Campylobacter bacteremia in London: A 44-year single-center study

Abstract

Purpose Campylobacter species are a well recognized but rare cause of bloodstream infection. Results Patients had a mean age of 46 years and, contrasting with previous reports, nearly 50% of our patients did not have significant comorbidities. MethodsCiprofloxacin resistance increased over the study period with 35% of isolates overall being resistant compared with only 3% exhibiting macrolide resistance.Despite a minority of patients receiving appropriate empirical antibiotic therapy, overall mortality was only 7%.Conclusion Campylobacter bacteraemia remains a rare but significant cause of morbidity with a low associated mortality. Underlying immunosuppressive conditions are common but by no means universal. In our setting, macrolides would be favoured as empirical agents to treat suspected Campylobacter enteritis, including cases with associated bacteraemia.

Campylobacter fetus bacteremia complicated by multiple splenic abscesses and multivisceral signs in a renal transplant recipient: a case report and review of the literature

“…First, C. fetus septicemia is rare, and may be difficult to diagnose, with, in the report, a prolonged diagnostic delay of more than two months. In fact, there are few retrospective cohorts of patients with Campylobacter bacteremia in the literature, 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 one of the largest being that of Pacanowski et al . (2008).…”

“…infections have only been described eight times in renal transplant patients, with only two cases of C. fetus . 6 , 10 , 11 , 12 , 13 , 14 , 15 The cohort of Pacanowski et al . also included six transplant patients, but of unspecified sites.…”

“…Campylobacter spp . bacteremia mortality ranges from 2 to 28% in retrospective series, 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 with several series reporting a death rate greater than 15%. 2 , 3 , 5 The lack of appropriate antibiotic treatment is found as an independent factor of mortality, 2 although the evolution seems to be favorable for most untreated or inadequately treated patients.…”

“… 2 , 3 , 5 The lack of appropriate antibiotic treatment is found as an independent factor of mortality, 2 although the evolution seems to be favorable for most untreated or inadequately treated patients. 7 , 11 …”

Recurrent Campylobacter Bacteremia as the First Manifestation of Hypogammaglobulinemia: A Case Report and Literature Review

“…The majority of their patients had an underlying form of immunodeficiency, including liver disease, HIV infection, malignancy, solid organ transplantation, and hypogammaglobulinemia. O'Hara et al [6] evaluated 41 episodes of Campylobacter bacteremia in 41 patients treated at their hospital in London, the United Kingdom, between 1972 and 2013, 20 of which were caused by C. jejuni. The focus was the gastrointestinal (GI) tract in 70.7% of the episodes but in other episodes the focus could not be identified.…”