Campylobacterantimicrobial resistance in Peru: a ten-year observational study

Pollett, Simon; Rocha, Claudio; Zerpa, Rito; Patiño, Lilian; Valencia, Augusto; Camiña, Máximo; Guevara, Jose M.; López, Martha; Chuquiray, Nancy; Salazar–Lindo, Eduardo; Calampa, Carlos; Casapía, Martín; Meza, Rina; Bernal, María Luisa Pérez del Molino; Tilley, Drake H.; Gregory, Michael J.; Maves, Ryan C; Hall, Eric R.; Jones, Franca R.; Arriola, Carmen Sofia; Rosenbaum, Marieke; Pérez, Juan J.; Kasper, Matthew R.

doi:10.1186/1471-2334-12-193

Cited by 60 publications

(72 citation statements)

References 41 publications

(90 reference statements)

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“…As a zoonotic pathogen transmitted through the food-borne route, Campylobacter is subject to selection pressure from macrolide use in both veterinary medicine and human medicine. Although the overall prevalence of macrolideresistant Campylobacter is relatively low, high incidences of macrolide resistance in Campylobacter have been reported in some studies (5)(6)(7)(8)(9). In order to curb the emergence of macrolide resistance, it is necessary for us to understand how Campylobacter develops resistance to this class of antibiotics.…”

mentioning

confidence: 99%

Mutational and Transcriptomic Changes Involved in the Development of Macrolide Resistance in Campylobacter jejuni

Hao

Zhang

Shen

et al. 2013

Antimicrob Agents Chemother

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mentioning

confidence: 99%

Mutational and Transcriptomic Changes Involved in the Development of Macrolide Resistance in Campylobacter jejuni

Hao

Zhang

Shen

et al. 2013

Antimicrob Agents Chemother

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“…This increase emerged after the licensure of fluoroquinolones (sarafloxacin and enrofloxacin) for use in poultry and in general veterinary medicine (Ruiz-Palacios 2007). Several investigations have demonstrated that an increased prevalence of fluoroquinolone resistance among animals and human Campylobacter isolates is temporally related to the use of fluoroquinolones in veterinary medicine (Smith and Fratamico 2010, Engberg et al 2001, Moore et al 2006, Ruiz-Palacios 2007, Pollett et al 2012, Nelson et al 2007, Endtz et al 1991.…”

Section: Campylobacter and Fluoroquinolone Resistancementioning

confidence: 99%

“…An alarming increase in Campylobacter fluoroquinolone resistance has been documented in many countries (Pollett et al 2012). This increase emerged after the licensure of fluoroquinolones (sarafloxacin and enrofloxacin) for use in poultry and in general veterinary medicine (Ruiz-Palacios 2007).…”

Section: Campylobacter and Fluoroquinolone Resistancementioning

confidence: 99%

“…However, in developing countries, where Campylobacter infection is endemic due to poor sanitation, close contact with animals, and environmental sources like water (Fernández 2011), comprehensive surveillance studies on Campylobacter are rare (Zaidi et al 2012). Although, scarce data from developing countries suggest that Campylobacter infections contribute to a considerable human disease burden (Fernández 2011) also associated to increasing isolation rates of antimicrobial resistant strains (Ruiz-Palacios 2007, Pollett et al 2012.…”

Section: Inroductionmentioning

confidence: 99%

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Campylobacter: fluoroquinolone resistance in Latin-American countries

Fernández

Pérez-Pérez

2016

Arch. med. vet.

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ABSTRACT.Campylobacter jejuni and C. coli are zoonotic bacteria recognised as a major cause of human gastroenteritis and frequent cause of bacterial food-borne illness around the world. A great variety of food-producing animals, especially poultry are important reservoir involved in their spread to humans. Campylobacter gastroenteritis is generally a self-limiting disease avoiding antimicrobial prescription but, when antibiotic therapy is indicated, erythromycin and fluoroquinolone are the drugs of choice. However, Campylobacter has become increasingly resistant to fluoroquinolones with high isolation rates among human and animal strains. This review shows and discusses the data generated in Latin America in relation to fluoroquinolone resistance in Campylobacter highlighting that i) fluorquinolone resistant strains are reported with high frequencies in several countries; ii) the available data allows to confirm that human infection by fluoroquinolone-resistant Campylobacter are originated mainly from the food chain animals and environmental sources; iii) Campylobacter isolation, identification and antimicrobial susceptibility testing have been performed with different analytical methods making necessary the harmonisation and standardisation of diagnostic methods and iv) strengthening Campylobacter antimicrobial resistance surveillance programs and capacity building with the association between public health services and the academic world are necessary.Key words: Campylobacter, fluoroquinolone, resistance, Latin-America. RESUMEN.Campylobacter jejuni y C. coli son bacterias zoonóticas reconocidas como causa importante de gastroenteritis en humanos y agente frecuente de infecciones alimentarias en todo el mundo. Una gran variedad de animales productores de alimentos para consumo humano, especialmente aves, son importantes reservorios involucrados en su transmisión al ser humano. La gastroenteritis por Campylobacter es generalmente autolimitada, dispensando la prescripción de antibióticos, pero cuando la terapia antibiótica es necesaria, la eritromicina y las fluoroquinolonas son los antimicrobianos de elección. Sin embargo, Campylobacter a llegado a ser cada vez más resistente a fluoroquinolonas, con altas tasas de aislamiento, tanto en seres humanos como en animales. Esta revisión muestra y discute los datos generados en América Latina con relación a la resistencia a fluoroquinolonas en Campylobacter destacando que i) cepas resistentes a fluoroquinolonas son reportadas con altas frecuencias en diversos países; ii) los datos disponibles permiten confirmar que la infección humana por Campylobacter resistentes a fluoroquinolonas se origina principalmente por fuentes animales y ambientales; iii) el aislamiento, la identificación y las pruebas de susceptibilidad antimicrobiana para Campylobacter han sido realizadas mediante diferentes métodos analíticos haciendo necesarias la armonización y estandarización de los métodos diagnósticos y iv) es necesario fortalecer los programas de vigilancia de la resistencia antimicr...

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“…O período de incubação é normalmente de 2 a 5 dias, podendo se estender por até 2 semanas (Butzler, 2004;Young et al, 2007). Em casos mais graves, onde a reposição hidroeletrolítica não se faz suficiente, o uso de antimicrobianos é recomendado (Snelling et al, 2005;Pollett et al, 2012).…”

Section: Manifestações Clínicas E Patogêneseunclassified

Caracterização molecular de linhagens de Campylobacter coli isoladas de origens diversas

Gomes¹

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Este espaço é dedicado àqueles que, de alguma forma, contribuíram para que esta dissertação fosse realizada. Não sendo viável nomeá-los a todos, há no entanto alguns a quem não posso deixar de manifestar o meu apreço e agradecimento sincero.Á Deus pela benção da vida, proteção e força para superar os obstáculos ao longo da minha jornada.À Profª Drª Juliana Pfrimer Falcão, pela orientação, pelo carinhoso apoio, partilha do saber e as valiosas contribuições para a realização desse trabalho. Acima de tudo, obrigada por continuar a acompanhar-me nesta jornada e por estimular o meu interesse pelo conhecimento. Agradeço pela confiança em mim depositada, pelo empenho, paciência e o exemplo profissional e moral durante todo esse período. Minha profunda admiração. Muito Obrigada por tudo! Á minha querida e amada Mãe pelo amor sem reservas, pelos momentos de carinho e por tornar a minha vida mais colorida. Ao meu Pai pela figura firme e segura que me empurra nos momentos mais difíceis, por tornar possível os meus sonhos e conquistas. Não tenho palavras para descrever esse Amor! Aos meus queridos irmãos Gabriela, Marcos, Carina e ao meu sobrinho João Vitor pelo incentivo, apoio e carinho. Vocês são parte de mim! Á aquele que não leva jeito com as palavras, mas tem um abraço que me acalma, um olhar que me alegra, um sorriso que conforta e um amor que me transforma. Alessandro, "Não me lembro mais qual foi nosso começo. Sei que não começamos pelo começo. Já era amor antes de ser"! strains; the flhA gene was detected in 11 (17.5%) strains; the dnaJ gene was detected in 10 (15.9%) strains; the pldA gene was detected in 7 (11.1%) strains ; the iamA gene was detected in three (4.8%) strains; the cdtC and docA genes were found in two (3.2%) strains; the cdtA and crsA were found in one (1.6%) strain and the ciaB, wlaN, virB11 and racR genes were not detected. Among the 63 strains studied, 42 were susceptible to all antimicrobials tested. Of the 21 resistant strains, 10 (15.9%) were resistante to tetracycline and doxaciclyne, six (9.5%) showed resistance to ciprofloxacin, and one (1.6%) was resistant to erythromycin. Only four (6.3%) strains were simultaneously resistant to at least two different classes of the antibiotics tested. The dendrogram of genetic similarity of Pulsed field gel electrophoresis (PFGE) grouped the 63 strains studied into two groups namely PFGE-A and PFGE-B with a genomic similarity of 44.9% among them. However, some strains isolated from humans, animals, the environment and food presented a high genotypic similarity above 80% and were subdivided into seven groups designated as PFGE-A1 to PFGE-A7. The dendrogram of genetic similarity of the SRV-flaA gene sequences grouped the strains studied into two groups namely SVR-A and SVR-B, with similarity above 83.1% among them. Besides, the deposit of the SVR sequences of the flaA gene in the online database showed that the alleles 30 and 1647 were the iv most frequently found and allowed the comparison between the strains studied with the alleles described in the d...

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Campylobacterantimicrobial resistance in Peru: a ten-year observational study

Cited by 60 publications

References 41 publications

Mutational and Transcriptomic Changes Involved in the Development of Macrolide Resistance in Campylobacter jejuni

Mutational and Transcriptomic Changes Involved in the Development of Macrolide Resistance in Campylobacter jejuni

Campylobacter: fluoroquinolone resistance in Latin-American countries

Caracterização molecular de linhagens de Campylobacter coli isoladas de origens diversas

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