2017b;Shu et al 2017;Verfaillie et al 2018aVerfaillie et al , 2018b).…”

“…More specifically, there is a growing body of literature suggesting that Subjective Cognitive Decline (SCD) is associated with the presence of brain changes and disorganization of early cognitive decline related to AD (Reisberg and Gauthier 2008;Rodda et al 2011;Lazarou et al 2018;Mazzon et al 2018). Several longitudinal studies have also underlined the important role of this stage as a precursor of future cognitive decline such as dementia (Ferris and Reisberg 1993;Geerlings et al 1999;Jorm et al 2001;St John and Montgomery 2002;Amariglio et al 2018;Bessi et al 2018;Snitz et al 2018).…”

Amplifying the Neural Power Spectrum

“…Many trials are often required to observe stable spatiotemporal patterns across the brain. Human faces produce some of the most reliable ERPs, with the N170 signal producing a negative voltage deflection at 140 -200 ms in the occipito-temporal electrode sites, and positive voltage in fronto-central regions following human face stimulus presentation [22].…”