cAMP-dependent protein kinase regulates secretion of apical membrane antigen 1 (AMA1) in Plasmodium yoelii

Ishizaki, Takahiro; Asada, Masahito; Hakimi, Hassan; Chaiyawong, Nattawat; Kegawa, Yuto; Yahata, Kazuhide; Kaneko, O.

doi:10.1016/j.parint.2021.102435

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…Exposure of released merozoites to low blood potassium concentration is followed by their stimulation by increased cytosolic calcium levels that inducs AMA1 secretion from micronemes. A study [108] demonstrated the role of PfPKA in simultaneous AMA1 phosphorylation, an essential molecule in RBCs invasion. The investigators showed several differences between P. falciparum and P. yoelii.…”

Section: [Iv] Other Targets 1 Molecules For Invasion and Egress Cascadementioning

confidence: 99%

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Recent advances in identification of potential drug targets and development of novel drugs in parasitic diseases. Part IV. Plasmodium spp.

Abaza

2022

Parasitologists United Journal

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In the last two decades, transporters attracted much attention in identification of potential drug targets against intracellular protozoa. Several membrane molecules exhibit essential roles in trafficking pathways for nutrients, essential enzymes and virulence factors. In this context, P. falciparum possesses a complex of genomic plasticity-encoding transporters with high potentiality for aneuploidy, and gene expression modulation in response to drug exposure. Therefore, it is able to undergo gene mutations in enzymes controlling drug uptake, and evade host immune response by antigenic variations as well. The genetic mechanism of antimalarial drug resistance arises early with monotherapy using fast-acting drugs or a single targeting drug. Accordingly, combined therapy acting on multiple targets would decrease the emergence of drug resistance. Evolutionary technology on genetic approach enabled researchers to identify and propose novel Plasmodium drug targets. The main objective of this part is to review potential drug targets for apicomplexans and discuss recent approaches in identifying Plasmodium targets, as well as advances in the design and development of novel antimalarial drugs.

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Section: [Iv] Other Targets 1 Molecules For Invasion and Egress Cascadementioning

confidence: 99%

“…Third, RON2 expression was not affected by pka gene deletion in P. yoelii. Accordingly, it was suggested that P. falciparum AMA1-RON2 interaction played the major role in RBC de novo invasion [108] .…”

Section: [Iv] Other Targets 1 Molecules For Invasion and Egress Cascadementioning

confidence: 99%

Recent advances in identification of potential drug targets and development of novel drugs in parasitic diseases. Part IV. Plasmodium spp.

Abaza

2022

Parasitologists United Journal

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Distinct effects on the secretion of MTRAP and AMA1 in Plasmodium yoelii following deletion of acylated pleckstrin homology domain-containing protein

Chaiyawong

Ishizaki

Hakimi

et al. 2022

Parasitology International

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cAMP-dependent protein kinase regulates secretion of apical membrane antigen 1 (AMA1) in Plasmodium yoelii

Cited by 2 publications

References 34 publications

Recent advances in identification of potential drug targets and development of novel drugs in parasitic diseases. Part IV. Plasmodium spp.

Recent advances in identification of potential drug targets and development of novel drugs in parasitic diseases. Part IV. Plasmodium spp.

Distinct effects on the secretion of MTRAP and AMA1 in Plasmodium yoelii following deletion of acylated pleckstrin homology domain-containing protein

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